MW 334.33 Da, Purity >99%. Anticancer and antibiotic agent. Crosslinks DNA. Inhibits DNA synthesis and nuclear division. Also induces apoptosis.
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Publications
- Molecular medicine reports 28:2023Improvement of wound healing by capsaicin through suppression of the inflammatory response and amelioration of the repair process.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChi-Jung Huang,Chi-Ming Pu,Su-Yi Su,Shih-Lun Lo,Cheng Hung Lee,Yu-Hsiu YenPubMed 37387413
- Cell journal 25:255-2632023Fabrication of Cell-Laden AME-Loaded Collagen-Based Hydrogel Promotes Fibroblast Proliferation and Wound Healing .Applications:Unspecified applicationReactive species:Unspecified reactive speciesMohammad Azimi Lamouty,Niloufar Shayan Asl,Abdollah Safari,Marzieh Ebrahimi,Hamed DaemiPubMed 37210646
Key facts
- CAS number
50-07-7
- Purity
> 99%
- Form
Solid
- Source
Streptomyces sp.
- Molecular weight
334.33 Da
- Molecular formula
C15H18N4O5
- PubChem identifier
5746
- Nature
Native
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MW 334.33 Da, Purity >99%. Anticancer and antibiotic agent. Crosslinks DNA. Inhibits DNA synthesis and nuclear division. Also induces apoptosis.
Key facts
- CAS number
50-07-7
- Purity
> 99%
- Form
Solid
- Source
Streptomyces sp.
- Molecular weight
334.33 Da
- Molecular formula
C15H18N4O5
- PubChem identifier
5746
- Nature
Native
- Solubility
SOL IN WATER, METHANOL, BUTYL ACETATE, ACETONE, AND CYCLOHEXANONE; SLIGHTLY SOL IN BENZENE, ETHER, AND CARBON TETRACHLORIDE; PRACTICALLY INSOL IN PETROLEUM ETHER.
- Biochemical name
Mitomycin
- Biological description
Anticancer and antibiotic agent. Crosslinks DNA. Inhibits DNA synthesis and nuclear division. Also induces apoptosis.
- Canonical SMILES
CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N
- Isomeric SMILES
CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
- InChI
InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
- InChIKey
NWIBSHFKIJFRCO-WUDYKRTCSA-N
- IUPAC name
[(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
+4°C
- Storage information
The product can be stored for up to 12 months
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2 product images
Chemical Structure - Mitomycin C (MMC), Anticancer and antibiotic agent (ab120797)
2D chemical structure image of ab120797, Mitomycin C (MMC), Anticancer and antibiotic agent
Functional Studies - Mitomycin C (MMC), Anticancer and antibiotic agent (ab120797)
Functional assays: Caspase 8 (active) FITC Staining Kit (Caspase-8 (active) FITC Staining Kit ab65614)
Active caspase 8 in control Jurkat cells (10e6/mL) or cells treated for five hours with 10 ug/mL Cyclohexamide (CHX) (Cycloheximide, Protein synthesis inhibitor ab120093) or four hours with 25 ug/mL Mitomycin C (MitoC) (ab120797). Background signal subtracted, duplicates; +/- SD.
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