MW 511.6 Da, Purity >=98%. A potent and selective Nrf2 inhibitor (Nrf2; IC50 = 1.9 μM). ML-385 blocks Nrf2 downstream target gene expression. ML-385 displays specificity and selectivity for NSCLC cells with KEAP1 mutation, which leads to gain of Nrf2 function.
846557-71-9
>= 98%
Solid
511.6 Da
C29H25N3O4S
1383822
Synthetic
MW 511.6 Da, Purity >=98%. A potent and selective Nrf2 inhibitor (Nrf2; IC50 = 1.9 μM). ML-385 blocks Nrf2 downstream target gene expression. ML-385 displays specificity and selectivity for NSCLC cells with KEAP1 mutation, which leads to gain of Nrf2 function.
846557-71-9
>= 98%
Solid
511.6 Da
C29H25N3O4S
1383822
Synthetic
>25 mg/ml in DMSO.
2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide
A potent and selective Nrf2 inhibitor (Nrf2; IC50 = 1.9 μM). ML-385 blocks Nrf2 downstream target gene expression. ML-385 displays specificity and selectivity for NSCLC cells with KEAP1 mutation, which leads to gain of Nrf2 function.
CC1=CC=CC=C1C(=O)N2CCC3=C2C=CC(=C3)C4=C(SC(=N4)NC(=O)CC5=CC6=C(C=C5)OCO6)C
InChI=1S/C29H25N3O4S/c1-17-5-3-4-6-22(17)28(34)32-12-11-20-15-21(8-9-23(20)32)27-18(2)37-29(31-27)30-26(33)14-19-7-10-24-25(13-19)36-16-35-24/h3-10,13,15H,11-12,14,16H2,1-2H3,(H,30,31,33)
LINHYWKZVCNAMQ-UHFFFAOYSA-N
2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide
Blue Ice
-20°C
-20°C
It is important to note that this product is reported to be light sensitive, Store in the dark
This product is manufactured by BioVision, an Abcam company and was previously called B2605 ML-385. B2605-25 is the same size as the 25 mg size of ab287109.
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