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AB144307

MTEP, mGluR5 antagonist

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MW 200.26 Da, Purity >99%. Potent and selective mGluR5 antagonist. Acts as a negative allosteric modulator at mGluR5. Shows 5-fold more potent anxiolytic effects than MPEP (ab120008). Shows antidepressant and neuroprotective effects in vivo. Orally active. Blood-brain barrier permeable.

View Alternative Names

GPRC1E, GRM5_HUMAN, Glutamate receptor metabotropic 5, Metabotropic glutamate receptor 5, Metabotropic glutamate receptor 5 variant F, Metabotropic glutamate receptor 5 variant G, Metabotropic glutamate receptor 5 variant H, PPP1R86, Protein phosphatase 1 regulatory subunit 86, mGlu5, mGluR5

1 Images
Chemical Structure - MTEP, mGluR5 antagonist (AB144307)
  • Chemical Structure

Lab

Chemical Structure - MTEP, mGluR5 antagonist (AB144307)

2D chemical structure image of ab144307, MTEP, mGluR5 antagonist

Key facts

CAS number

329205-68-7

Purity

>99%

Form

Solid

form

Molecular weight

200.26 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>8</sub>N<sub>2</sub>S

PubChem

9794218

Nature

Synthetic

Solubility

Soluble in ethanol to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

2-Methyl-4-(pyridin-3-ylethynyl)thiazole

Biological description

Potent and selective mGluR5 antagonist. Acts as a negative allosteric modulator at mGluR5. Shows 5-fold more potent anxiolytic effects than MPEP (ab120008). Shows antidepressant and neuroprotective effects in vivo. Orally active. Blood-brain barrier permeable.

Canonical smiles

CC1=NC(=CS1)C#CC2=CN=CC=C2

InChi

InChI=1S/C11H8N2S/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10/h2-3,6-8H,1H3

InChiKey

NRBNGHCYDWUVLC-UHFFFAOYSA-N

IUPAC Name

2-methyl-4-(2-pyridin-3-ylethynyl)-1,3-thiazole

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Complementary Products

Biochemicals

AB120003

D-AP5, NMDA glutamate site antagonist

Chemical Structure - D-AP5, NMDA glutamate site antagonist (AB120003)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Primary Antibodies

AB76316

Anti-Metabotropic Glutamate Receptor 5 antibody [EPR2425Y]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Metabotropic Glutamate Receptor 5 antibody [EPR2425Y] (AB76316)

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Biochemicals

AB120007

(S)-3,5-DHPG, group I mGlu agonist

Functional Studies - (S)-3,5-DHPG, group I mGlu agonist (AB120007)

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