ML-SA1, TRPML agonist

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRPC4 also known as Transient Receptor Potential Cation Channel Subfamily C Member 4 plays an important mechanical role as a non-selective cation channel that conducts calcium and sodium ions into cells. This protein has a molecular weight of approximately 100 kDa. TRPC4 is highly expressed in various tissues including the brain heart lung and kidney. Its presence in these tissues suggests an important role in multiple physiological processes.

Biological function summary

TRPC4 influences cellular calcium signaling impacting a variety of physiological responses such as vasodilation and neurotransmission. TRPC4 can form both homo- and heteromeric complexes often associating with other TRPC family members. Through these complexes TRPC4 contributes to cellular responses to neurotransmitters and other signaling molecules indicating its role in a wide range of cellular functions.

Pathways

TRPC4 participates in the phospholipase C (PLC) signaling pathway which regulates important cellular functions such as cell proliferation and differentiation. TRPC4 is related to G-protein coupled receptors (GPCRs) within this pathway facilitating the relay of extracellular signals through PLC activation and subsequent calcium influx. Additionally TRPC4 interacts with proteins like calmodulin which modulates its activity and impacts calcium-related signaling pathways.

TRPC4's dysregulation associates with cardiovascular diseases and anxiety disorders. The aberrant calcium entry through TRPC4 channels can lead to pathological conditions such as hypertension and heart failure. During stress responses the interaction between TRPC4 and CRHR2 the corticotropin-releasing hormone receptor 2 may affect anxiety-related behaviors hinting at TRPC4’s involvement in psychiatric disorders. By influencing these pathways TRPC4 emerges as a potential therapeutic target for managing such conditions.