MW 511.6 Da, Purity >95%. MMP-9 inhibitor. Role in tumor cell migration, invasion and angiogenesis. Achieve your results faster with highly validated, pure and trusted compounds.
27 kDa interstitial collagenase, 82 kDa matrix metalloproteinase-9, 92 kDa gelatinase, 92 kDa type IV collagenase, CLG, CLG 3, CLG 4B, Collagenase 3, Collagenase Type 4 beta, Collagenase type IV 92 KD, EC 3.4.24.35, Fibroblast collagenase, GELB, Gelatinase 92 KD, Gelatinase B, Gelatinase beta, Interstitial collagenase, MANDP1, MANDP2, MMP13_HUMAN, MMP1_HUMAN, MMP9_HUMAN, Macrophage gelatinase, Matrix Metalloproteinase 9, Matrix metallopeptidase 1 (interstitial collagenase), Matrix metallopeptidase 13 (collagenase 3), Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), Matrix metalloprotease 1, Matrix metalloproteinase-1, Matrix metalloproteinase-13, OTTHUMP00000045866, Type V collagenase, collagenase, fibroblast, collagenase, interstitial
MW 511.6 Da, Purity >95%. MMP-9 inhibitor. Role in tumor cell migration, invasion and angiogenesis. Achieve your results faster with highly validated, pure and trusted compounds.
Soluble in DMSO to 10 mM.
MMP-9 inhibitor. Role in tumor cell migration, invasion and angiogenesis
This product is manufactured by BioVision, an Abcam company and was previously called 1981 MMP-9 Inhibitor. 1981-500 is the same size as the 500 μg size of ab142180.
The proteins MMP1 MMP9 and MMP13 belong to the matrix metalloproteinase (MMP) family and function mainly as enzymes that degrade various components of the extracellular matrix. MMP1 also known as collagenase-1 has a mass of approximately 54 kDa and primarily targets interstitial collagen. MMP9 known as gelatinase B is about 92 kDa and digests denatured collagen (gelatin) and elastin. MMP13 or collagenase-3 is around 60 kDa and degrades type II collagen among other substrates. These MMPs express in various tissues including skin cartilage and the immune system playing roles in tissue remodeling and repair.
These MMPs regulate extracellular matrix composition and influence cellular behaviors like migration and invasion. MMP1 MMP9 and MMP13 participate in normal developmental processes and the breakdown of extracellular matrix in pathological conditions. They form complexes with tissue inhibitors of metalloproteinases (TIMPs) that modulate their activities ensuring balanced matrix turnover. Their expression requires precise control because unregulated activity can lead to tissue damage.
MMP1 MMP9 and MMP13 integrate into complex networks like the collagen degradation and inflammation pathways. MMP9 is an important actor in the inflammatory response often upregulated by cytokines and serving a role in leukocyte migration facilitated by its interaction with integrins. The Wnt signaling pathway connects to MMP13 highlighting its involvement in cartilage metabolism and bone remodeling. These proteins interact with others in these pathways like interleukins and integrins to coordinate a broad range of physiological effects.
MMP dysregulation associates with conditions like arthritis and cancer. In arthritis MMP13 excessively degrades cartilage collagen contributing to joint destruction while interactions with cytokines amplify inflammation. In cancer MMP9 assists tumor invasion and metastasis through matrix degradation and works in conjunction with VEGF to promote angiogenesis. MMP9 inhibitors have been investigated for therapeutic use in cancer treatment due to these contributions. Understanding these mechanisms highlights the importance of MMP regulation and inhibition in disease contexts.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com