JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB269883

ML 204, TRPC4 blocker

Be the first to review this product! Submit a review

|

(0 Publication)

MW 226.32 Da. Selective TRPC4 channel blocker (IC50 = 0.96 (fluorescence assay) - 2.6 μM (electrophysiological assay)). Selective versus TRPC6 (19-fold) and TRPC5 (9-fold). Essentially inactive at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM.
1 Images
Chemical Structure - ML 204, TRPC4 blocker (AB269883)
  • Chemical Structure

Lab

Chemical Structure - ML 204, TRPC4 blocker (AB269883)

Chemical structure of ML 204, TRPC4 blocker, 5465-86-1

Key facts

CAS number

5465-86-1

Form

Solid

form

Molecular weight

226.32 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>8</sub>N<sub>2</sub>

PubChem

230710

Nature

Synthetic

Solubility

Soluble in DMSO to 75 mM

Biochemical name

4-Methyl-2-(piperidin-1-yl)quinoline

Biological description

Selective TRPC4 channel blocker (IC50 = 0.96 (fluorescence assay) - 2.6 μM (electrophysiological assay)). Selective versus TRPC6 (19-fold) and TRPC5 (9-fold). Essentially inactive at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM.

Canonical smiles

CC1=CC(=NC2=CC=CC=C12)N3CCCCC3

InChi

InChI=1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14/h3-4,7-8,11H,2,5-6,9-10H2,1H3

InChiKey

USYRQXDHKXGTCK-UHFFFAOYSA-N

IUPAC Name

4-methyl-2-piperidin-1-ylquinoline

style
left-column

Complementary Products

Biochemicals

AB120728

trans-Retinoic acid, Stem cell differentiator

Immunocytochemistry/ Immunofluorescence - trans-Retinoic acid, Stem cell differentiator (AB120728)

  • 0
  • 0
Primary Antibodies

AB153810

Anti-TRPC4AP antibody

Western blot - Anti-TRPC4AP antibody (AB153810)

  • 0
  • 0
Biochemicals

AB120078

nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist

Chemical Structure - nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist (AB120078)

  • 0
  • 0
Biochemicals

AB141115

scyllo-Inositol, Endogenous inositol isomer

Chemical Structure - scyllo-Inositol, Endogenous inositol isomer (AB141115)

  • 0
  • 0
style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

|

Refer to SDS for further information.

style
left-column
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com