ML130, NOD1 inhibitor

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Interleukin-8 (IL-8) also known as CXCL8 is a chemokine with a mass of approximately 8 kDa. It plays a role in the immune response by attracting neutrophils to sites of inflammation. IL-8 is expressed in various cells including macrophages epithelial cells and airway smooth muscle cells. Another related target is NOD1 (nucleotide-binding oligomerization domain-containing protein 1) which senses bacterial peptidoglycans and helps trigger immune reactions.

Biological function summary

This family of proteins functions in the immune system to mediate inflammatory responses. IL-8 initiates the movement and activation of neutrophils while NOD1 acts as an intracellular pattern recognition receptor. Together they form part of a complex network that protects the body from infections by activating immune cells and promoting the production of cytokines.

Pathways

IL-8 and NOD1 participate in important signaling pathways that regulate immune response and inflammation. IL-8 is involved in the chemokine signaling pathway influencing other proteins like CXCR1 and CXCR2 receptors on leukocytes. NOD1 participates in the NF-κB pathway which involves proteins like RIP2 kinase playing a role in inflammatory signal transduction.

IL-8 and NOD1 have significant implications in various immune-related conditions. For IL-8 its overexpression often relates to chronic inflammatory diseases like rheumatoid arthritis. NOD1 is associated with inflammatory bowel disease where its activity contributes to intestinal inflammation. In these contexts IL-8 works alongside CXCR receptors while NOD1 interacts with RIP2 kinase to influence disease progression.