MK-1775

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MW 500.6 Da, Purity >98%. Potent and selective small-molecule inhibitor of Wee1 kinase. Inhibits Wee1 (IC₅₀ = 5.2 nM) in cell-free assays. Inhibits phosphorylation of CDC2 at Tyr15 (CDC2Y15), a direct substrate of Wee1 kinase in cell-based assays. Acts synergistically with gemcitabine in tumor cells. In a panel of 223 kinases, only 8 were inhibited >80% by 1μM MK-1775.

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2310026J05Rik, 2610005A10Rik, 2610017K16Rik, 5033405D03Rik, ABL, ABL proto oncogene 1 non receptor tyrosine kinase, ABL1_HUMAN, ADCK1_HUMAN, ADK_HUMAN, AI255373, AI987814, AK, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine protein kinase 1, Adenosine 5''-phosphotransferase, Adenosine kinase, Auxilin 2, BCR/ABL FUSION GENE, INCLUDED, BCR/FGFR1 FUSION GENE, INCLUDED, BCR/FGFR1 chimera protein, BCR/PDGFRA FUSION GENE, INCLUDED, BCR1, BCR_HUMAN, BOS_11212, Bcr/c abl oncogene protein, Breakpoint cluster region, Breakpoint cluster region protein, CDK16_HUMAN, CK II, CK II alpha', CK2A2, CML, CSK22_HUMAN, Casein kinase 2 alpha prime polypeptide, Casein kinase II alpha' chain, Casein kinase II subunit alpha', Cell cycle regulated protein kinase, Cell division protein kinase 16, Cellular Yes 1 protein, Cyclin-G-associated kinase, Cyclin-dependent kinase 16, D22S11, D22S662, DKFZp547K1610, DKFZp686I18166, DNAJ26, DNAJC26, Dual specificity mitogen-activated protein kinase kinase 4, EC 2.7.10.2, EC 2.7.11.1, EC 2.7.11.25, EPH receptor B6, EPHB6_HUMAN, Ephrin type B receptor 6 precursor, Ephrin type-B receptor 6, FGFR1/BCR chimera protein, FLJ11330, FLJ16446, FLJ16629, FLJ20093, FLJ39600, FLJ40395, FLJ43934, FTDALS4, GAK protein, GAK_HUMAN, HEP, HSPK 36, HsT441, I-kappa-B kinase epsilon, IKK related kinase epsilon, IKK-epsilon, IKK-i, IKKE_HUMAN, IkBKE, Inducible I kappa-B kinase, Inhibitor of kappa light polypeptide gene enhancer in B cells kinase epsilon, Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase of, epsilon, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, JAK L, JAK2_HUMAN, JAK3 HUMAN, JAK3_HUMAN, JNK Activated Kinase 1, JNK-activating kinase 1, JNKK, JNKK-1, JTK 10, JTK7, Janus Activating Kinase 2, Janus kinase 2, Janus kinase 2 (a protein tyrosine kinase), Janus kinase 3, Janus kinase 3 (a protein tyrosine kinase, leukocyte), KIAA0151, L-JAK, Leukocyte janus kinase, M3K11_HUMAN, MAP kinase kinase 4, MAP2K4, MAPK / ERK kinase 4, MAPKK-4, MEK-4, MEKK11, MGC105683, MGC125294, MGC125295, MGC125297, MGC129910, MGC129911, MGC142877, MGC17114, MGC6593, MGC99654, MKK-4, Map3k11, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, Mitogen activated protein kinase kinase 4, Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Mixed lineage protein kinase 3, Myt1 kinase, NAK, NEK3_HUMAN, NF kB activating kinase, NF-kappa-B-activating kinase, NIMA (never in mitosis gene a) related kinase 3, Never in mitosis A-related kinase 3, NimA-related protein kinase 3, OTTHUMP00000019864, OTTHUMP00000019865, OTTHUMP00000043260, OTTHUMP00000231338, OTTHUMP00000231339, P150, PCTAIRE, PCTAIRE protein kinase 1, PCTAIRE-motif protein kinase 1, PCTGAIRE, PCTK1, PLK, PLK1_HUMAN, PMYT1_HUMAN, PPP1R126, PRKMK-4, PTK1, Polo-like kinase 1, Protein kinase Myt1, Protein kinase membrane associated tyrosine/threonine 1, Protein phosphatase 1 regulatory subunit 126, Protein tyrosine kinase PTK1, Protein tyrosine kinase leukocyte, Proto oncogene tyrosine protein kinase ABL1, Proto oncogene tyrosine protein kinase YES, Proto-oncogene c-Abl, Proto-oncogene c-Yes, RHOE, Renal carcinoma antigen NY-REN-26, SAPK / ERK kinase 1, SEK 1, SERK-1, SH3 domain containing proline rich kinase, SPRK, STPK 13, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase Nek3, Serine/threonine-protein kinase PCTAIRE-1, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase TBK1, Src-homology 3 domain-containing proline-rich kinase, T2K, TANK-binding kinase 1, TBK1_HUMAN, THCYT3, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase JAK3, Tyrosine-protein kinase Yes, Tyrosine-protein kinase-defective receptor EPH-6, Uncharacterized aarF domain-containing protein kinase 1, Viral oncogene yes 1 homolog 1, WEE 1 homolog 1 (S. pombe), WEE1 homolog (S. pombe), WEE1 homolog 2 (S. pombe), WEE1 homolog S. pombe, WEE1, S. pombe, homolog of, WEE1, somatic, WEE1A, WEE1B, WEE1_HUMAN, WEE1hu, WEE2_HUMAN, Wee1 homolog, Wee1 tyrosine kinase, Wee1+ S. pombe homolog, Wee1+ homolog, Wee1-like protein kinase, Wee1-like protein kinase 1B, Wee1-like protein kinase 2, Wee1A kinase, Wee1B kinase, YES proto oncogene 1, Src family tyrosine kinase, YES1 proto oncogene, Src family tyrosine kinase, YES_HUMAN, Yamaguchi sarcoma oncogene, Yes 1, aarF domain containing kinase 1, bcr/abl, c ABL, c Yes, c abl oncogene 1 non receptor tyrosine kinase, c abl oncogene 1 receptor tyrosine kinase, c-Jun N-terminal kinase kinase 1, cdc2 inhibitory kinase, hCG_39453, kinase Jak2, p61-Yes, v abl, v abl Abelson murine leukemia viral oncogene homolog 1, v yes 1 Yamaguchi sarcoma viral oncogene homolog 1