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MW 517.4 Da, Purity >98%. Type II topoisomerase inhibitor (IC50 = 50 nM). Able to inhibit DNA and protein synthesis, and induce both DNA strand breakage and cross linkage. Antineoplastic, immunomodulatory and chemotherapeutic action.

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Chemical Structure - Mitoxantrone dihydrochloride, Type II topoisomerase inhibitor (AB141041), expandable thumbnail

Publications

Key facts

CAS number
70476-82-3
Purity
> 98%
Form
Solid
Molecular weight
517.4 Da
Molecular formula
C22H30Cl2N4O6
PubChem identifier
51082
Nature
Synthetic

Alternative names

Recommended products

MW 517.4 Da, Purity >98%. Type II topoisomerase inhibitor (IC50 = 50 nM). Able to inhibit DNA and protein synthesis, and induce both DNA strand breakage and cross linkage. Antineoplastic, immunomodulatory and chemotherapeutic action.

Key facts

Purity
> 98%
PubChem identifier
51082
Solubility

pH 9 Borate buffer < 1 (mg/mL).

Soluble in DMSO to 100 mM.

Soluble in water to 10 mM.

Biochemical name
Mitoxantrone hydrochloride
Biological description

Type II topoisomerase inhibitor (IC50 = 50 nM). Able to inhibit DNA and protein synthesis, and induce both DNA strand breakage and cross linkage. Antineoplastic, immunomodulatory and chemotherapeutic action.

Canonical SMILES
C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl
InChI
InChI=1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
InChIKey
ZAHQPTJLOCWVPG-UHFFFAOYSA-N
IUPAC name
1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione;dihydrochloride

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - Mitoxantrone dihydrochloride, Type II topoisomerase inhibitor (ab141041), expandable thumbnail

    Chemical Structure - Mitoxantrone dihydrochloride, Type II topoisomerase inhibitor (ab141041)

    2D chemical structure image of ab141041, Mitoxantrone dihydrochloride, Type II topoisomerase inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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