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MW 494.1 Da, Purity >98%. Potent 5-lipoxygenase activating protein inhibitor (FLAP) (IC50 = 44 nM). Inhibits leukotriene biosynthesis (IC50 = 2.5 nM) in vitro and tumor activity in vivo. Displays PPARα antagonist activity. Orally active in vivo.

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CAS number

118427-55-7

Purity

> 98%

Form

Solid

Molecular weight

494.1 Da

Molecular formula

C27H33ClNNaO2S

PubChem identifier

4519262

Nature

Synthetic

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MW 494.1 Da, Purity >98%. Potent 5-lipoxygenase activating protein inhibitor (FLAP) (IC50 = 44 nM). Inhibits leukotriene biosynthesis (IC50 = 2.5 nM) in vitro and tumor activity in vivo. Displays PPARα antagonist activity. Orally active in vivo.

Key facts

Purity

> 98%

PubChem identifier

4519262

Biochemical name

MK886 sodium

Biological description

Potent 5-lipoxygenase activating protein inhibitor (FLAP) (IC50 = 44 nM). Inhibits leukotriene biosynthesis (IC50 = 2.5 nM) in vitro and tumor activity in vivo. Displays PPARα antagonist activity. Orally active in vivo.

Canonical SMILES

CC(C)C1=CC2=C(C=C1)N(C(=C2SC(C)(C)C)CC(C)(C)C(=O)[O-])CC3=CC=C(C=C3)Cl.[Na+]

InChI

InChI=1S/C27H34ClNO2S.Na/c1-17(2)19-10-13-22-21(14-19)24(32-26(3,4)5)23(15-27(6,7)25(30)31)29(22)16-18-8-11-20(28)12-9-18;/h8-14,17H,15-16H2,1-7H3,(H,30,31);/q;+1/p-1

InChIKey

CBNCIYNCWVGEKJ-UHFFFAOYSA-M

IUPAC name

sodium;3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoate

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

Ambient

Storage information

The product can be stored for up to 12 months

Product promise

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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