Miransertib, pan-Akt inhibitor

Key facts

CAS number

1313881-70-7

Purity

>98%

Form

Solid

form

Molecular weight

432.5 Da

Molecular formula

C₂₇H₂₄N₆

PubChem

53262401

Nature

Synthetic

Solubility

Soluble in DMSO to 159.92 mM

Soluble in ethanol to 8.52 mM

Biochemical name

Miransertib

Biological description

Allosteric, selective, non-ATP competitive pan-Akt inhibitor (IC₅₀ = 5.0, 4.5, and 16 nM for Akt1, Akt2, and Akt3, respectively). Selective for Akt isoforms over a panel of 303 other kinases. Binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. Orally bioavailable.

Canonical smiles

C1CC(C1)(C2=CC=C(C=C2)N3C4=C(C=CC(=N4)C5=CC=CC=C5)N=C3C6=C(N=CC=C6)N)N

InChi

InChI=1S/C27H24N6/c28-24-21(8-4-17-30-24)25-32-23-14-13-22(18-6-2-1-3-7-18)31-26(23)33(25)20-11-9-19(10-12-20)27(29)15-5-16-27/h1-4,6-14,17H,5,15-16,29H2,(H2,28,30)

InChiKey

HNFMVVHMKGFCMB-UHFFFAOYSA-N

IUPAC Name

3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenylimidazo[4,5-b]pyridin-2-yl]pyridin-2-amine