MW 492.5 Da, Purity >98%. Muramyl dipeptide is a synthetic immunoreactive peptide that activates NOD2 receptors. Induces polarization of proinflammatory Ly6Chigh into Ly6Clow patrolling monocytes. Also inhibits HIV replication in CD4⁺ H9 lymphocytes.
View Alternative Names
ACUG, AGTAVPRL, AII/AVP, Angiotensin/vasopressin receptor AII/AVP-like, Arthrocutaneouveal granulomatosis, BLAU, C1orf7, CARD15, CD, CIAS 1, CLR1.1, CLR16.3, Caspase recruitment domain family, member 15, Caspase recruitment domain protein 15, Caspase recruitment domain-containing protein 15, Caterpiller protein 1.1, Cold autoinflammatory syndrome 1, Cold autoinflammatory syndrome 1 protein, Cryopyrin, FCAS, FCU, Familial cold autoinflammatory syndrome, IBD1, Inflammatory bowel disease protein 1, LRR and PYD domains-containing protein 3, LRR containing protein, MWS, Muckle-Wells syndrome, NACHT, NACHT LRR and PYD containing protein 3, NALP 3, NALP3_HUMAN, NLR family pyrin domain containing 3, NLR family, CARD domain containing 2, NLRC2, NOD like receptor C2, NOD2 protein, NOD2B, NOD2_HUMAN, Nucleotide binding oligomerization domain containing 2, Nucleotide binding oligomerization domain, leucine rich repeat and CARD domain containing 2, Nucleotide-binding oligomerization domain-containing protein 2, PSORAS1, PYPAF 1, PYRIN-containing APAF1-like protein 1, nucleotide binding oligomerization domain 2
Product details
This product is manufactured by BioVision, an Abcam company and was previously called B2532 Muramyl Dipeptide. B2532-1 is the same size as the 1 mg size of ab287084.
Protect from moisture.
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These proteins detect intracellular changes related to infections or cellular stress. CARD15/NOD2 and NLRP3 function as part of multiprotein complexes called inflammasomes. These complexes trigger inflammation through the activation of caspase-1 which then processes pro-inflammatory cytokines like interleukin-1β. NOD2 responds specifically to muramyl dipeptide leading to nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway activation which enhances inflammation response.
Pathways
Both CARD15/NOD2 and NLRP3 are integral to immune system signaling pathways. NOD2 is central to the NF-κB signaling pathway. It also interacts with proteins like RIP2 to modulate immune response. NLRP3 activates inflammasomes contributing to the IL-1β processing pathway. These pathways influence how the immune system identifies and counteracts bacterial threats.
Publications (1)
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Renal failure 45:2259234 PubMed37732403
2023
Applications
Unspecified application
Species
Unspecified reactive species
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