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AB285406

Mitoquinone

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(4 Publications)

MW 583.7 Da, Purity >98%. Mitoquinone is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects. Displays beneficial effects in mouse models of Alzheimer's disease. Mitoquinone protects pancreatic β-cells against oxidative stress and improves insulin secretion. Cell-permeable.

Key facts

CAS number

444890-41-9

Purity

>98%

Form

Solid

form

Molecular weight

583.7 Da

Molecular formula

C<sub>3</sub><sub>7</sub>H<sub>4</sub><sub>4</sub>O<sub>4</sub>P+

PubChem

11388332

Nature

Synthetic

Solubility

Soluble in DMSO

Biochemical name

Mitoquinone

Biological description

Mitoquinone is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects. Displays beneficial effects in mouse models of Alzheimer's disease. Mitoquinone protects pancreatic β-cells against oxidative stress and improves insulin secretion. Cell-permeable.

Canonical smiles

CC1=C(C(=O)C(=C(C1=O)OC)OC)CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4

InChi

InChI=1S/C37H44O4P/c1-29-33(35(39)37(41-3)36(40-2)34(29)38)27-19-8-6-4-5-7-9-20-28-42(30-21-13-10-14-22-30,31-23-15-11-16-24-31)32-25-17-12-18-26-32/h10-18,21-26H,4-9,19-20,27-28H2,1-3H3/q+1

InChiKey

OIIMUKXVVLRCAF-UHFFFAOYSA-N

IUPAC Name

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl-triphenylphosphanium

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called B1309 Mitoquinone. B1309-25 is the same size as the 25 mg size of ab285406.
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
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Product protocols

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Orphanet journal of rare diseases 20:195 PubMed40275410

2025

Using chanarin-dorfman syndrome patient fibroblasts to explore disease mechanisms and new treatment avenues.

Applications

Unspecified application

Species

Unspecified reactive species

Mor Angel,Yuval Kleinberg,Tanmoy Newaz,Victoria Li,Rinat Zaid,Keren Oved,Orly Dorot,Edward Pichinuk,Emily Avitan-Hersh,Ann Saada,Karin Weiss,Vanina Zaremberg,Galit Tal,Einat Zalckvar

Science advances 11:eadq7307 PubMed39841829

2025

Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion.

Applications

Unspecified application

Species

Unspecified reactive species

Alessia Zotta,Juliana Toller-Kawahisa,Eva M Palsson-McDermott,Shane M O'Carroll,Órlaith C Henry,Emily A Day,Anne F McGettrick,Ross W Ward,Dylan G Ryan,Mark A Watson,Martin D Brand,Marah C Runtsch,Kathrin Maitz,Anna Lueger,Julia Kargl,Jan L Miljkovic,Ed C Lavelle,Luke A J O'Neill

International journal of molecular sciences 24: PubMed37834219

2023

Mitoquinone Alleviates Donation after Cardiac Death Kidney Injury during Hypothermic Machine Perfusion in Rat Model.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Radajewska,Jakub Szyller,Anna Krzywonos-Zawadzka,Agnieszka Olejnik,Grzegorz Sawicki,Iwona Bil-Lula

Redox biology 57:102507 PubMed36244294

2022

Inhibition of mitochondrial complex I leading to NAD/NADH imbalance in type 2 diabetic patients who developed late stent thrombosis: Evidence from an integrative analysis of platelet bioenergetics and metabolomics.

Applications

Unspecified application

Species

Unspecified reactive species

Mi-Jie Gao,Ning-Hua Cui,Xia'nan Liu,Xue-Bin Wang
View all publications
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