AB120499

Monensin sodium salt, Na+ ionophore

Name: Monensin sodium salt, Na+ ionophore (CAS 22373-78-0) | Abcam
Brand: Abcam Limited
SKU: AB120499
Price: 45 USD
Availability: InStock

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(16 Publications)

MW 692.86 g/mol. Na⁺ ionophore. Forms lipophilic complexes with monovalent cations to induce Na⁺ influx and H⁺/K⁺ efflux. Increases intracellular Ca²⁺ levels. Exhibits diverse biological actions; displays antibacterial properties and modulates ion gradients and intracellular pH. Apoptosis inducer.

1 Images

Chemical Structure - Monensin sodium salt, Na+ ionophore (AB120499)

Chemical Structure

Lab

Chemical Structure - Monensin sodium salt, Na+ ionophore (AB120499)

2D chemical structure image of ab120499, Monensin sodium salt, Na+ ionophore

Key facts

CAS number

22373-78-0

Form

Solid

form

Source

Streptomyces cinnamonensis

Molecular weight

692.86 g/mol

Nature

Native

Solubility

Soluble in ethanol to 100 mM

Biological description

Na⁺ ionophore. Forms lipophilic complexes with monovalent cations to induce Na⁺ influx and H⁺/K⁺ efflux. Increases intracellular Ca²⁺ levels. Exhibits diverse biological actions; displays antibacterial properties and modulates ion gradients and intracellular pH. Apoptosis inducer.

Isomeric smiles

OC[C@]1(O)O[C@@H]([C@@H](C)C[C@H]1C)[C@H]2C[C@H](C)[C@@H](O2)[C@]3(CC)CC[C@@H](O3)[C@]5(C)CC[C@]4(C[C@H](O)C[C@](C)(O4)[C@@H](C)[C@@H](OC)C(C)C(=O)O)O5

InChi

InChI=1S/C36H62O11/c1-10-34(30-21(3)16-26(43-30)28-20(2)15-22(4)36(41,19-37)45-28)12-11-27(44-34)32(7)13-14-35(46-32)18-25(38)17-33(8,47-35)24(6)29(42-9)23(5)31(39)40/h20-30,37-38,41H,10-19H2,1-9H3,(H,39,40)/t20-,21-,22+,23?,24-,25+,26+,27+,28-,29-,30+,32-,33-,34-,35-,36-/m0/s1

InChiKey

CPYYPAIYMVJXKK-FLOCGDGMSA-N

IUPAC Name

4-[2-[5-Ethyl-5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]- 3-methyloxolan-2-yl]oxolan-2-yl]- 9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]-3-methoxy-2-methylpentanoic acid sodium salt

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Store under desiccating conditions|The product can be stored for up to 12 months

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Product protocols

Visit the General protocols
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Publications (16)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular and molecular medicine 29:e70525 PubMed40159652

2025

Unravelling Cancer Immunity: Coagulation.Sig and BIRC2 as Predictive Immunotherapeutic Architects.

Applications

Unspecified application

Species

Unspecified reactive species

Ziang Yao,Jun Fan,Yucheng Bai,Jiakai He,Xiang Zhang,Renquan Zhang,Lei Xue

Journal of nanobiotechnology 23:239 PubMed40121481

2025

Radiotherapy-derived engineered stem cell exosomes improve anti-glioma immunotherapy by promoting the formation of tertiary lymphoid structure and improve the release of type I interferon.

