Monastrol, cell permeable mitosis inhibitor

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(3 Publications)

MW 292.36 Da, Purity >99%. A potent, cell-permeable, small molecule mitosis inhibitor. It arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC₅₀ = 14 μM).

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1,8-cineole 2-exo-monooxygenase, AHDC, ALDC, ALDH 1, ALDH 11, ALDH class 1, ALDH class 2, ALDH-E1, ALDH-E2, ALDHI, ALDM, ALHDII, Acetaldehyde dehydrogenase 1, Acetaldehyde dehydrogenase 2, Albendazole monooxygenase, Albendazole sulfoxidase, Aldehyde dehydrogenase 1, Aldehyde dehydrogenase 1 family member A1, Aldehyde dehydrogenase 1 soluble, Aldehyde dehydrogenase 1A1, Aldehyde dehydrogenase 2 family, Aldehyde dehydrogenase 2 family (mitochondrial), Aldehyde dehydrogenase cytosolic, Aldehyde dehydrogenase liver cytosolic, Aldehyde dehydrogenase mitochondrial, Aldh, CP33, CP34, CP3A4_HUMAN, CPC12, CPC8, CPC9, CPCJ, CYP2C, CYP2C10, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, EG5, Glucocorticoid inducible P450, HKSP, HLP, KIF11_HUMAN, KNSL1, Kinesin family member 11, Kinesin-like protein 1, Kinesin-like protein KIF11, Kinesin-like spindle protein HKSP, Kinesin-related motor protein Eg5, Liver mitochondrial ALDH, MCLMR, MGC126680, MGC1806, MGC2318, Mitochondrial aldehyde dehydrogenase 2, NF 25, Nifedipine oxidase, Nucleus encoded mitochondrial aldehyde dehydrogenase 2, P450 III steroid inducible, P450 PB 1, P450 PCN1, P450, family III, P450C2C, P450C3, P450IIC19, P450IIC9, PUMB 1, Quinine 3-monooxygenase, RALDH 1, Retinal dehydrogenase 1, Retinaldehyde dehydrogenase 1, TR-interacting protein 5, TRIP-5, Taurochenodeoxycholate 6-alpha-hydroxylase, Thyroid receptor-interacting protein 5, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4