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AB223883

MK-8931, Beta-sectetase inhibitor

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MW 409.4 Da, Purity >98%. MK-8931 is a selective, potent Beta-sectetase 1 inhibitor (IC50 = 2.2 nM).

View Alternative Names

ALP 56, APP beta secretase, ASP21, Asp 1, Asp 2, Aspartic-like protease 56 kDa, Aspartyl protease 1, Aspartyl protease 2, BACE, BACE1_HUMAN, BACE2_HUMAN, Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2, Beta secretase, Beta site APP cleaving enzyme, Beta site amyloid beta A4 precursor protein cleaving enzyme, Beta site amyloid precursor protein cleaving enzyme, Beta-secretase 1, Beta-secretase 2, Beta-site APP cleaving enzyme 1, Beta-site APP cleaving enzyme 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 2, DRAP, Down region aspartic protease, Downs Syndrome Region Aspartic Protease, FLJ90568, HSPC104, Memapsin-1, Memapsin-2, Membrane-associated aspartic protease 1, Membrane-associated aspartic protease 2, Theta-secretase, Transmembrane aspartic proteinase Asp2

1 Images
Chemical Structure - MK-8931, Beta-sectetase inhibitor (AB223883)
  • Chemical Structure

Lab

Chemical Structure - MK-8931, Beta-sectetase inhibitor (AB223883)

2D chemical structure image of ab223883, MK-8931, Beta-sectetase inhibitor

Key facts

CAS number

1286770-55-5

Purity

>98%

Form

Solid

form

Molecular weight

409.4 Da

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>7</sub>F<sub>2</sub>N<sub>5</sub>O<sub>3</sub>S

PubChem

51352361

Nature

Synthetic

Solubility

Soluble in DMSO to 75 mM

Biochemical name

Verubecestat

Biological description

MK-8931 is a selective, potent Beta-sectetase 1 inhibitor (IC50 = 2.2 nM).

Canonical smiles

CC1(CS(=O)(=O)N(C(=N1)N)C)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)F)F

Isomeric smiles

C[C@]1(CS(=O)(=O)N(C(=N1)N)C)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)F)F

InChi

InChI=1S/C17H17F2N5O3S/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)/t17-/m0/s1

InChiKey

YHYKUSGACIYRML-KRWDZBQOSA-N

IUPAC Name

N-[3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called B1315 MK-8931. B1315-5 is the same size as the 5 mg size of ab223883.

Protect from air and light.

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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

BACE1 and BACE2 also known as beta-secretase 1 and 2 are enzymes involved in the cleavage of amyloid precursor protein (APP). BACE1 with a mass of around 75 kDa is expressed mainly in neuronal tissues while BACE2 is found in various tissues including the brain and pancreas. These enzymes catalyze the initial step in the production of beta-amyloid peptides by cleaving APP at the beta-site. This enzymatic activity suggests critical roles in cellular processes especially in neural function and integrity.
Biological function summary

BACE1 and BACE2 serve as key players in neurodegenerative pathways. They are known to form part of the gamma-secretase complex participating in the proteolytic processing of APP leading to the formation of amyloid-beta peptides. These peptides have significant implications in cell signaling and neuronal functions contributing to synaptic plasticity and overall brain health. BACE2 also has roles in pigment cell biology indicating its additional functions beyond the nervous system.

Pathways

BACE1 and BACE2 are integral to the amyloidogenic pathway a central route in the pathogenesis of Alzheimer's disease. They are related to proteins such as APP and presenilin which influence the generation of amyloid-beta peptides. Another important pathway involving BACE1 is the Notch signaling pathway where its activity can influence cellular differentiation processes.

BACE1 and BACE2 are closely linked to Alzheimer's disease and possible involvement in type 2 diabetes. Alzheimer's disease is characterized by the accumulation of amyloid-beta plaques which are a direct result of BACE1 activity. Proteins like APP and tau are connected to the pathophysiology seen in such neurodegenerative disorders. Additionally alterations in BACE2 are associated with metabolic processes that could influence glucose homeostasis implicating it in metabolic disorders like diabetes.
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Product protocols

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