AB120848

ML7, myosin light chain kinase inhibitor

Name: ML7, myosin light chain kinase inhibitor (CAS 109376-83-2) | Abcam
Brand: Abcam Limited
SKU: AB120848
Price: 110 USD
Availability: InStock

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(10 Publications)

MW 452.7 Da, Purity >99%. Potent and selective myosin light chain kinase inhibitor (MLCK) (K_i = 300 nM). Also inhibits PKA and PKC (K_i values are 21 and 42 μM, respectively). Cell-permeable. Inhibits tumor cell growth.

1 Images

Chemical Structure - ML7, myosin light chain kinase inhibitor (AB120848)

Chemical Structure

Lab

Chemical Structure - ML7, myosin light chain kinase inhibitor (AB120848)

2D chemical structure image of ab120848, ML7, myosin light chain kinase inhibitor

Key facts

CAS number

109376-83-2

Purity

>99%

Form

Solid

form

Molecular weight

452.7 Da

Molecular formula

C15H18ClIN2O2S

PubChem

9803932

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

1-((5-Iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride

Biological description

Potent and selective myosin light chain kinase inhibitor (MLCK) (K_i = 300 nM). Also inhibits PKA and PKC (K_i values are 21 and 42 μM, respectively). Cell-permeable. Inhibits tumor cell growth.

Canonical smiles

C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CC=C3I.Cl

InChi

InChI=1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H

InChiKey

KDDALCDYHZIZMH-UHFFFAOYSA-N

IUPAC Name

1-(5-iodonaphthalen-1-yl)sulfonyl-1,4-diazepane;hydrochloride

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions|The product can be stored for up to 12 months

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Product protocols

Visit the General protocols
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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

Journal of the Association for Research in Otolaryngology : JARO 26:225-238 PubMed40240732

2025

Influence of Myosin Regulatory Light Chain and Myosin Light Chain Kinase on the Physiological Function of Inner Ear Hair Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ryohei Oya,Kwang Min Woo,Brian Fabella,R G Alonso,Paloma Bravo,A J Hudspeth

Journal of cell science 137: PubMed38345101

2024

Culture substrate stiffness impacts human myoblast contractility-dependent proliferation and nuclear envelope wrinkling.

Applications

Unspecified application

Species

Unspecified reactive species

Jo Nguyen,Lu Wang,Wen Lei,Yechen Hu,Nitya Gulati,Carolina Chavez-Madero,Henry Ahn,Howard J Ginsberg,Roman Krawetz,Matthias Brandt,Timo Betz,Penney M Gilbert

Development (Cambridge, England) 149: PubMed35420656

2022

Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaorei Sai,Yayoi Ikawa,Hiromi Nishimura,Katsutoshi Mizuno,Eriko Kajikawa,Takanobu A Katoh,Toshiya Kimura,Hidetaka Shiratori,Katsuyoshi Takaoka,Hiroshi Hamada,Katsura Minegishi

Journal of neuroinflammation 18:234 PubMed34654444

2021

Macrophage-specific RhoA knockout delays Wallerian degeneration after peripheral nerve injury in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jiawei Xu,Jinkun Wen,Lanya Fu,Liqiang Liao,Ying Zou,Jiaqi Zhang,Junyao Deng,Haowen Zhang,Jingmin Liu,Xianghai Wang,Daming Zuo,Jiasong Guo

Journal of the Association for Research in Otolaryngology : JARO 22:425-441 PubMed33877471

2021

Phosphorylation of MYL12 by Myosin Light Chain Kinase Regulates Cellular Shape Changes in Cochlear Hair Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ryohei Oya,Osamu Tsukamoto,Takashi Sato,Hisakazu Kato,Ken Matsuoka,Kazuo Oshima,Takefumi Kamakura,Yumi Ohta,Takao Imai,Seiji Takashima,Hidenori Inohara

Genes to cells : devoted to molecular & cellular mechanisms 24:731-745 PubMed31554018

2019

Ciliogenesis-coupled accumulation of IFT-B proteins in a novel cytoplasmic compartment.

Applications

Unspecified application

Species

Unspecified reactive species

Lynda Lamri,Wang Kyaw Twan,Takanobu A Katoh,Yanick Botilde,Katsuyoshi Takaoka,Yayoi Ikawa,Hiromi Nishimura,Akemi Fukumoto,Katsura Minegishi,Katsutoshi Mizuno,Hiroshi Hamada

Journal of cellular and molecular medicine 23:3696-3710 PubMed30907506

2019

MicroRNA-92a promotes vascular smooth muscle cell proliferation and migration through the ROCK/MLCK signalling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jingyu Wang,Chenxu Zhang,Cai Li,Dandan Zhao,Shuyao Li,Le Ma,Ying Cui,Xiaoqing Wei,Ying Zhao,Ying Gao

Soft matter 15:1721-1729 PubMed30657157

2019

Combined atomic force microscopy (AFM) and traction force microscopy (TFM) reveals a correlation between viscoelastic material properties and contractile prestress of living cells.

Applications

Unspecified application

Species

Unspecified reactive species

Nicolas Schierbaum,Johannes Rheinlaender,Tilman E Schäffer

The Journal of cell biology 217:4314-4330 PubMed30389720

2018

Keratin 6 regulates collective keratinocyte migration by altering cell-cell and cell-matrix adhesion.

Applications

Unspecified application

Species

Unspecified reactive species

Fengrong Wang,Song Chen,Hans B Liu,Carole A Parent,Pierre A Coulombe

Biomedical reports 8:283-288 PubMed29599980

2018

Gender differences in the regulation of MLC phosphorylation and smooth muscle contraction in rat stomach.

Applications

Unspecified application

Species

Unspecified reactive species

Othman A Al-Shboul,Ahmed N Al-Dwairi,Mohammad A Alqudah,Ayman G Mustafa

View all publications

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ML7, myosin light chain kinase inhibitor

Chemical Structure - ML7, myosin light chain kinase inhibitor (AB120848)

Key facts

CAS number

Purity

Form

Molecular weight

Molecular formula

PubChem

Nature

Solubility

Biochemical name

Biological description

Canonical smiles

InChi

InChiKey

IUPAC Name

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Publications (10)

Complementary Products

Secondary Antibodies

Primary Antibodies

Biochemicals

Biochemicals

Product promise