MW 229.7 Da, Purity >99%. Subtype selective and potent non-competitive mGlu5 antagonist (IC50 = 36 nM). Central effects following systemic administration in vivo.
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- Journal of neuroscience research 101:1170-11872023Metabotropic glutamate receptor 5-mediated inhibition of inward-rectifying K channel 4.1 contributes to orofacial ectopic mechanical allodynia following inferior alveolar nerve transection in male mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYi-Ke Li,Yan-Yan Zhang,Jiu Lin,Ya-Jing Liu,Yue-Ling Li,Yu-Heng Feng,Jia-Shuo Zhao,Cheng Zhou,Fei Liu,Jie-Fei ShenPubMed 36807930
- The Journal of neuroscience : the official journal of the Society for Neuroscience 42:6211-62202022Induction of Activity-Dependent Plasticity at Auditory Nerve Synapses.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNicole F Wong,Matthew A Xu-FriedmanPubMed 35790402
- Biology of reproduction 107:916-9272022Glutamate can act as a signaling molecule in mouse preimplantation embryos†.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlexandra Špirková,Veronika Kovaříková,Zuzana Šefčíková,Jozef Pisko,Martina Kšiňanová,Juraj Koppel,Dušan Fabian,Štefan ČikošPubMed 35746896
- eLife 8:2019ON selectivity in the visual system is a multisynaptic process involving both glutamatergic and GABAergic inhibition.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSebastian Molina-Obando et. al.PubMed 31535971
- Scientific reports 8:44072018Direct coupling of detergent purified human mGlu receptor to the heterotrimeric G proteins Gq and Gs.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChady Nasrallah et. al.PubMed 29535347
- Scientific reports 7:448172017Ca-permeable AMPA receptors in mouse olfactory bulb astrocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDamian Droste et. al.PubMed 28322255
- Frontiers in cellular neuroscience 10:2522016Separate Ionotropic and Metabotropic Glutamate Receptor Functions in Depotentiation vs. LTP: A Distinct Role for Group1 mGluR Subtypes and NMDARs.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAmira Latif-Hernandez et. al.PubMed 27872582
- Scientific reports 6:284542016Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMichelangelo Colavita et. al.PubMed 27345695
- Frontiers in cellular neuroscience 9:3452015Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLuca Bragina et. al.PubMed 26388733
- Journal of neurophysiology 113:3634-452015Different pools of glutamate receptors mediate sensitivity to ambient glutamate in the cochlear nucleus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYang Yang et. al.PubMed 25855696
Key facts
- CAS number
- 219911-35-0
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 229.7 Da
- Molecular formula
- C14H12ClN
- PubChem identifier
- 9794588
- Nature
- Synthetic
Associated Products
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1 product for Alternative Product
Alternative names
GLUR, GPRC1E, GRM5_HUMAN, Glutamate receptor metabotropic 5, Metabotropic glutamate receptor 5, Metabotropic glutamate receptor 5 variant F, Metabotropic glutamate receptor 5 variant G, Metabotropic glutamate receptor 5 variant H, PPP1R86, Protein phosphatase 1 regulatory subunit 86, Smp_128940, mGlu5, mGluR5
Recommended products
MW 229.7 Da, Purity >99%. Subtype selective and potent non-competitive mGlu5 antagonist (IC50 = 36 nM). Central effects following systemic administration in vivo.
Key facts
- CAS number
- 219911-35-0
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 229.7 Da
- Molecular formula
- C14H12ClN
- PubChem identifier
- 9794588
- Nature
- Synthetic
- Solubility
Soluble in water to 5 mM, in ethanol to 100 mM and in DMSO to 100 mM.
- Biochemical name
- MPEP hydrochloride
- Biological description
Subtype selective and potent non-competitive mGlu5 antagonist (IC50 = 36 nM). Central effects following systemic administration in vivo.
- Canonical SMILES
- CC1=NC(=CC=C1)C#CC2=CC=CC=C2.Cl
- InChI
- InChI=1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
- InChIKey
- PKDHDJBNEKXCBI-UHFFFAOYSA-N
- IUPAC name
- 2-methyl-6-(2-phenylethynyl)pyridine;hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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4 product images
Chemical Structure - MPEP hydrochloride, mGlu5 antagonist (ab120008)
2D chemical structure image of ab120008, MPEP hydrochloride, mGlu5 antagonist
Image from Krishnan B, et al. Plos One, 6(9), e25639. Fig 7,; doi: 10.1371/journal.pone.0025639Functional Studies - MPEP hydrochloride, mGlu5 antagonist (ab120008)
Basal PLD activity is strongly stimulated by the D1/5R agonist and blocked by the D1/5R, mGluR5, mGluR1, and the PLD-linked mGluR antagonists in the amygdala of cocaine CPP animals.
The dotted line indicates PLD activity associated with control slices (no EtOH added) which was determined for each animal and used to calculate the change in PLD activity levels with EtOH and/or drug application.
Image from Gómez-Gonzalo M et al., PLoS Biol. 2010;8(4):e1000352. Fig 2.; doi: 10.1371/journal.pbio.1000352. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Functional Studies - MPEP hydrochloride, mGlu5 antagonist (ab120008)
Astrocyte Ca2+ signal inhibition does not affect interictal discharges. (A–D) Mean percentage of astrocytes activated by the ictal discharges (A), mean duration (B) and frequency (C) of the ictal discharge, and mean frequency of interictal discharges (D) under different experimental conditions in EC slice preparations. Controls (n=16), MPEP (ab120008) (n=7), PPADS (PPADS, P2 purinergic receptor antagonist ab120009) (n=9), and MPEP+PPADS (n=3). A single asterisk (*) indicates p<0.05; double asterisks (**), p<0.01.
Image from Gómez-Gonzalo M et al., PLoS Biol. 2010;8(4):e1000352. Fig 6(A).; doi: 10.1371/journal.pbio.1000352.Functional Studies - MPEP hydrochloride, mGlu5 antagonist (ab120008)
Ca2+ signal from a field A neuron, a field B neuron, and field A astrocytes in response to repetitive episodes of NMDA stimulation (black arrowheads). The NMDA stimulation that evoked an ictal discharge became ineffective after blocking the astrocyte response by bath perfusion with MPEP (ab120008) and PPADS (PPADS, P2 purinergic receptor antagonist ab120009). An ictal discharge could be recovered by increasing the number of NMDA puffs (white arrowheads). A double NMDA pulse evoked both astrocyte activation and the ictal discharge after inhibitor washout.
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