MW 452.7 Da, Purity >99%. Potent and selective myosin light chain kinase inhibitor (MLCK) (Ki = 300 nM). Also inhibits PKA and PKC (Ki values are 21 and 42 μM, respectively). Cell-permeable. Inhibits tumor cell growth.
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- Development (Cambridge, England) 149:2022Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaorei Sai,Yayoi Ikawa,Hiromi Nishimura,Katsutoshi Mizuno,Eriko Kajikawa,Takanobu A Katoh,Toshiya Kimura,Hidetaka Shiratori,Katsuyoshi Takaoka,Hiroshi Hamada,Katsura MinegishiPubMed 35420656
- Journal of neuroinflammation 18:2342021Macrophage-specific RhoA knockout delays Wallerian degeneration after peripheral nerve injury in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJiawei Xu,Jinkun Wen,Lanya Fu,Liqiang Liao,Ying Zou,Jiaqi Zhang,Junyao Deng,Haowen Zhang,Jingmin Liu,Xianghai Wang,Daming Zuo,Jiasong GuoPubMed 34654444
- Journal of the Association for Research in Otolaryngology : JARO 22:425-4412021Phosphorylation of MYL12 by Myosin Light Chain Kinase Regulates Cellular Shape Changes in Cochlear Hair Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRyohei Oya,Osamu Tsukamoto,Takashi Sato,Hisakazu Kato,Ken Matsuoka,Kazuo Oshima,Takefumi Kamakura,Yumi Ohta,Takao Imai,Seiji Takashima,Hidenori InoharaPubMed 33877471
- Genes to cells : devoted to molecular & cellular mechanisms 24:731-7452019Ciliogenesis-coupled accumulation of IFT-B proteins in a novel cytoplasmic compartment.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLynda Lamri,Wang Kyaw Twan,Takanobu A Katoh,Yanick Botilde,Katsuyoshi Takaoka,Yayoi Ikawa,Hiromi Nishimura,Akemi Fukumoto,Katsura Minegishi,Katsutoshi Mizuno,Hiroshi HamadaPubMed 31554018
- Journal of cellular and molecular medicine 23:3696-37102019MicroRNA-92a promotes vascular smooth muscle cell proliferation and migration through the ROCK/MLCK signalling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJingyu Wang et. al.PubMed 30907506
- Soft matter 15:1721-17292019Combined atomic force microscopy (AFM) and traction force microscopy (TFM) reveals a correlation between viscoelastic material properties and contractile prestress of living cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNicolas Schierbaum,Johannes Rheinlaender,Tilman E SchäfferPubMed 30657157
- The Journal of cell biology 217:4314-43302018Keratin 6 regulates collective keratinocyte migration by altering cell-cell and cell-matrix adhesion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFengrong Wang,Song Chen,Hans B Liu,Carole A Parent,Pierre A CoulombePubMed 30389720
- Biomedical reports 8:283-2882018Gender differences in the regulation of MLC phosphorylation and smooth muscle contraction in rat stomach.Applications:Unspecified applicationReactive species:Unspecified reactive speciesOthman A Al-Shboul et. al.PubMed 29599980
Key facts
- CAS number
- 109376-83-2
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 452.7 Da
- Molecular formula
- C15H18ClIN2O2S
- PubChem identifier
- 9803932
- Nature
- Synthetic
Target data
Recommended products
MW 452.7 Da, Purity >99%. Potent and selective myosin light chain kinase inhibitor (MLCK) (Ki = 300 nM). Also inhibits PKA and PKC (Ki values are 21 and 42 μM, respectively). Cell-permeable. Inhibits tumor cell growth.
Key facts
- CAS number
- 109376-83-2
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 452.7 Da
- Molecular formula
- C15H18ClIN2O2S
- PubChem identifier
- 9803932
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biochemical name
- 1-((5-Iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride
- Biological description
Potent and selective myosin light chain kinase inhibitor (MLCK) (Ki = 300 nM). Also inhibits PKA and PKC (Ki values are 21 and 42 μM, respectively). Cell-permeable. Inhibits tumor cell growth.
- Canonical SMILES
- C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CC=C3I.Cl
- InChI
- InChI=1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
- InChIKey
- KDDALCDYHZIZMH-UHFFFAOYSA-N
- IUPAC name
- 1-(5-iodonaphthalen-1-yl)sulfonyl-1,4-diazepane;hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - ML7, myosin light chain kinase inhibitor (ab120848)
2D chemical structure image of ab120848, ML7, myosin light chain kinase inhibitor
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