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AB120245

MMPIP, mGlu7 allosteric antagonist

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(3 Publications)

MW 333.3 Da, Purity >98%. Potent, selective allosteric antagonist at mGlu7 receptors. Inhibits agonist-induced intracellular calcium mobilisation and cAMP accumulation (IC50 values are 26 and 610 nM). Also displays intrinsic activity; increasing forskolin-induced cAMP accumulation in the absence of an agonist. Exhibits no significant activity at mGluR1, mGluR2, mGluR3, mGluR4, mGluR5, and mGluR8. Also available in Kit: mGlu antagonists (ab120322).

View Alternative Names

FLJ40498, GLUR, GPRC1G, GRM7_HUMAN, GluR-7, Glutamate receptor metabotropic 7, MGLU7, Metabotropic glutamate receptor 7, OTTHUMP00000206961, OTTHUMP00000214674, OTTHUMP00000214675, Smp_128940, mGluR7

1 Images
Chemical Structure - MMPIP, mGlu7 allosteric antagonist (AB120245)
  • Chemical Structure

Lab

Chemical Structure - MMPIP, mGlu7 allosteric antagonist (AB120245)

2D chemical structure image of ab120245, MMPIP, mGlu7 allosteric antagonist

Key facts

CAS number

479077-02-6

Purity

>98%

Form

Solid

form

Molecular weight

333.3 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>1</sub><sub>5</sub>N<sub>3</sub>O<sub>3</sub>

PubChem

9945530

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Biochemical name

Mmpip

Biological description

Potent, selective allosteric antagonist at mGlu7 receptors. Inhibits agonist-induced intracellular calcium mobilisation and cAMP accumulation (IC50 values are 26 and 610 nM). Also displays intrinsic activity; increasing forskolin-induced cAMP accumulation in the absence of an agonist. Exhibits no significant activity at mGluR1, mGluR2, mGluR3, mGluR4, mGluR5, and mGluR8. Also available in Kit: mGlu antagonists (ab120322)

Canonical smiles

CN1C(=CC2=C(C1=O)C(=NO2)C3=CC=NC=C3)C4=CC=C(C=C4)OC

InChi

InChI=1S/C19H15N3O3/c1-22-15(12-3-5-14(24-2)6-4-12)11-16-17(19(22)23)18(21-25-16)13-7-9-20-10-8-13/h3-11H,1-2H3

InChiKey

PDWYBOZNEVALOV-UHFFFAOYSA-N

IUPAC Name

6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-yl-[1,2]oxazolo[4,5-c]pyridin-4-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cellular neuroscience 9:345 PubMed26388733

2015

Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.

Applications

Unspecified application

Species

Unspecified reactive species

Luca Bragina,Tiziana Bonifacino,Silvia Bassi,Marco Milanese,Giambattista Bonanno,Fiorenzo Conti

Behavioural brain research 253:9-16 PubMed23827202

2013

Effects of group II and III metabotropic glutamate receptor ligands on conditioned taste aversion learning.

Applications

Unspecified application

Species

Unspecified reactive species

D Klakotskaia,A K Ramsey,S W Fowler,P Serfozo,A Simonyi,T R Schachtman

Addiction biology 17:235-47 PubMed21392179

2011

Pharmacological modulation of mGluR7 with AMN082 and MMPIP exerts specific influences on alcohol consumption and preference in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Amine Bahi,Katharina Fizia,Monika Dietz,Fabrizio Gasparini,Peter J Flor
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