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MW 494.1 Da, Purity >98%. Potent 5-lipoxygenase activating protein inhibitor (FLAP) (IC50 = 44 nM). Inhibits leukotriene biosynthesis (IC50 = 2.5 nM) in vitro and tumor activity in vivo. Displays PPARα antagonist activity. Orally active in vivo.
Alternative names=(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, 1,8-cineole 2-exo-monooxygenase, 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase, 3-oxoacyl-[acyl-carrier-protein] reductase, 3-oxoacyl-[acyl-carrier-protein] synthase, 41 kDa ubiquitin-specific protease, 5-LO, 5-LOX, 5-lipoxygenase, 5LPG, ALOX 5, Albendazole monooxygenase, Albendazole sulfoxidase, Arachidonate 5-lipoxygenase, Arachidonic acid 5 lipoxygenase, BDPLT14, BLM_HUMAN, BS, Bloom syndrome, Bloom syndrome RecQ helicase like, Bloom syndrome protein, CAMP GEFI, CGEF 1, CP2C9_HUMAN, CP33, CP34, CP3A4_HUMAN, CPC9, CYP2C, CYP2C10, CYP3, CYP3A, CYP3A3, CYP3A4, CYP5, CYP5A1, CYPIIC9, CYPIIIA3, CYPIIIA4, Cell cycle regulated protein kinase, Cytochrome P-450MP, Cytochrome P450 2C9, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 5A1, Cytochrome P450 HLp, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 NF-25, Cytochrome P450 PB-1, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450, family 2, subfamily C, polypeptide 9, Cytochrome P450, family 5, subfamily A, polypeptide 1, Cytochrome P450-PCN1, Cytosolic NADP-isocitrate dehydrogenase, DINB protein, DINB1, DINP, DKFZp686C2056, DNA damage inducible protein b, DNA directed DNA polymerase beta, DNA helicase, DNA helicase RecQ like type 2, DNA helicase, RecQ like type 3, DNA pol beta, DNA polymerase beta, DNA polymerase beta subunit, DNA polymerase eta, DNA polymerase iota, DNA polymerase kappa, DNA replication inhibitor, DPOLB_HUMAN, Deubiquitinating enzyme 2, DinB homolog 1 (E. coli), EPA1, EPAC, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ESRL 1, ESRR A, Enoyl-[acyl-carrier-protein] reductase, Epac 1, Epididymis luminal protein 216, Epididymis secretory protein Li 26, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen-related receptor alpha, Estrra, Eta 2, Exchange factor directly activated by cAMP 1, Exchange protein directly activated by cAMP 1, Exonuclease WRN, FASN, FAS_HUMAN, FLJ16395, FLJ21978, FLJ52771, Fatty acid synthase, GEMI_HUMAN, GHOSAL, GLP-1 receptor, GLP1R_HUMAN, GMNN, Geminin, Geminin DNA replication inhibitor, Glucagon-like peptide 1 receptor, Glucocorticoid inducible P450, HEL-216, HEL-S-26, HGNC 12791, HLP, ICDH, IDCD, IDH, IDH1, IDHC_HUMAN, IDP, IDPC, Isocitrate dehydrogenase (NADP(+)) 1 cytosolic, Isocitrate dehydrogenase 1 (NADP+) soluble, Isocitrate dehydrogenase [NADP] cytoplasmic, LOG 5, LOX5_HUMAN, Leukotriene A4 synthase, MGC125976, MGC126616, MGC126680, MGC131618, MGC131620, MGC138331, MGC14367, MGC149605, MGC15706, MGC163204, MGC21410, MGC88320, Microsomal monooxygenase, NADP dependent isocitrate dehydrogenase cytosolic, NADP dependent isocitrate dehydrogenase peroxisomal, NADP(+)-specific