MW 954.5 Da, Purity >98%. Selective, mitochondria-targeted redox cycler. Selectively increases superoxide production within the mitochondrial matrix in vitro and in vivo. Comprises a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat.
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- Frontiers in immunology 13:9185512022Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGisela Jimenez-Duran,Joseph Kozole,Rachel Peltier-Heap,Eleanor R Dickinson,Christopher R Kwiatkowski,Francesca Zappacosta,Roland S Annan,Nicholas W Galwey,Eva-Maria Nichols,Louise K Modis,Martha Triantafilou,Kathy Triantafilou,Lee M BootyPubMed 36248901
- Cell stem cell 29:1315-1332.e92022The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNicole Baker,Steven Wade,Matthew Triolo,John Girgis,Damian Chwastek,Sarah Larrigan,Peter Feige,Ryo Fujita,Colin Crist,Michael A Rudnicki,Yan Burelle,Mireille KhachoPubMed 35998642
- Cell reports 34:1087232021An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPedro Gonzalez-Menendez,Manuela Romano,Hongxia Yan,Ruhi Deshmukh,Julien Papoin,Leal Oburoglu,Marie Daumur,Anne-Sophie Dumé,Ira Phadke,Cédric Mongellaz,Xiaoli Qu,Phuong-Nhi Bories,Michaela Fontenay,Xiuli An,Valérie Dardalhon,Marc Sitbon,Valérie S Zimmermann,Patrick G Gallagher,Saverio Tardito,Lionel Blanc,Narla Mohandas,Naomi Taylor,Sandrina KinetPubMed 33535038
- Scientific reports 11:8552021Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShady Estfanous et. al.PubMed 33441602
- Redox biology 34:1015472020The mitochondrial peroxiredoxin displays distinct roles in different developmental stages of African trypanosomes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarta Bogacz et. al.PubMed 32388269
- Cell 177:1201-1216.e192019Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDenis A Mogilenko et. al.PubMed 31031005
- Cell chemical biology 26:449-461.e82019Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLee M Booty et. al.PubMed 30713096
- Cell metabolism 28:145-158.e42018Acute O Sensing: Role of Coenzyme QH/Q Ratio and Mitochondrial ROS Compartmentalization.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIgnacio Arias-Mayenco,Patricia González-Rodríguez,Hortensia Torres-Torrelo,Lin Gao,M Carmen Fernández-Agüera,Victoria Bonilla-Henao,Patricia Ortega-Sáenz,José López-BarneoPubMed 29887397
- Cell chemical biology 24:1285-1298.e122017MitoNeoD: A Mitochondria-Targeted Superoxide Probe.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaria M Shchepinova,Andrew G Cairns,Tracy A Prime,Angela Logan,Andrew M James,Andrew R Hall,Sara Vidoni,Sabine Arndt,Stuart T Caldwell,Hiran A Prag,Victoria R Pell,Thomas Krieg,John F Mulvey,Pooja Yadav,James N Cobley,Thomas P Bright,Hans M Senn,Robert F Anderson,Michael P Murphy,Richard C HartleyPubMed 28890317
Key facts
- CAS number
- 1821370-28-8
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 954.5 Da
- Molecular formula
- C39H46I3N2P
- PubChem identifier
- 129909777
- Nature
- Synthetic
Target data
Recommended products
MW 954.5 Da, Purity >98%. Selective, mitochondria-targeted redox cycler. Selectively increases superoxide production within the mitochondrial matrix in vitro and in vivo. Comprises a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat.
Key facts
- CAS number
- 1821370-28-8
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 954.5 Da
- Molecular formula
- C39H46I3N2P
- PubChem identifier
- 129909777
- Nature
- Synthetic
- Solubility
Soluble in ethanol to 10 mM.
Soluble in DMSO to 100 mM.
- Biochemical name
- MitoPQ
- Biological description
Selective, mitochondria-targeted redox cycler. Selectively increases superoxide production within the mitochondrial matrix in vitro and in vivo. Comprises a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat.
- Canonical SMILES
- C[N+]1=CC=C(C=C1)C2=CC=[N+](C=C2)CCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[I-].[I-].[I-]
- InChI
- InChI=1S/C39H46N2P.3HI/c1-40-30-25-35(26-31-40)36-27-32-41(33-28-36)29-17-6-4-2-3-5-7-18-34-42(37-19-11-8-12-20-37,38-21-13-9-14-22-38)39-23-15-10-16-24-39;;;/h8-16,19-28,30-33H,2-7,17-18,29,34H2,1H3;3*1H/q+3;;;/p-3
- InChIKey
- AOZZGHKENAZYTD-UHFFFAOYSA-K
- IUPAC name
- 10-[4-(1-methylpyridin-1-ium-4-yl)pyridin-1-ium-1-yl]decyl-triphenylphosphanium;triiodide
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions
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1 product image
Chemical Structure - MitoPQ, mitochondria-targeted redox cycler (ab146819)
2D chemical structure image of ab146819, MitoPQ, mitochondria-targeted redox cycler
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