Applications

Unspecified application

Species

Unspecified reactive species

Man Li,Lisen Lu,Qiuhong Bao,Minghui Zhou,Bin Nie,Yanchao Liu,Kai Shu,Ting Lei,Mingxin Zhu

Exploration (Beijing, China) 4:20240027 PubMed39713206

2024

Bioengineer mesenchymal stem cell for treatment of glioma by IL-12 mediated microenvironment reprogramming and nCD47-SLAMF7 mediated phagocytosis regulation of macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Man Li,Lisen Lu,Qungen Xiao,Ali Abdi Maalim,Bin Nie,Yanchao Liu,Ulf D Kahlert,Kai Shu,Ting Lei,Mingxin Zhu

Journal of nanobiotechnology 22:156 PubMed38589867

2024

Induction of therapeutic immunity and cancer eradication through biofunctionalized liposome-like nanovesicles derived from irradiated-cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Suke Deng,Jiacheng Wang,Yan Hu,Yajie Sun,Xiao Yang,Bin Zhang,Yue Deng,Wenwen Wei,Zhanjie Zhang,Lu Wen,You Qin,Fang Huang,Yuhan Sheng,Chao Wan,Kunyu Yang

Theranostics 14:1224-1240 PubMed38323313

2024

Tumor cell senescence-induced macrophage CD73 expression is a critical metabolic immune checkpoint in the aging tumor microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Yue Deng,Qinyan Chen,Xiao Yang,Yajie Sun,Bin Zhang,Wenwen Wei,Suke Deng,Jingshu Meng,Yan Hu,Yijun Wang,Zhanjie Zhang,Lu Wen,Fang Huang,Chao Wan,Kunyu Yang

Molecular therapy : the journal of the American Society of Gene Therapy 32:411-425 PubMed38098229

2023

Irradiated engineered tumor cell-derived microparticles remodel the tumor immune microenvironment and enhance antitumor immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Hu,Yajie Sun,Zhiyun Liao,Dandan An,Xixi Liu,Xiao Yang,Yu Tian,Suke Deng,Jingshu Meng,Yijun Wang,Jie Li,Yue Deng,Zhiyuan Zhou,Qinyan Chen,Ying Ye,Wenwen Wei,Bian Wu,Jonathan F Lovell,Honglin Jin,Fang Huang,Chao Wan,Kunyu Yang

Cell reports. Medicine 4:101303 PubMed38029750

2023

Engineering irradiated tumor-derived microparticles as personalized vaccines to enhance anti-tumor immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Yajie Sun,Yu Tian,Shuhui Wu,Ai Huang,Yan Hu,Zhiyun Liao,Michelle Swift,Suke Deng,Xiao Yang,Bin Zhang,Zhanjie Zhang,Bian Wu,Jing Huang,Ke Jiang,Fang Huang,Honglin Jin,Chao Wan,Kunyu Yang

Antibiotics (Basel, Switzerland) 12: PubMed37370314

2023

Effects of Monensin and Rapamycin Combination Therapy on Tumor Growth and Apoptosis in a Xenograft Mouse Model of Neuroblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Sema Serter Kocoglu,Fatma Bahar Sunay,Pakize Nur Akkaya

Antibiotics (Basel, Switzerland) 12: PubMed36978413

2023

Monensin, an Antibiotic Isolated from , Regulates Human Neuroblastoma Cell Proliferation via the PI3K/AKT Signaling Pathway and Acts Synergistically with Rapamycin.

Applications

Unspecified application

Species

Unspecified reactive species

Sema Serter Kocoglu,Mücahit Secme,Ceren Oy,Gözde Korkusuz,Levent Elmas

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10:e2206212 PubMed36698296

2023

Engineered Microparticles for Treatment of Murine Brain Metastasis by Reprograming Tumor Microenvironment and Inhibiting MAPK Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Lisen Lu,Huaduan Zi,Jie Zhou,Jing Huang,Zihan Deng,Zijian Tang,Li Li,Xiujuan Shi,Pui-Chi Lo,Jonathan F Lovell,Deqiang Deng,Chao Wan,Honglin Jin

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Monensin sodium salt, Na+ ionophore

Chemical Structure - Monensin sodium salt, Na+ ionophore (AB120499)

Key facts

CAS number

Form

Source

Molecular weight

Nature

Solubility

Biological description

Isomeric smiles

InChi

InChiKey

IUPAC Name

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Publications (16)

Complementary Products

Biochemicals

Secondary Antibodies

Primary Antibodies

Biochemicals

Product promise