ICDH, NF 25, NR3B1, Nifedipine oxidase, Nuclear receptor subfamily 3 group B member 1, OA 519, OTTHUMP00000016340, OTTHUMP00000020135, OTTHUMP00000039393, OTTHUMP00000225301, Oleoyl-[acyl-carrier-protein] hydrolase, Oxalosuccinate decarboxylase, P450 III steroid inducible, P450 MP, P450 PB 1, P450 PCN1, P450, family III, P450C3, P450IIC9, PICD, PLK, PLK1_HUMAN, POLH_HUMAN, POLI_HUMAN, POLK_HUMAN, POLQ, Platelet cytochrome P450 subfamily V, Pol B, Pol beta, Polo-like kinase 1, Polymerase (DNA directed) beta, Polymerase (DNA directed) iota, Polymerase (DNA directed) kappa, Quinine 3-monooxygenase, RAD 30B, RAD30, RAD30 homolog A, RAD30 homolog B, RAD30, S. cerevisiae, homolog of, RAD30A, RAD3OB, RAP guanine nucleotide exchange factor, RAP guanine nucleotide exchange factor 3, RAPGEF3, RECQ 2, RECQ like, RECQL 2, RECQL 3, RP3 369A17.3, Rap guanine nucleotide exchange factor (GEF) 3, Rap1 guanine nucleotide exchange factor directly activated by cAMP, RecQ protein-like 2, RecQ protein-like 3, RecQ-like type 2, RecQ-like type 3, RecQ3, S-mephenytoin 4-hydroxylase, SDR27X1, STPK 13, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase PLK1, Short chain dehydrogenase/reductase family 27X member 1, Steroid hormone receptor ERR1, THAS_HUMAN, TS, TXA synthase, TXAS, TXS, Taurochenodeoxycholate 6-alpha-hydroxylase, Tbxas1, Thromboxane A synthase 1, Thromboxane A synthase 1 (platelet), Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A), Thromboxane A synthase 1 platelet cytochrome P450 subfamily V, Thromboxane-A synthase, UBP-t, UBP2_HUMAN, UBP41, USP9, Ubiquitin carboxyl-terminal hydrolase 2, Ubiquitin specific protease 12, Ubiquitin specific protease, 41kD, Ubiquitin thioesterase 2, Ubiquitin thiolesterase 2, Ubiquitin-specific protease 9, Ubiquitin-specific-processing protease 2, Ubiquitin-specific-processing protease testis, WRN_HUMAN, Werner syndrome ATP-dependent helicase, Werner syndrome helicase, Werner syndrome protein, Werner syndrome, RecQ helicase like, XP V, Xenobiotic monooxygenase, Xeroderma pigmentosum variant type protein, [Acyl-carrier-protein] S acetyltransferase, [Acyl-carrier-protein] S malonyltransferase, arachidonic 5-lipoxygenase alpha-10 isoform, arachidonic 5-lipoxygenase delta-10-13 isoform, arachidonic 5-lipoxygenase delta-13 isoform, arachidonic 5-lipoxygenase delta-p10 isoform, bcm910, cAMP regulated guanine nucleotide exchange factor I, cytochrome P-450 S-mephenytoin 4-hydroxylase, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, estrogen receptor related receptor alpha, flavoprotein-linked monooxygenase, hERR1, polymerase DNA directed eta, polymerase, DNA, kappa, type 2, ubiquitin specific peptidase 2
118427-55-7
> 98%
Solid
494.1 Da
C27H33ClNNaO2S
4519262
Synthetic
MW 494.1 Da, Purity >98%. Potent 5-lipoxygenase activating protein inhibitor (FLAP) (IC50 = 44 nM). Inhibits leukotriene biosynthesis (IC50 = 2.5 nM) in vitro and tumor activity in vivo. Displays PPARα antagonist activity. Orally active in vivo.
