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AB120661

Minocycline hydrochloride, Antibiotic

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(3 Publications)

MW 493.94 g/mol, Purity >98%. Antibiotic. Demonstrates anti-inflammatory, antiapoptotic, antioxidant and neuroprotective effects. Blood-brain barrier permeable. Matrix metalloproteinase (MMP) inhibitor (IC50 = 290 μM at stromelysin (MMP-3).
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Chemical Structure - Minocycline hydrochloride, Antibiotic (AB120661)
  • Chemical Structure

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Chemical Structure - Minocycline hydrochloride, Antibiotic (AB120661)

2D chemical structure image of ab120661, Minocycline hydrochloride, Antibiotic

Key facts

CAS number

13614-98-7

Purity

>98%

Form

Solid

form

Molecular weight

493.94 g/mol

Molecular formula

C<sub>2</sub><sub>3</sub>H<sub>2</sub><sub>7</sub>N<sub>3</sub>O<sub>7</sub>.HCl

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM (with warming)

Soluble in water to 25 mM (with warming)

Biological description

Antibiotic. Demonstrates anti-inflammatory, antiapoptotic, antioxidant and neuroprotective effects. Blood-brain barrier permeable. Matrix metalloproteinase (MMP) inhibitor (IC50 = 290 μM at stromelysin (MMP-3).

IUPAC Name

[4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide hydrochloride

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Product protocols

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Brain sciences 13: PubMed37239211

2023

Glabridin Therapy Reduces Chronic Allodynia, Spinal Microgliosis, and Dendritic Spine Generation by Inhibiting Fractalkine-CX3CR1 Signaling in a Mouse Model of Tibial Fractures.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Long,Hongbing Liu,Zhimin Qiu,Zhong Xiao,Zhongqiu Lu

Cell reports 22:693-705 PubMed29346767

2018

Functional Principles of Posterior Septal Inputs to the Medial Habenula.

Applications

Unspecified application

Species

Unspecified reactive species

Yo Otsu,Salvatore Lecca,Katarzyna Pietrajtis,Charly Vincent Rousseau,Païkan Marcaggi,Guillaume Pierre Dugué,Caroline Mailhes-Hamon,Manuel Mameli,Marco Alberto Diana

Frontiers in pharmacology 7:367 PubMed27761113

2016

Ester Hydrolysis Differentially Reduces Aconitine-Induced Anti-hypersensitivity and Acute Neurotoxicity: Involvement of Spinal Microglial Dynorphin Expression and Implications for Processing.

Applications

Unspecified application

Species

Unspecified reactive species

Teng-Fei Li,Nian Gong,Yong-Xiang Wang
View all publications

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