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MW 760.46 g/mol, Purity >95%. Ratiometric, fluorescent, mitochondria-targeted lipid peroxidation probe. Derived from the C11-BODIPY(581/591) probe, which contains a boron dipyromethane difluoride (BODIPY) fluorophore conjugated via a dienyl link to a phenyl group. An attached triphenylphosphonium lipophilic cation leads to selective uptake into mitochondria in living cells, driven by the mitochondrial membrane potential. In response to lipid peroxidation the fluorescence emission maximum shifts from ∼590 to ∼520 nm.


Images

Chemical Structure - MitoPerOx, fluorescent mitochondria-targeted lipid peroxidation probe (AB146820), expandable thumbnail

Publications

Key facts

CAS number
1392820-50-6
Purity
> 95%
Form
Solid
Molecular weight
760.46 g/mol
Molecular formula
C42H38BF2N3OP.Br
Nature
Synthetic
Excitation/Emission
Em: 590nm

Target data

Recommended products

MW 760.46 g/mol, Purity >95%. Ratiometric, fluorescent, mitochondria-targeted lipid peroxidation probe. Derived from the C11-BODIPY(581/591) probe, which contains a boron dipyromethane difluoride (BODIPY) fluorophore conjugated via a dienyl link to a phenyl group. An attached triphenylphosphonium lipophilic cation leads to selective uptake into mitochondria in living cells, driven by the mitochondrial membrane potential. In response to lipid peroxidation the fluorescence emission maximum shifts from ∼590 to ∼520 nm.

Key facts

Purity
> 95%
Solubility

Soluble in DMSO to 25 mM.

Biological description

Ratiometric, fluorescent, mitochondria-targeted lipid peroxidation probe. Derived from the C11-BODIPY(581/591) probe, which contains a boron dipyromethane difluoride (BODIPY) fluorophore conjugated via a dienyl link to a phenyl group. An attached triphenylphosphonium lipophilic cation leads to selective uptake into mitochondria in living cells, driven by the mitochondrial membrane potential. In response to lipid peroxidation the fluorescence emission maximum shifts from ∼590 to ∼520 nm.

Isomeric SMILES
[BR-].F[B-]7(F)[N+]=2C(C=CC=2\C=C\C=C\C1CCCCC1)=CC6CCC(CCC(=O)NCC[P+](C3CCCCC3)(C4CCCCC4)C5CCCCC5)N67
InChI
InChI=1S/C42H37BF2N3OP.BrH/c44-43(45)47-35(18-14-13-17-34-15-5-1-6-16-34)25-27-37(47)33-38-28-26-36(48(38)43)29-30-42(49)46-31-32-50(39-19-7-2-8-20-39,40-21-9-3-10-22-40)41-23-11-4-12-24-41;/h1-28,33H,29-32H2;1H/b17-13+,18-14+;
InChIKey
UDTNTHFRCJAKLR-GPSHETCQNA-N
IUPAC name
4,4-Difluoro-5-(4-phenyl-1,3-butadienyl)-4-bora-3a,4a-diaza-s-indacene-3-(propionylaminoethylentriphenylphosphonium) bromide
Excitation/Emission
Em: 590nm

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark

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1 product image

  • Chemical Structure - MitoPerOx, fluorescent mitochondria-targeted lipid peroxidation probe (ab146820), expandable thumbnail

    Chemical Structure - MitoPerOx, fluorescent mitochondria-targeted lipid peroxidation probe (ab146820)

    2D chemical structure image of ab146820, MitoPerOx, fluorescent mitochondria-targeted lipid peroxidation probe

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Product protocols

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