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MW 511.6 Da, Purity >=98%. A potent and selective Nrf2 inhibitor (Nrf2; IC50 = 1.9 μM). ML-385 blocks Nrf2 downstream target gene expression. ML-385 displays specificity and selectivity for NSCLC cells with KEAP1 mutation, which leads to gain of Nrf2 function.

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Publications

Key facts

CAS number

846557-71-9

Purity

>= 98%

Form

Solid

Molecular weight

511.6 Da

Molecular formula

C29H25N3O4S

PubChem identifier

1383822

Nature

Synthetic

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MW 511.6 Da, Purity >=98%. A potent and selective Nrf2 inhibitor (Nrf2; IC50 = 1.9 μM). ML-385 blocks Nrf2 downstream target gene expression. ML-385 displays specificity and selectivity for NSCLC cells with KEAP1 mutation, which leads to gain of Nrf2 function.

Key facts

Purity

>= 98%

PubChem identifier

1383822

Solubility

>25 mg/ml in DMSO.

Biochemical name

2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide

Biological description

A potent and selective Nrf2 inhibitor (Nrf2; IC50 = 1.9 μM). ML-385 blocks Nrf2 downstream target gene expression. ML-385 displays specificity and selectivity for NSCLC cells with KEAP1 mutation, which leads to gain of Nrf2 function.

Canonical SMILES

CC1=CC=CC=C1C(=O)N2CCC3=C2C=CC(=C3)C4=C(SC(=N4)NC(=O)CC5=CC6=C(C=C5)OCO6)C

InChI

InChI=1S/C29H25N3O4S/c1-17-5-3-4-6-22(17)28(34)32-12-11-20-15-21(8-9-23(20)32)27-18(2)37-29(31-27)30-26(33)14-19-7-10-24-25(13-19)36-16-35-24/h3-10,13,15H,11-12,14,16H2,1-2H3,(H,30,31,33)

InChIKey

LINHYWKZVCNAMQ-UHFFFAOYSA-N

IUPAC name

2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

It is important to note that this product is reported to be light sensitive, Store in the dark

Notes

This product is manufactured by BioVision, an Abcam company and was previously called B2605 ML-385. B2605-25 is the same size as the 25 mg size of ab287109.

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