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MW 432.5 Da, Purity >98%. Allosteric, selective, non-ATP competitive pan-Akt inhibitor (IC50 = 5.0, 4.5, and 16 nM for Akt1, Akt2, and Akt3, respectively). Selective for Akt isoforms over a panel of 303 other kinases. Binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. Orally bioavailable.
- CAS number
1313881-70-7
- Purity
> 98%
- Form
Solid
- Molecular weight
432.5 Da
- Molecular formula
C27H24N6
- PubChem identifier
53262401
- Nature
Synthetic
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MW 432.5 Da, Purity >98%. Allosteric, selective, non-ATP competitive pan-Akt inhibitor (IC50 = 5.0, 4.5, and 16 nM for Akt1, Akt2, and Akt3, respectively). Selective for Akt isoforms over a panel of 303 other kinases. Binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. Orally bioavailable.
Key facts
- CAS number
1313881-70-7
- Purity
> 98%
- Form
Solid
- Molecular weight
432.5 Da
- Molecular formula
C27H24N6
- PubChem identifier
53262401
- Nature
Synthetic
- Biochemical name
Miransertib
- Biological description
Allosteric, selective, non-ATP competitive pan-Akt inhibitor (IC50 = 5.0, 4.5, and 16 nM for Akt1, Akt2, and Akt3, respectively). Selective for Akt isoforms over a panel of 303 other kinases. Binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. Orally bioavailable.
- Canonical SMILES
C1CC(C1)(C2=CC=C(C=C2)N3C4=C(C=CC(=N4)C5=CC=CC=C5)N=C3C6=C(N=CC=C6)N)N
- InChI
InChI=1S/C27H24N6/c28-24-21(8-4-17-30-24)25-32-23-14-13-22(18-6-2-1-3-7-18)31-26(23)33(25)20-11-9-19(10-12-20)27(29)15-5-16-27/h1-4,6-14,17H,5,15-16,29H2,(H2,28,30)
- InChIKey
HNFMVVHMKGFCMB-UHFFFAOYSA-N
- IUPAC name
3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenylimidazo[4,5-b]pyridin-2-yl]pyridin-2-amine
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store in the dark, Store under desiccating conditions
Notes
This product is manufactured by BioVision, an Abcam company and was previously called B1931 Miransertib. B1931-25 is the same size as the 25 mg size of ab235550.
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