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AB144486

MTEP hydrochloride (mM/ml), mGlu5 antagonist

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(13 Publications)

MW 236.72 Da, Purity >99%. Brain penetrant, potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki = 16 nM). In vivo anxiolytic, devoid of side effects seen with MPEP and benzodiazepines. Soluble in 1 ml water to give specified mM/ml concentration.
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Chemical Structure - MTEP hydrochloride (mM/ml), mGlu5 antagonist (AB144486)
  • Chemical Structure

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Chemical Structure - MTEP hydrochloride (mM/ml), mGlu5 antagonist (AB144486)

2D chemical structure image of ab144486, MTEP hydrochloride (mM/ml), mGlu5 antagonist

Key facts

CAS number

1186195-60-7

Purity

>99%

Form

Solid

form

Molecular weight

236.72 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>9</sub>ClN<sub>2</sub>S

PubChem

45073467

Nature

Synthetic

Biochemical name

MTEP hydrochloride

Biological description

Brain penetrant, potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki = 16 nM). In vivo anxiolytic, devoid of side effects seen with MPEP and benzodiazepines. Soluble in 1 ml water to give specified mM/ml concentration.

Canonical smiles

CC1=NC(=CS1)C#CC2=CN=CC=C2.Cl

InChi

InChI=1S/C11H8N2S.ClH/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10;/h2-3,6-8H,1H3;1H

InChiKey

YCIOJDKGCWAHLR-UHFFFAOYSA-N

IUPAC Name

2-methyl-4-(2-pyridin-3-ylethynyl)-1,3-thiazole;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (13)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pharmacology 2:93 PubMed22232603

2012

Differential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration.

Applications

Unspecified application

Species

Unspecified reactive species

Richard M Cleva,Lucas R Watterson,Meagan A Johnson,M Foster Olive

ACS chemical neuroscience 2:471-482 PubMed21927650

2011

(3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction.

Applications

Unspecified application

Species

Unspecified reactive species

Craig W Lindsley,Brittney S Bates,Usha N Menon,Satyawan B Jadhav,Alexander S Kane,Carrie K Jones,Alice L Rodriguez,P Jeffrey Conn,Christopher M Olsen,Danny G Winder,Kyle A Emmitte

Pharmacology, biochemistry, and behavior 99:619-25 PubMed21703298

2011

Behavioral consequences of the mGlu5 receptor antagonist MTEP in immature rats.

Applications

Unspecified application

Species

Unspecified reactive species

Kateřina Tichá,Anna Mikulecká,Pavel Mareš

The Journal of neuroscience : the official journal of the Society for Neuroscience 31:8669-80 PubMed21653871

2011

mGluR control of interneuron output regulates feedforward tonic GABAA inhibition in the visual thalamus.

Applications

Unspecified application

Species

Unspecified reactive species

Adam C Errington,Giuseppe Di Giovanni,Vincenzo Crunelli,David W Cope

Pharmacological reports : PR 62:1051-61 PubMed21273662

2011

Neuroprotective potential of mGluR5 antagonist MTEP: effects on kainate-induced excitotoxicity in the rat hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

Helena Domin,Barbara Zięba,Krystyna Gołembiowska,Magdalena Kowalska,Anna Dziubina,Maria Śmiałowska

Nature neuroscience 13:1216-24 PubMed20852624

2010

Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95.

Applications

Unspecified application

Species

Unspecified reactive species

Jihoon Jo,Gi Hoon Son,Bryony L Winters,Myung Jong Kim,Daniel J Whitcomb,Bryony A Dickinson,Youn-Bok Lee,Kensuke Futai,Mascia Amici,Morgan Sheng,Graham L Collingridge,Kwangwook Cho

Epilepsia 51 Suppl 3:24-6 PubMed20618395

2010

Metabotropic glutamate receptors as a target for anticonvulsant and anxiolytic action in immature rats.

Applications

Unspecified application

Species

Unspecified reactive species

Pavel Mares,Anna Mikulecká,Katerina Tichá,Denisa Lojková-Janecková,Hana Kubová

British journal of pharmacology 159:534-42 PubMed20067474

2010

Cue-conditioned alcohol seeking in rats following abstinence: involvement of metabotropic glutamate 5 receptors.

Applications

Unspecified application

Species

Unspecified reactive species

C L Adams,J L Short,A J Lawrence

The Journal of neuroscience : the official journal of the Society for Neuroscience 29:9582-91 PubMed19641121

2009

Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens.

Applications

Unspecified application

Species

Unspecified reactive species

Joyce Besheer,Julie J M Grondin,Michael C Salling,Marina Spanos,Rebekah A Stevenson,Clyde W Hodge

Neurobiology of learning and memory 92:460-3 PubMed19439188

2009

Metabotropic glutamate receptor 5 in conditioned taste aversion learning.

Applications

Unspecified application

Species

Unspecified reactive species

A Simonyi,P Serfozo,K E Parker,A K Ramsey,T R Schachtman
View all publications
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