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MW 477.4 Da, Purity >=98%. ML-162 is a GPX4 (glutathione peroxidase 4) inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).

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Key facts

CAS number
1035072-16-2
Purity
>= 98%
Form
Solid
Molecular weight
477.4 Da
Molecular formula
C23H22Cl2N2O3S
PubChem identifier
3689413
Nature
Synthetic

Target data

Alternative names

MGC61518, PI3-kinase type 3, PI3K type 3, PK3C3_HUMAN, Phosphatidylinositol 3 kinase class 3, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 3-kinase p100 subunit, Phosphoinositide-3-kinase class 3, Pik3c3, PtdIns-3-kinase type 3, hVps34

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MW 477.4 Da, Purity >=98%. ML-162 is a GPX4 (glutathione peroxidase 4) inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).

Key facts

Purity
>= 98%
PubChem identifier
3689413
Solubility

Soluble in DMSO to >25 mM.

Biochemical name
2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide
Biological description

ML-162 is a GPX4 (glutathione peroxidase 4) inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).

Canonical SMILES
COC1=C(C=C(C=C1)N(C(C2=CC=CS2)C(=O)NCCC3=CC=CC=C3)C(=O)CCl)Cl
InChI
InChI=1S/C23H22Cl2N2O3S/c1-30-19-10-9-17(14-18(19)25)27(21(28)15-24)22(20-8-5-13-31-20)23(29)26-12-11-16-6-3-2-4-7-16/h2-10,13-14,22H,11-12,15H2,1H3,(H,26,29)
InChIKey
UNVKYJSNMVDZJE-UHFFFAOYSA-N
IUPAC name
2-(3-chloro-N-(2-chloroacetyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

Notes

This product is manufactured by BioVision, an Abcam company and was previously called B2304 ML-162. B2304-5 is the same size as the 5 mg size of ab286999.

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