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AB120035

MTEP hydrochloride, mGlu5 antagonist

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(25 Publications)

MW 236.72 Da, Purity >99%. Brain penetrant, potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki = 16 nM). In vivo anxiolytic, devoid of side effects seen with MPEP and benzodiazepines. Soluble in 1 ml water to give specified mM/ml concentration.
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Chemical Structure - MTEP hydrochloride, mGlu5 antagonist (AB120035)
  • Chemical Structure

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Chemical Structure - MTEP hydrochloride, mGlu5 antagonist (AB120035)

2D chemical structure image of ab120035, MTEP hydrochloride, mGlu5 antagonist

Key facts

CAS number

1186195-60-7

Purity

>99%

Form

Solid

form

Molecular weight

236.72 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>9</sub>ClN<sub>2</sub>S

PubChem

45073467

Nature

Synthetic

Biochemical name

MTEP hydrochloride

Biological description

Brain penetrant, potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki = 16 nM). In vivo anxiolytic, devoid of side effects seen with MPEP and benzodiazepines. Soluble in 1 ml water to give specified mM/ml concentration.

Canonical smiles

CC1=NC(=CS1)C#CC2=CN=CC=C2.Cl

InChi

InChI=1S/C11H8N2S.ClH/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10;/h2-3,6-8H,1H3;1H

InChiKey

YCIOJDKGCWAHLR-UHFFFAOYSA-N

IUPAC Name

2-methyl-4-(2-pyridin-3-ylethynyl)-1,3-thiazole;hydrochloride

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Complementary Products

Biochemicals

AB120007

(S)-3,5-DHPG, group I mGlu agonist

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Biochemicals

AB120003

D-AP5, NMDA glutamate site antagonist

Chemical Structure - D-AP5, NMDA glutamate site antagonist (AB120003)

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Biochemicals

AB120042

SR95531 (Gabazine), GABAA antagonist

Chemical Structure - SR95531 (Gabazine), GABAA antagonist (AB120042)

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Biochemicals

AB120337

CGP 55845 hydrochloride, GABAB antagonist

Functional Studies - CGP 55845 hydrochloride, GABAB antagonist (AB120337)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (25)

Recent publications for all applications. Explore the full list and refine your search

Journal of Alzheimer's disease : JAD 89:335-350 PubMed35871344

2022

Long-Term Depression-Inducing Low Frequency Stimulation Enhances p-Tau181 and p-Tau217 in an Age-Dependent Manner in Live Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Yangyang Zhang,Yin Yang,Zhengtao Hu,Manyi Zhu,Shuangying Qin,Pengpeng Yu,Bo Li,Jitian Xu,Tomas Ondrejcak,Igor Klyubin,Michael J Rowan,Neng-Wei Hu

Frontiers in cell and developmental biology 10:844378 PubMed35646890

2022

Different Aberrant Changes of mGluR5 and Its Downstream Signaling Pathways in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Hu,Cao Chen,Ying Xia,Jia Chen,Wei Yang,Lin Wang,Dong-Dong Chen,Yue-Zhang Wu,Qin Fan,Xiao-Xi Jia,Kang Xiao,Qi Shi,Zhi-Bao Chen,Xiao-Ping Dong

Translational psychiatry 12:96 PubMed35260557

2022

Inhibition of the ISR abrogates mGluR5-dependent long-term depression and spatial memory deficits in a rat model of Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Zhengtao Hu,Pengpeng Yu,Yangyang Zhang,Yin Yang,Manyi Zhu,Shuangying Qin,Ji-Tian Xu,Dongxiao Duan,Yong Wu,Deguo Wang,Michael J Rowan,Neng-Wei Hu

The Journal of neuroscience : the official journal 37:4359-4369 PubMed28320841

2017

Prefrontal Cortex K2 Channels Regulate mGlu-Dependent Plasticity and Extinction of Alcohol-Seeking Behavior.

Applications

Unspecified application

Species

Unspecified reactive species

Reginald Cannady,Justin T McGonigal,Ryan J Newsom,John J Woodward,Patrick J Mulholland,Justin T Gass

Nature neuroscience 19:1225-33 PubMed27428652

2016

Infantile amnesia reflects a developmental critical period for hippocampal learning.

Applications

Unspecified application

Species

Unspecified reactive species

Alessio Travaglia,Reto Bisaz,Eric S Sweet,Robert D Blitzer,Cristina M Alberini

American journal of physiology. Renal physiology 308:F832-8 PubMed25673810

2015

Role of spinal metabotropic glutamate receptor 5 in pudendal inhibition of the nociceptive bladder reflex in cats.

Applications

Unspecified application

Species

Unspecified reactive species

Jeremy N Reese,Marc J Rogers,Zhiying Xiao,Bing Shen,Jicheng Wang,Zeyad Schwen,James R Roppolo,William C de Groat,Changfeng Tai

Journal of medicinal chemistry 57:9130-8 PubMed25330258

2014

Radiosynthesis and evaluation of an 18F-labeled positron emission tomography (PET) radioligand for metabotropic glutamate receptor subtype 4 (mGlu4).

Applications

Unspecified application

Species

Unspecified reactive species

Kun-Eek Kil,Pekka Poutiainen,Zhaoda Zhang,Aijun Zhu,Ji-Kyung Choi,Kimmo Jokivarsi,Anna-Liisa Brownell

The Journal of neuroscience : the official journal of the Society for Neuroscience 34:7562-74 PubMed24872560

2014

Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Justin T Gass,Heather Trantham-Davidson,Amanda S Kassab,William B Glen,M Foster Olive,L Judson Chandler

Nature communications 5:3374 PubMed24594908

2014

mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Neng-Wei Hu,Andrew J Nicoll,Dainan Zhang,Alexandra J Mably,Tiernan O'Malley,Silvia A Purro,Cassandra Terry,John Collinge,Dominic M Walsh,Michael J Rowan

Bioorganic & medicinal chemistry 21:5955-62 PubMed23978356

2013

Radiosynthesis of N-(4-chloro-3-[(11)C]methoxyphenyl)-2-picolinamide ([(11)C]ML128) as a PET radiotracer for metabotropic glutamate receptor subtype 4 (mGlu4).

Applications

Unspecified application

Species

Rat

Kun-Eek Kil,Zhaoda Zhang,Kimmo Jokivarsi,Chunyu Gong,Ji-Kyung Choi,Sreekanth Kura,Anna-Liisa Brownell
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