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AB146175

ML-324, JMJD2 inhibitor

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MW 349.4 Da. Potent, cell-permeable JMJD2 inhibitor (IC50 = 920 nM). Shows antiviral effects (IC50 = 10 μM), HSV-1 immediate early gene expression). Reversibly blocks human cytomegalovirus infection in vivo. .
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Chemical Structure - ML-324, JMJD2 inhibitor (AB146175)
  • Chemical Structure

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Chemical Structure - ML-324, JMJD2 inhibitor (AB146175)

2D chemical structure image of ab146175, ML-324, JMJD2 inhibitor

Key facts

CAS number

1222800-79-4

Form

Solid

form

Molecular weight

349.4 Da

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>2</sub><sub>3</sub>N<sub>3</sub>O<sub>2</sub>

PubChem

44143209

Nature

Synthetic

Solubility

Soluble in ethanol to 10 mM

Soluble in DMSO to 50 mM

Biochemical name

N-(3-(Dimethylamino)propyl)-4-(8-hydroxyquinolin-6-yl)benzamide

Biological description

Potent, cell-permeable JMJD2 inhibitor (IC50 = 920 nM). Shows antiviral effects (IC50 = 10 μM), HSV-1 immediate early gene expression). Reversibly blocks human cytomegalovirus infection in vivo.

Canonical smiles

CN(C)CCCNC(=O)C1=CC=C(C=C1)C2=CC(=C3C(=C2)C=CC=N3)O

InChi

InChI=1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26)

InChiKey

QDBVSOZTVKXUES-UHFFFAOYSA-N

IUPAC Name

N-[3-(dimethylamino)propyl]-4-(8-hydroxyquinolin-6-yl)benzamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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