Mirin, MRN-ATM complex inhibitor

Key facts

CAS number

1198097-97-0

Purity

>99%

Form

Solid

form

Molecular weight

220.25 Da

Molecular formula

C₁₀H₈N₂O₂S

PubChem

1206243

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one

Biological description

Mre11-Rad50-Nbs1 (MRN)-ATM complex inhibitor that blocks the 3' to 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC₅₀= 12 μM) and induces G₂ arrest in vitro.

Canonical smiles

C1=CC(=CC=C1C=C2C(=O)N=C(S2)N)O

Isomeric smiles

C1=CC(=CC=C1/C=C\2/C(=O)N=C(S2)N)O

InChi

InChI=1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-

InChiKey

YBHQCJILTOVLHD-YVMONPNESA-N

IUPAC Name

(5Z)-2-amino-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one