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AB120094

Muscimol, GABAA agonist

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(22 Publications)

Muscimol (ab120094)(CAS: 2763-96-4) is potent, selective GABA A receptor agonist. MW 114.1 , Purity >99%.

- Available in different sizes to fit your experimental needs.

View Alternative Names

AW061132, B230208N19Rik, CAE 2, ECA 2, ECA4, ECA5, EIEE19, EJM, EJM5, GAA 5, GABA, GABA A, GABA A Receptor alpha 3, GABA A Receptor alpha 6 polypeptide, GABA A receptor alpha 6, GABA A receptor subunit alpha 2, GABA A receptor subunit alpha 6, GABA alpha receptor beta-2 subunit, GABA receptor Rho 2 subunit, GABA subunit A receptor alpha 6, GABA(A) receptor, GABA(A) receptor beta 1, GABA(A) receptor beta 2, GABA(A) receptor epsilon, GABA(A) receptor gamma 2, GABA(A) receptor subunit alpha-1, GABA(A) receptor subunit alpha-2, GABA(A) receptor subunit alpha-3, GABA(A) receptor subunit alpha-4, GABA(A) receptor subunit alpha-5, GABA(A) receptor subunit alpha-6, GABA(A) receptor subunit beta-1, GABA(A) receptor subunit beta-2, GABA(A) receptor subunit beta-3, GABA(A) receptor subunit delta, GABA(A) receptor subunit epsilon, GABA(A) receptor subunit gamma-1, GABA(A) receptor subunit gamma-2, GABA(A) receptor subunit gamma-3, GABA(A) receptor subunit pi, GABA(A) receptor subunit rho-1, GABA(A) receptor subunit rho-2, GABA(A) receptor subunit rho-3, GABA(A) receptor subunit theta, GABA(A) receptor, alpha 1, GABA(C) receptor, GABA-A receptor, beta-1 polypeptide, GABA-A receptor, beta-2 polypeptide, GABAA receptor beta 3 subunit, GABAA receptor subunit beta 3, GABR A2, GABR A3, GABR B3, GABR G3, GABRA 1, GABRA 5, GABRA 6, GABRA2 protein, GABRB2, GABRG 1, GABRG 2, GABRP, GABRR3, GARB1, GBRA1_HUMAN, GBRA2_HUMAN, GBRA3_HUMAN, GBRA4_HUMAN, GBRA5_HUMAN, GBRA6_HUMAN, GBRB1_HUMAN, GBRB2_HUMAN, GBRB3_HUMAN, GBRD_HUMAN, GBRE_HUMAN, GBRG1_HUMAN, GBRG2_HUMAN, GBRG3_HUMAN, GBRP_HUMAN, GBRR1_HUMAN, GBRR3_HUMAN, GBRT_HUMAN, GC138184, GEFSP 3, Gaba receptor alpha 1 polypeptide, GabaA/BZ, Gabre, Gabrq, Gamma Aminobutyric Acid A Receptor Beta 1, Gamma Aminobutyric Acid Receptor , beta-1, Gamma aminobutyric acid (GABA A) receptor subunit gamma 1, Gamma aminobutyric acid (GABA) A receptor alpha 1, Gamma aminobutyric acid (GABA) A receptor alpha 2, Gamma aminobutyric acid (GABA) A receptor alpha 3, Gamma aminobutyric acid (GABA) A receptor alpha 4, Gamma aminobutyric acid (GABA) A receptor beta 1, Gamma aminobutyric acid (GABA) A receptor beta 3, Gamma aminobutyric acid (GABA) A receptor epsilon, Gamma aminobutyric acid (GABA) A receptor gamma 2, Gamma aminobutyric acid (GABA) A receptor gamma 3, Gamma aminobutyric acid (GABA) A receptor pi, Gamma aminobutyric acid (GABA) A receptor, beta 2, Gamma aminobutyric acid A receptor alpha 1, Gamma aminobutyric acid A receptor alpha 2, Gamma aminobutyric acid A receptor alpha 3, Gamma aminobutyric acid A receptor alpha 4, Gamma aminobutyric acid A receptor alpha 6, Gamma aminobutyric acid A receptor beta 2, Gamma aminobutyric acid A receptor gamma 2, Gamma aminobutyric acid A receptor gamma 3, Gamma aminobutyric acid A receptor pi, Gamma aminobutyric acid A receptor, gamma 1, Gamma aminobutyric acid GABA A receptor alpha 5, Gamma aminobutyric acid GABA A receptor alpha 5 precursor, Gamma aminobutyric acid GABA A receptor alpha 6, Gamma aminobutyric acid GABA A receptor delta, Gamma aminobutyric acid receptor alpha 2 subunit, Gamma aminobutyric acid receptor alpha 4 subunit, Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor, Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor, Gamma aminobutyric acid receptor gamma 2 subunit, Gamma aminobutyric acid receptor pi subunit, Gamma aminobutyric acid receptor rho 2 subunit [Precursor], Gamma aminobutyric acid receptor theta subunit precursor, Gamma aminobutyric acid type A receptor alpha1 subunit, Gamma-aminobutyric acid (GABA) A receptor, rho 2, Gamma-aminobutyric acid (GABA) A receptor, subunit beta 1, Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit alpha-2, Gamma-aminobutyric acid receptor subunit alpha-3, Gamma-aminobutyric acid receptor subunit alpha-4, Gamma-aminobutyric acid receptor subunit alpha-5, Gamma-aminobutyric acid receptor subunit alpha-6, Gamma-aminobutyric acid receptor subunit beta-1, Gamma-aminobutyric acid receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit delta, Gamma-aminobutyric acid receptor subunit epsilon, Gamma-aminobutyric acid receptor subunit gamma-1, Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid receptor subunit gamma-3, Gamma-aminobutyric acid receptor subunit pi, Gamma-aminobutyric acid receptor subunit rho-1, Gamma-aminobutyric acid receptor subunit rho-2, Gamma-aminobutyric acid receptor subunit rho-3, Gamma-aminobutyric acid receptor subunit theta, Gamma-aminobutyric-acid receptor subunit beta-2, MGC116903, MGC116904, MGC126386, MGC126387, MGC163216, MGC33793, MGC45284, MGC9051, Rho 2 GABA receptor, THETA, bA135P14.1 (gamma-aminobutyric acid (GABA) receptor rho 1), gamma aminobutyric acid (GABA) receptor, theta, gamma aminobutyric acid receptor rho 1, gamma aminobutyric acid receptor, theta, gamma-aminobutyric acid (GABA) A receptor rho-1, gamma-aminobutyric acid (GABA) receptor rho 1

