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AB144306

Monosodium urate (PBS solution), NLRP3/NALP3 inflammasome activator

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(1 Publication)

MW 190.09 Da. NLRP3/NALP3 inflammasome activator. Stimulates caspase-1 activating NLRP3/NALP3 inflammasome, results in active IL-1β and IL-18 production. Active in vitro and in vivo.
1 Images
Chemical Structure - Monosodium urate (PBS solution), NLRP3/NALP3 inflammasome activator (AB144306)
  • Chemical Structure

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Chemical Structure - Monosodium urate (PBS solution), NLRP3/NALP3 inflammasome activator (AB144306)

2D chemical structure image of ab144306, Monosodium urate (PBS solution), NLRP3/NALP3 inflammasome activator

Key facts

CAS number

1198-77-2

Form

Liquid

form

Molecular weight

190.09 Da

Molecular formula

C<sub>5</sub>H<sub>3</sub>N<sub>4</sub>NaO<sub>3</sub>

PubChem

23697816

Nature

Synthetic

Biochemical name

Sodium urate

Biological description

NLRP3/NALP3 inflammasome activator. Stimulates caspase-1 activating NLRP3/NALP3 inflammasome, results in active IL-1β and IL-18 production. Active in vitro and in vivo.

Canonical smiles

C12=C(NC(=O)NC1=O)[N-]C(=O)N2.[Na+]

InChi

InChI=1S/C5H4N4O3.Na/c10-3-1-2(7-4(11)6-1)8-5(12)9-3;/h(H4,6,7,8,9,10,11,12);/q;+1/p-1

InChiKey

NAFSTSRULRIERK-UHFFFAOYSA-M

IUPAC Name

sodium;3,7-dihydropurin-9-ide-2,6,8-trione

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Complementary Products

Primary Antibodies

AB263899

Anti-NLRP3 antibody [EPR23094-1]

KO Validated|RabMAb|Recombinant

Western blot - Anti-NLRP3 antibody [EPR23094-1] (AB263899)

  • 4
  • 2
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB215203

Anti-cleaved N-terminal GSDMD antibody [EPR20829-408]

RabMAb|Recombinant

Western blot - Anti-cleaved N-terminal GSDMD antibody [EPR20829-408] (AB215203)

  • 5
  • 4
Primary Antibodies

AB309497

Anti-TMS1/ASC antibody [RM1049]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMS1/ASC antibody [RM1049] (AB309497)

  • 0
  • 0
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Drug development research 83:1654-1672 PubMed36069386

2022

Calycosin represses AIM2 inflammasome-mediated inflammation and pyroptosis to attenuate monosodium urate-induced gouty arthritis through NF-κB and p62-Keap1 pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Tian,Dapeng Zhou,Liangbi Xiang,Bing Xie,Baichuan Wang,Yang Li,Xinwei Liu
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