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AB145046

MMPSI, Caspase-3/7 Inhibitor I, caspase 3 and 7 inhibitor

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(4 Publications )

MW 324.35 Da, Purity >98%. Selective caspase 3 and 7 inhibitor (IC50 = 1.7 μM, caspase-3). Reduces ischemic-induced apoptosis (IC50 = 0.5 μM). Shows cardioprotective effects.
1 Images
Chemical Structure - MMPSI, Caspase-3/7 Inhibitor I, caspase 3 and 7 inhibitor (AB145046)
  • Chemical Structure

Lab

Chemical Structure - MMPSI, Caspase-3/7 Inhibitor I, caspase 3 and 7 inhibitor (AB145046)

2D chemical structure image of ab145046, MMPSI, Caspase-3/7 Inhibitor I, caspase 3 and 7 inhibitor

Key facts

CAS number

220509-74-0

Purity

>98%

Form

Solid

form

Formulation

Constituents: 100% MMPSI, Caspase-3/7 Inhibitor I

Molecular weight

324.35 Da

Molecular formula

C<sub>1</sub><sub>4</sub>H<sub>1</sub><sub>6</sub>N<sub>2</sub>O<sub>5</sub>S

PubChem

9840223

Nature

Synthetic

Solubility

Soluble in ethanol to 10 mM

Soluble in DMSO to 100 mM

Biochemical name

Caspase-3/7 Inhibitor I

Biological description

Selective caspase 3 and 7 inhibitor (IC50 = 1.7 μM, caspase-3). Reduces ischemic-induced apoptosis (IC50 = 0.5 μM). Shows cardioprotective effects.

Canonical smiles

COCC1CCCN1S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O

Isomeric smiles

COC[C@@H]1CCCN1S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O

InChi

InChI=1S/C14H16N2O5S/c1-21-8-9-3-2-6-16(9)22(19,20)10-4-5-12-11(7-10)13(17)14(18)15-12/h4-5,7,9H,2-3,6,8H2,1H3,(H,15,17,18)/t9-/m0/s1

InChiKey

SLQMNVJNDYLJSF-VIFPVBQESA-N

IUPAC Name

5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
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Product protocols

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Publications (4)

Recent publications for all applications. Explore the full listand refine your search

Journal of biochemical and molecular toxicology 39:e70105 PubMed40067291

2025

Induction of miR-224 by Reactive Oxygen Species Regulates RASSF6 and Thus Modulates Malignant Behaviors and Chemosensitivity in Esophageal Squamous Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Liu,Yina Wang,Adili Salai,Yueying Yang,Yang Wang

Immunity, inflammation and disease 11:e1102 PubMed38156384

2024

PRMT5 participates in B cell overactivation in patients with primary Sjogren's syndrome (pSS) through RSAD2-mediated NF-κB signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Zhu,Jian Zheng,Yan Zhou,Tong Wu,Tiantian Zhu

iScience 26:107348 PubMed37554442

2023

Tumor-derived covalent organic framework nanozymes for targeted chemo-photothermal combination therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Shengnan Zhou,Tian Tian,Tao Meng,Jin Wu,Danyou Hu,Qiaobo Liao,Jialu Zhuang,Hua Wang,Guiyang Zhang

Acta biochimica Polonica 69:91-100 PubMed35143137

2022

Naringenin and morin reduces insulin resistance and endometrial hyperplasia in the rat model of polycystic ovarian syndrome through enhancement of inflammation and autophagic apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Yang,Jiuying Liu,Weiwei Xu
View all publications
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