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MW 336.4 Da. Cell-permeable dynamin I and dynamin II inhibitor (IC50 values are 3.1 and 8.4 µM for inhibition of dynamin I and dynamin II GTPase, respectively). Targets the pleckstrin homology (PH) (lipid binding) domain. Competitive with phospholipid and non-competitive with GTP. Inhibits receptor-mediated and synaptic vesicle endocytosis (IC50 values are 19.9 and 2.2 µM, respectively). Inhibits cancer cell growth.
Alternative names=B dynamin, DNM, DNM 1, DYN1_HUMAN, Dynamin, Dynamin-1
- CAS number
1119-97-7
- Form
Solid
- Molecular weight
336.4 Da
- Molecular formula
C17H38BrN
- PubChem identifier
14250
- Nature
Synthetic
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MW 336.4 Da. Cell-permeable dynamin I and dynamin II inhibitor (IC50 values are 3.1 and 8.4 µM for inhibition of dynamin I and dynamin II GTPase, respectively). Targets the pleckstrin homology (PH) (lipid binding) domain. Competitive with phospholipid and non-competitive with GTP. Inhibits receptor-mediated and synaptic vesicle endocytosis (IC50 values are 19.9 and 2.2 µM, respectively). Inhibits cancer cell growth.
Alternative names=B dynamin, DNM, DNM 1, DYN1_HUMAN, Dynamin, Dynamin-1
Key facts
- CAS number
1119-97-7
- Form
Solid
- Molecular weight
336.4 Da
- Molecular formula
C17H38BrN
- PubChem identifier
14250
- Nature
Synthetic
- Biochemical name
Cetrimide
- Biological description
Cell-permeable dynamin I and dynamin II inhibitor (IC50 values are 3.1 and 8.4 µM for inhibition of dynamin I and dynamin II GTPase, respectively). Targets the pleckstrin homology (PH) (lipid binding) domain. Competitive with phospholipid and non-competitive with GTP. Inhibits receptor-mediated and synaptic vesicle endocytosis (IC50 values are 19.9 and 2.2 µM, respectively). Inhibits cancer cell growth.
- Canonical SMILES
CCCCCCCCCCCCCC[N+](C)(C)C.[Br-]
- InChI
InChI=1S/C17H38N.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18(2,3)4;/h5-17H2,1-4H3;1H/q+1;/p-1
- InChIKey
CXRFDZFCGOPDTD-UHFFFAOYSA-M
- IUPAC name
trimethyl(tetradecyl)azanium;bromide
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
Ambient
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Notes
Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. MiTMAB™ and OcTMAB™ are trademarks of Children's Medical Research Institute and Newcastle Innovation Ltd.
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