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AB120797

Mitomycin C (MMC), Anticancer and antibiotic agent

5

(1 Review)

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(8 Publications)

MW 334.33 Da, Purity >99%. Anticancer and antibiotic agent. Crosslinks DNA. Inhibits DNA synthesis and nuclear division. Also induces apoptosis.
2 Images
Functional Studies - Mitomycin C (MMC), Anticancer and antibiotic agent (AB120797)
  • FuncS

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Functional Studies - Mitomycin C (MMC), Anticancer and antibiotic agent (AB120797)

Functional assays : Caspase 8 (active) FITC Staining Kit (ab65614)

Active caspase 8 in control Jurkat cells (10e6/mL) or cells treated for five hours with 10 ug/mL Cyclohexamide (CHX) (ab120093) or four hours with 25 ug/mL Mitomycin C (MitoC) (ab120797). Background signal subtracted, duplicates; +/- SD.

Chemical Structure - Mitomycin C (MMC), Anticancer and antibiotic agent (AB120797)
  • Chemical Structure

Lab

Chemical Structure - Mitomycin C (MMC), Anticancer and antibiotic agent (AB120797)

2D chemical structure image of ab120797, Mitomycin C (MMC), Anticancer and antibiotic agent

Key facts

CAS number

50-07-7

Purity

>99%

Form

Solid

form

Source

Streptomyces sp.

Molecular weight

334.33 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>8</sub>N<sub>4</sub>O<sub>5</sub>

PubChem

5746

Nature

Native

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Mitomycin

Biological description

Anticancer and antibiotic agent. Crosslinks DNA. Inhibits DNA synthesis and nuclear division. Also induces apoptosis.

Canonical smiles

CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N

Isomeric smiles

CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N

InChi

InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1

InChiKey

NWIBSHFKIJFRCO-WUDYKRTCSA-N

IUPAC Name

[(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate

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Primary Antibodies

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Primary Antibodies

AB27156

Anti-ds DNA antibody [35I9 DNA] - BSA and Azide free

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ds DNA antibody [35I9 DNA] - BSA and Azide free (AB27156)

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Primary Antibodies

AB48508

Anti-8-Hydroxy-2'-deoxyguanosine antibody [N45.1]

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 44:115259 PubMed39893637

2025

The homologous recombination factors BRCA2 and PALB2 interplay with mismatch repair pathways to maintain centromere stability and cell viability.

Applications

Unspecified application

Species

Unspecified reactive species

Emily Graham,Lucia Rampazzo,Chin Wei Brian Leung,Jacob Wall,Emőke Zsanett Gerőcz,Mikhail Liskovykh,Nikolay Goncharov,Xanita Saayman,Ramazan Gundogdu,Masato T Kanemaki,Hiroshi Masumoto,Vladimir Larionov,Natalay Kouprina,Fumiko Esashi

Molecular medicine reports 28: PubMed37387413

2023

Improvement of wound healing by capsaicin through suppression of the inflammatory response and amelioration of the repair process.

Applications

Unspecified application

Species

Unspecified reactive species

Chi-Jung Huang,Chi-Ming Pu,Su-Yi Su,Shih-Lun Lo,Cheng Hung Lee,Yu-Hsiu Yen

Cell journal 25:255-263 PubMed37210646

2023

Fabrication of Cell-Laden AME-Loaded Collagen-Based Hydrogel Promotes Fibroblast Proliferation and Wound Healing .

Applications

Unspecified application

Species

Unspecified reactive species

Mohammad Azimi Lamouty,Niloufar Shayan Asl,Abdollah Safari,Marzieh Ebrahimi,Hamed Daemi

Advanced healthcare materials 12:e2202147 PubMed36239185

2022

Dynamically Crosslinked Poly(ethylene-glycol) Hydrogels Reveal a Critical Role of Viscoelasticity in Modulating Glioblastoma Fates and Drug Responses in 3D.

Applications

Unspecified application

Species

Unspecified reactive species

Sauradeep Sinha,Manish Ayushman,Xinming Tong,Fan Yang

Cell reports 37:110080 PubMed34879279

2021

The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability.

Applications

Unspecified application

Species

Unspecified reactive species

Annamaria Ruggiano,Bruno Vaz,Susan Kilgas,Marta Popović,Gonzalo Rodriguez-Berriguete,Abhay N Singh,Geoff S Higgins,Anne E Kiltie,Kristijan Ramadan

Small (Weinheim an der Bergstrasse, Germany) 17:e2001432 PubMed32462807

2020

Fluorescent Silica Nanoparticles to Label Metastatic Tumor Cells in Mineralized Bone Microenvironments.

Applications

Unspecified application

Species

Unspecified reactive species

Aaron E Chiou,Joshua A Hinckley,Rupal Khaitan,Neta Varsano,Jonathan Wang,Henry F Malarkey,Christopher J Hernandez,Rebecca M Williams,Lara A Estroff,Steve Weiner,Lia Addadi,Ulrich B Wiesner,Claudia Fischbach

Molecular medicine reports 16:7105-7111 PubMed28901423

2017

A multi‑targeted tyrosine kinase inhibitor lenvatinib for the treatment of mice with advanced glioblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Li,Chang-Lin Zou,Zhi-Ming Zhang,Lian-Jie Lv,Hai-Bo Qiao,Xiu-Ju Chen

Advances in wound care 5:43-54 PubMed26862462

2016

Type I and II Diabetic Adipose-Derived Stem Cells Respond to Dehydrated Human Amnion/Chorion Membrane Allograft Treatment by Increasing Proliferation, Migration, and Altering Cytokine Secretion.

Applications

Unspecified application

Species

Unspecified reactive species

Michelle Massee,Kathryn Chinn,Jeremy J Lim,Lisa Godwin,Conan S Young,Thomas J Koob
View all publications
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