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MW 477.4 Da, Purity >=98%. ML-162 is a GPX4 (glutathione peroxidase 4) inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).

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Publications

Key facts

CAS number

1035072-16-2

Purity

>= 98%

Form

Solid

Molecular weight

477.4 Da

Molecular formula

C23H22Cl2N2O3S

PubChem identifier

3689413

Nature

Synthetic

Target data

Alternative names

MGC61518, PI3-kinase type 3, PI3K type 3, PK3C3_HUMAN, Phosphatidylinositol 3 kinase class 3, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 3-kinase p100 subunit, Phosphoinositide-3-kinase class 3, Pik3c3, PtdIns-3-kinase type 3, hVps34

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MW 477.4 Da, Purity >=98%. ML-162 is a GPX4 (glutathione peroxidase 4) inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).

Key facts

Purity

>= 98%

PubChem identifier

3689413

Solubility

Soluble in DMSO to >25 mM.

Biochemical name

2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide

Biological description

ML-162 is a GPX4 (glutathione peroxidase 4) inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).

Canonical SMILES

COC1=C(C=C(C=C1)N(C(C2=CC=CS2)C(=O)NCCC3=CC=CC=C3)C(=O)CCl)Cl

InChI

InChI=1S/C23H22Cl2N2O3S/c1-30-19-10-9-17(14-18(19)25)27(21(28)15-24)22(20-8-5-13-31-20)23(29)26-12-11-16-6-3-2-4-7-16/h2-10,13-14,22H,11-12,15H2,1H3,(H,26,29)

InChIKey

UNVKYJSNMVDZJE-UHFFFAOYSA-N

IUPAC name

2-(3-chloro-N-(2-chloroacetyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store in the dark, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

Notes

This product is manufactured by BioVision, an Abcam company and was previously called B2304 ML-162. B2304-5 is the same size as the 5 mg size of ab286999.

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