Alternative names=(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, 1,8-cineole 2-exo-monooxygenase, 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase, 3-oxoacyl-[acyl-carrier-protein] reductase, 3-oxoacyl-[acyl-carrier-protein] synthase, 41 kDa ubiquitin-specific protease, 5-LO, 5-LOX, 5-lipoxygenase, 5LPG, ALOX 5, Albendazole monooxygenase, Albendazole sulfoxidase, Arachidonate 5-lipoxygenase, Arachidonic acid 5 lipoxygenase, BDPLT14, BLM_HUMAN, BS, Bloom syndrome, Bloom syndrome RecQ helicase like, Bloom syndrome protein, CAMP GEFI, CGEF 1, CP2C9_HUMAN, CP33, CP34, CP3A4_HUMAN, CPC9, CYP2C, CYP2C10, CYP3, CYP3A, CYP3A3, CYP3A4, CYP5, CYP5A1, CYPIIC9, CYPIIIA3, CYPIIIA4, Cell cycle regulated protein kinase, Cytochrome P-450MP, Cytochrome P450 2C9, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 5A1, Cytochrome P450 HLp, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 NF-25, Cytochrome P450 PB-1, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450, family 2, subfamily C, polypeptide 9, Cytochrome P450, family 5, subfamily A, polypeptide 1, Cytochrome P450-PCN1, Cytosolic NADP-isocitrate dehydrogenase, DINB protein, DINB1, DINP, DKFZp686C2056, DNA damage inducible protein b, DNA directed DNA polymerase beta, DNA helicase, DNA helicase RecQ like type 2, DNA helicase, RecQ like type 3, DNA pol beta, DNA polymerase beta, DNA polymerase beta subunit, DNA polymerase eta, DNA polymerase iota, DNA polymerase kappa, DNA replication inhibitor, DPOLB_HUMAN, Deubiquitinating enzyme 2, DinB homolog 1 (E. coli), EPA1, EPAC, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ESRL 1, ESRR A, Enoyl-[acyl-carrier-protein] reductase, Epac 1, Epididymis luminal protein 216, Epididymis secretory protein Li 26, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen-related receptor alpha, Estrra, Eta 2, Exchange factor directly activated by cAMP 1, Exchange protein directly activated by cAMP 1, Exonuclease WRN, FASN, FAS_HUMAN, FLJ16395, FLJ21978, FLJ52771, Fatty acid synthase, GEMI_HUMAN, GHOSAL, GLP-1 receptor, GLP1R_HUMAN, GMNN, Geminin, Geminin DNA replication inhibitor, Glucagon-like peptide 1 receptor, Glucocorticoid inducible P450, HEL-216, HEL-S-26, HGNC 12791, HLP, ICDH, IDCD, IDH, IDH1, IDHC_HUMAN, IDP, IDPC, Isocitrate dehydrogenase (NADP(+)) 1 cytosolic, Isocitrate dehydrogenase 1 (NADP+) soluble, Isocitrate dehydrogenase [NADP] cytoplasmic, LOG 5, LOX5_HUMAN, Leukotriene A4 synthase, MGC125976, MGC126616, MGC126680, MGC131618, MGC131620, MGC138331, MGC14367, MGC149605, MGC15706, MGC163204, MGC21410, MGC88320, Microsomal monooxygenase, NADP dependent isocitrate dehydrogenase cytosolic, NADP dependent isocitrate dehydrogenase peroxisomal, NADP(+)-specific ICDH, NF 25, NR3B1, Nifedipine oxidase, Nuclear receptor subfamily 3 group B member 1, OA 519, OTTHUMP00000016340, OTTHUMP00000020135, OTTHUMP00000039393, OTTHUMP00000225301, Oleoyl-[acyl-carrier-protein] hydrolase, Oxalosuccinate decarboxylase, P450 III steroid inducible, P450 MP, P450 PB 1, P450 PCN1, P450, family