MW 692.86 g/mol.
Na+ ionophore. Forms lipophilic complexes with monovalent cations to induce Na+ influx and H+/K+ efflux. Increases intracellular Ca2+ levels. Exhibits diverse biological actions; displays antibacterial properties and modulates ion gradients and intracellular pH. Apoptosis inducer.
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- Antibiotics (Basel, Switzerland) 12:2023Effects of Monensin and Rapamycin Combination Therapy on Tumor Growth and Apoptosis in a Xenograft Mouse Model of Neuroblastoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSema Serter Kocoglu,Fatma Bahar Sunay,Pakize Nur AkkayaPubMed 37370314
- Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10:e22062122023Engineered Microparticles for Treatment of Murine Brain Metastasis by Reprograming Tumor Microenvironment and Inhibiting MAPK Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLisen Lu,Huaduan Zi,Jie Zhou,Jing Huang,Zihan Deng,Zijian Tang,Li Li,Xiujuan Shi,Pui-Chi Lo,Jonathan F Lovell,Deqiang Deng,Chao Wan,Honglin JinPubMed 36698296
- Nature communications 13:65892022Spatially resolved phosphoproteomics reveals fibroblast growth factor receptor recycling-driven regulation of autophagy and survival.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJoanne Watson,Harriet R Ferguson,Rosie M Brady,Jennifer Ferguson,Paul Fullwood,Hanyi Mo,Katherine H Bexley,David Knight,Gareth Howell,Jean-Marc Schwartz,Michael P Smith,Chiara FrancavillaPubMed 36329028
- International journal of medical sciences 18:3516-35252021PLK1 Inhibition Induces Immunogenic Cell Death and Enhances Immunity against NSCLC.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJie Zhou,Qifan Yang,Lisen Lu,Zhan Tuo,Zhexing Shou,Jing ChengPubMed 34522178
- Theranostics 10:9332-93472020USP7 targeting modulates anti-tumor immune response by reprogramming Tumor-associated Macrophages in Lung Cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaomeng Dai et. al.PubMed 32802195
- International journal of cancer 146:1421-14342019Interleukin-33 activates and recruits natural killer cells to inhibit pulmonary metastatic cancer development.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLu Qi,Qiuyan Zhang,Yuhui Miao,Wenyao Kang,Zhigang Tian,Damo Xu,Weihua Xiao,Fang FangPubMed 31709531
- Immunology letters 216:36-422019Hypoxia enhances IL-10-producing B cell generation through upregulating high-mobility group B1 on tumor cell-released autophagosomes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYue Zhang,Ning Pan,Yemeng Sheng,Meng Zhou,Zhifa Wen,Yongqiang Chen,Fang Huang,Li-Xin WangPubMed 31568811
- Oncoimmunology 5:e11804852016Tumor-released autophagosomes induce IL-10-producing B cells with suppressive activity on T lymphocytes via TLR2-MyD88-NF-κB signal pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMeng Zhou et. al.PubMed 27622036
Key facts
- CAS number
- 22373-78-0
- Form
- Solid
- Source
- Streptomyces cinnamonensis
- Molecular weight
- 692.86 g/mol
- Nature
- Native
Recommended products
MW 692.86 g/mol.
Na+ ionophore. Forms lipophilic complexes with monovalent cations to induce Na+ influx and H+/K+ efflux. Increases intracellular Ca2+ levels. Exhibits diverse biological actions; displays antibacterial properties and modulates ion gradients and intracellular pH. Apoptosis inducer.
Key facts
- CAS number
- 22373-78-0
- Form
- Solid
- Source
- Streptomyces cinnamonensis
- Molecular weight
- 692.86 g/mol
- Nature
- Native
- Solubility
Soluble in ethanol to 100 mM.
- Biological description
Na+ ionophore. Forms lipophilic complexes with monovalent cations to induce Na+ influx and H+/K+ efflux. Increases intracellular Ca2+ levels. Exhibits diverse biological actions; displays antibacterial properties and modulates ion gradients and intracellular pH. Apoptosis inducer.
- Isomeric SMILES
- OC[C@]1(O)O[C@@H]([C@@H](C)C[C@H]1C)[C@H]2C[C@H](C)[C@@H](O2)[C@]3(CC)CC[C@@H](O3)[C@]5(C)CC[C@]4(C[C@H](O)C[C@](C)(O4)[C@@H](C)[C@@H](OC)C(C)C(=O)O)O5
- InChI
- InChI=1S/C36H62O11/c1-10-34(30-21(3)16-26(43-30)28-20(2)15-22(4)36(41,19-37)45-28)12-11-27(44-34)32(7)13-14-35(46-32)18-25(38)17-33(8,47-35)24(6)29(42-9)23(5)31(39)40/h20-30,37-38,41H,10-19H2,1-9H3,(H,39,40)/t20-,21-,22+,23?,24-,25+,26+,27+,28-,29-,30+,32-,33-,34-,35-,36-/m0/s1
- InChIKey
- CPYYPAIYMVJXKK-FLOCGDGMSA-N
- IUPAC name
- 4-[2-[5-Ethyl-5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]- 3-methyloxolan-2-yl]oxolan-2-yl]- 9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]-3-methoxy-2-methylpentanoic acid sodium salt
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - Monensin sodium salt, Na+ ionophore (ab120499)
2D chemical structure image of ab120499, Monensin sodium salt, Na+ ionophore
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