MW 334.33 Da, Purity >99%. Anticancer and antibiotic agent. Crosslinks DNA. Inhibits DNA synthesis and nuclear division. Also induces apoptosis.
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- Molecular medicine reports 28:2023Improvement of wound healing by capsaicin through suppression of the inflammatory response and amelioration of the repair process.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChi-Jung Huang,Chi-Ming Pu,Su-Yi Su,Shih-Lun Lo,Cheng Hung Lee,Yu-Hsiu YenPubMed 37387413
- Cell journal 25:255-2632023Fabrication of Cell-Laden AME-Loaded Collagen-Based Hydrogel Promotes Fibroblast Proliferation and Wound Healing .Applications:Unspecified applicationReactive species:Unspecified reactive speciesMohammad Azimi Lamouty,Niloufar Shayan Asl,Abdollah Safari,Marzieh Ebrahimi,Hamed DaemiPubMed 37210646
- Advanced healthcare materials 12:e22021472022Dynamically Crosslinked Poly(ethylene-glycol) Hydrogels Reveal a Critical Role of Viscoelasticity in Modulating Glioblastoma Fates and Drug Responses in 3D.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSauradeep Sinha,Manish Ayushman,Xinming Tong,Fan YangPubMed 36239185
- Cell reports 37:1100802021The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnnamaria Ruggiano,Bruno Vaz,Susan Kilgas,Marta Popović,Gonzalo Rodriguez-Berriguete,Abhay N Singh,Geoff S Higgins,Anne E Kiltie,Kristijan RamadanPubMed 34879279
- Small (Weinheim an der Bergstrasse, Germany) 17:e20014322020Fluorescent Silica Nanoparticles to Label Metastatic Tumor Cells in Mineralized Bone Microenvironments.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAaron E Chiou,Joshua A Hinckley,Rupal Khaitan,Neta Varsano,Jonathan Wang,Henry F Malarkey,Christopher J Hernandez,Rebecca M Williams,Lara A Estroff,Steve Weiner,Lia Addadi,Ulrich B Wiesner,Claudia FischbachPubMed 32462807
- Molecular medicine reports 16:7105-71112017A multi‑targeted tyrosine kinase inhibitor lenvatinib for the treatment of mice with advanced glioblastoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJia Li et. al.PubMed 28901423
- Advances in wound care 5:43-542016Type I and II Diabetic Adipose-Derived Stem Cells Respond to Dehydrated Human Amnion/Chorion Membrane Allograft Treatment by Increasing Proliferation, Migration, and Altering Cytokine Secretion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMichelle Massee,Kathryn Chinn,Jeremy J Lim,Lisa Godwin,Conan S Young,Thomas J KoobPubMed 26862462
Key facts
- CAS number
- 50-07-7
- Purity
- > 99%
- Form
- Solid
- Source
- Streptomyces sp.
- Molecular weight
- 334.33 Da
- Molecular formula
- C15H18N4O5
- PubChem identifier
- 5746
- Nature
- Native
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MW 334.33 Da, Purity >99%. Anticancer and antibiotic agent. Crosslinks DNA. Inhibits DNA synthesis and nuclear division. Also induces apoptosis.
Key facts
- CAS number
- 50-07-7
- Purity
- > 99%
- Form
- Solid
- Source
- Streptomyces sp.
- Molecular weight
- 334.33 Da
- Molecular formula
- C15H18N4O5
- PubChem identifier
- 5746
- Nature
- Native
- Solubility
Soluble in DMSO to 100 mM.
- Biochemical name
- Mitomycin
- Biological description
Anticancer and antibiotic agent. Crosslinks DNA. Inhibits DNA synthesis and nuclear division. Also induces apoptosis.
- Canonical SMILES
- CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N
- Isomeric SMILES
- CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
- InChI
- InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
- InChIKey
- NWIBSHFKIJFRCO-WUDYKRTCSA-N
- IUPAC name
- [(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- The product can be stored for up to 12 months
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2 product images
Chemical Structure - Mitomycin C (MMC), Anticancer and antibiotic agent (ab120797)
2D chemical structure image of ab120797, Mitomycin C (MMC), Anticancer and antibiotic agent
Functional Studies - Mitomycin C (MMC), Anticancer and antibiotic agent (ab120797)
Functional assays: Caspase 8 (active) FITC Staining Kit (Caspase-8 (active) FITC Staining Kit ab65614)Active caspase 8 in control Jurkat cells (10e6/mL) or cells treated for five hours with 10 ug/mL Cyclohexamide (CHX) (Cycloheximide, Protein synthesis inhibitor ab120093) or four hours with 25 ug/mL Mitomycin C (MitoC) (ab120797). Background signal subtracted, duplicates; +/- SD.
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