1 Images
Chemical Structure - Muscimol, GABAA agonist (AB120094)
  • Chemical Structure

Lab

Chemical Structure - Muscimol, GABAA agonist (AB120094)

2D chemical structure image of ab120094, Muscimol, GABAA agonist

Key facts

CAS number

2763-96-4

Purity

>99%

Form

Solid

form

Molecular weight

114.1 Da

Molecular formula

C<sub>4</sub>H<sub>6</sub>N<sub>2</sub>O<sub>2</sub>

PubChem

4266

Nature

Synthetic

Biochemical name

Muscimol

Biological description

Potent, selective GABAA agonist. Soluble in 1 ml water to give specified mM/ml concentration.

Canonical smiles

C1=C(ONC1=O)CN

InChi

InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)

InChiKey

ZJQHPWUVQPJPQT-UHFFFAOYSA-N

IUPAC Name

5-(aminomethyl)-1,2-oxazol-3-one

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Toxic, refer to SDS for further information.

Product protocols

Publications (22)

Recent publications for all applications. Explore the full list and refine your search

Proceedings of the National Academy of Sciences of the United States of America 121:e2313048121 PubMed38241439

2024

Efficient mapping of the thalamocortical monosynaptic connectivity in vivo by tangential insertions of high-density electrodes in the cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Jérémie Sibille,Carolin Gehr,Jens Kremkow

Nature 614:725-731 PubMed36755097

2023

The cellular coding of temperature in the mammalian cortex.

Applications

Unspecified application

Species

Unspecified reactive species

M Vestergaard,M Carta,G Güney,J F A Poulet

Nature communications 13:5218 PubMed36064789

2022

High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Jérémie Sibille,Carolin Gehr,Jonathan I Benichov,Hymavathy Balasubramanian,Kai Lun Teh,Tatiana Lupashina,Daniela Vallentin,Jens Kremkow

Autophagy 18:2731-2745 PubMed35311461

2022

Bidirectional regulation of structural damage on autophagy in the epidermis.

Applications

Unspecified application

Species

Unspecified reactive species

Rong Fu,Xiaowan Jiang,Yuyan Yang,Chunxia Wang,Yun Zhang,Yi Zhu,Huimin Zhang

eLife 10: PubMed33427198

2021

Lapses in perceptual decisions reflect exploration.

Applications

Unspecified application

Species

Unspecified reactive species

Sashank Pisupati,Lital Chartarifsky-Lynn,Anup Khanal,Anne K Churchland

Current biology : CB 30:3293-3303.e4 PubMed32619478

2020

Parietal Cortex Is Required for the Integration of Acoustic Evidence.

Applications

Unspecified application

Species

Unspecified reactive species

Justin D Yao,Justin Gimoto,Christine M Constantinople,Dan H Sanes

Nature communications 8:1776 PubMed29176664

2017

GABA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl-sensitive WNK1 kinase.

Applications

Unspecified application

Species

Unspecified reactive species

Martin Heubl,Jinwei Zhang,Jessica C Pressey,Sana Al Awabdh,Marianne Renner,Ferran Gomez-Castro,Imane Moutkine,Emmanuel Eugène,Marion Russeau,Kristopher T Kahle,Jean Christophe Poncer,Sabine Lévi

Cell reports 20:308-318 PubMed28700934

2017

Parvalbumin-Expressing GABAergic Neurons in Primary Motor Cortex Signal Reaching.

Applications

Unspecified application

Species

Unspecified reactive species

Luc Estebanez,Diana Hoffmann,Birgit C Voigt,James F A Poulet

Scientific reports 7:4739 PubMed28680103

2017

Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours.

Applications

Unspecified application

Species

Unspecified reactive species

Keisuke Koga,Kensho Kanehisa,Yuta Kohro,Miho Shiratori-Hayashi,Hidetoshi Tozaki-Saitoh,Kazuhide Inoue,Hidemasa Furue,Makoto Tsuda

Respiratory physiology & neurobiology 239:10-25 PubMed28137700

2017

Effects on breathing of agonists to μ-opioid or GABA receptors dialyzed into the ventral respiratory column of awake and sleeping goats.

Applications

Unspecified application

Species

Unspecified reactive species

Thomas M Langer,Suzanne E Neumueller,Emma Crumley,Nicholas J Burgraff,Sawan Talwar,Matthew R Hodges,Lawrence Pan,Hubert V Forster
View all publications

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