III, P450C3, P450IIC9, PICD, PLK, PLK1_HUMAN, POLH_HUMAN, POLI_HUMAN, POLK_HUMAN, POLQ, Platelet cytochrome P450 subfamily V, Pol B, Pol beta, Polo-like kinase 1, Polymerase (DNA directed) beta, Polymerase (DNA directed) iota, Polymerase (DNA directed) kappa, Quinine 3-monooxygenase, RAD 30B, RAD30, RAD30 homolog A, RAD30 homolog B, RAD30, S. cerevisiae, homolog of, RAD30A, RAD3OB, RAP guanine nucleotide exchange factor, RAP guanine nucleotide exchange factor 3, RAPGEF3, RECQ 2, RECQ like, RECQL 2, RECQL 3, RP3 369A17.3, Rap guanine nucleotide exchange factor (GEF) 3, Rap1 guanine nucleotide exchange factor directly activated by cAMP, RecQ protein-like 2, RecQ protein-like 3, RecQ-like type 2, RecQ-like type 3, RecQ3, S-mephenytoin 4-hydroxylase, SDR27X1, STPK 13, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase PLK1, Short chain dehydrogenase/reductase family 27X member 1, Steroid hormone receptor ERR1, THAS_HUMAN, TS, TXA synthase, TXAS, TXS, Taurochenodeoxycholate 6-alpha-hydroxylase, Tbxas1, Thromboxane A synthase 1, Thromboxane A synthase 1 (platelet), Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A), Thromboxane A synthase 1 platelet cytochrome P450 subfamily V, Thromboxane-A synthase, UBP-t, UBP2_HUMAN, UBP41, USP9, Ubiquitin carboxyl-terminal hydrolase 2, Ubiquitin specific protease 12, Ubiquitin specific protease, 41kD, Ubiquitin thioesterase 2, Ubiquitin thiolesterase 2, Ubiquitin-specific protease 9, Ubiquitin-specific-processing protease 2, Ubiquitin-specific-processing protease testis, WRN_HUMAN, Werner syndrome ATP-dependent helicase, Werner syndrome helicase, Werner syndrome protein, Werner syndrome, RecQ helicase like, XP V, Xenobiotic monooxygenase, Xeroderma pigmentosum variant type protein, [Acyl-carrier-protein] S acetyltransferase, [Acyl-carrier-protein] S malonyltransferase, arachidonic 5-lipoxygenase alpha-10 isoform, arachidonic 5-lipoxygenase delta-10-13 isoform, arachidonic 5-lipoxygenase delta-13 isoform, arachidonic 5-lipoxygenase delta-p10 isoform, bcm910, cAMP regulated guanine nucleotide exchange factor I, cytochrome P-450 S-mephenytoin 4-hydroxylase, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, estrogen receptor related receptor alpha, flavoprotein-linked monooxygenase, hERR1, polymerase DNA directed eta, polymerase, DNA, kappa, type 2, ubiquitin specific peptidase 2
118427-55-7
> 98%
Solid
494.1 Da
C27H33ClNNaO2S
4519262
Synthetic
MK886 sodium
Potent 5-lipoxygenase activating protein inhibitor (FLAP) (IC50 = 44 nM). Inhibits leukotriene biosynthesis (IC50 = 2.5 nM) in vitro and tumor activity in vivo. Displays PPARα antagonist activity. Orally active in vivo.
CC(C)C1=CC2=C(C=C1)N(C(=C2SC(C)(C)C)CC(C)(C)C(=O)[O-])CC3=CC=C(C=C3)Cl.[Na+]
InChI=1S/C27H34ClNO2S.Na/c1-17(2)19-10-13-22-21(14-19)24(32-26(3,4)5)23(15-27(6,7)25(30)31)29(22)16-18-8-11-20(28)12-9-18;/h8-14,17H,15-16H2,1-7H3,(H,30,31);/q;+1/p-1
CBNCIYNCWVGEKJ-UHFFFAOYSA-M
sodium;3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoate
Ambient - Can Ship with Ice
Ambient
The product can be stored for up to 12 months
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