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AB286999

ML-162

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MW 477.4 Da, Purity >98%. ML-162 is a GPX4 (glutathione peroxidase 4) inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).

Key facts

CAS number

1035072-16-2

Purity

>98%

Form

Solid

form

Molecular weight

477.4 Da

Molecular formula

C<sub>2</sub><sub>3</sub>H<sub>2</sub><sub>2</sub>Cl<sub>2</sub>N<sub>2</sub>O<sub>3</sub>S

PubChem

3689413

Nature

Synthetic

Solubility

Soluble in DMSO to >25 mM

Biochemical name

2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide

Biological description

ML-162 is a GPX4 (glutathione peroxidase 4) inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).

Canonical smiles

COC1=C(C=C(C=C1)N(C(C2=CC=CS2)C(=O)NCCC3=CC=CC=C3)C(=O)CCl)Cl

InChi

InChI=1S/C23H22Cl2N2O3S/c1-30-19-10-9-17(14-18(19)25)27(21(28)15-24)22(20-8-5-13-31-20)23(29)26-12-11-16-6-3-2-4-7-16/h2-10,13-14,22H,11-12,15H2,1H3,(H,26,29)

InChiKey

UNVKYJSNMVDZJE-UHFFFAOYSA-N

IUPAC Name

2-(3-chloro-N-(2-chloroacetyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide

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Complementary Products

Biochemicals

AB141254

DBeQ, p97 ATPase inhibitor

Chemical Structure - DBeQ, p97 ATPase inhibitor (AB141254)

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Assay Kits

AB83463

Thioredoxin Reductase Assay Kit (Colorimetric)

Functional Studies - Thioredoxin Reductase Assay Kit (Colorimetric) (AB83463)

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Primary Antibodies

AB27642

Anti-Malondialdehyde antibody

Western blot - Anti-Malondialdehyde antibody (AB27642)

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Assay Kits

AB239709

GSH+GSSG / GSH Assay Kit (Colorimetric)

Functional Studies - GSH+GSSG / GSH Assay Kit (Colorimetric) (AB239709)

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called B2304 ML-162. B2304-5 is the same size as the 5 mg size of ab286999.
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
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Product protocols

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Product promise

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