MW 318.24 g/mol, Purity >97%. Directly inhibits MEK, JAK1, Akt and MKK4 kinase activity. Able to inhibit cytochrome P450 3A4 and 2C9 (IC50 = 7.81 and 13.5 μM, respectively).
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Key facts
- CAS number
- 529-44-2
- Purity
- > 97%
- Form
- Solid
- Molecular weight
- 318.24 g/mol
- Molecular formula
- C15H10O8
- Nature
- Synthetic
Recommended products
MW 318.24 g/mol, Purity >97%. Directly inhibits MEK, JAK1, Akt and MKK4 kinase activity. Able to inhibit cytochrome P450 3A4 and 2C9 (IC50 = 7.81 and 13.5 μM, respectively).
.
Key facts
- CAS number
- 529-44-2
- Purity
- > 97%
- Form
- Solid
- Molecular weight
- 318.24 g/mol
- Molecular formula
- C15H10O8
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 50 mM.
- Biological description
Directly inhibits MEK, JAK1, Akt and MKK4 kinase activity. Able to inhibit cytochrome P450 3A4 and 2C9 (IC50 = 7.81 and 13.5 μM, respectively).
- IUPAC name
- 3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - Myricetin, irreversible TrxR inhibitor (ab120721)
2D chemical structure image of ab120721, Myricetin, irreversible TrxR inhibitor
Functional Studies - Myricetin, irreversible TrxR inhibitor (ab120721)
PC 12 cells were incubated at 37°C for 30 minutes with vehicle control (0 μM) and different concentrations of myricetin (ab120721). Increased expression of CaMKII (phospho T286) (Anti-CaMKII (phospho T286) antibody ab32678) in PC 12 cells correlates with an increase in myricetin concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 20 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 3% milk before being incubated with ab32678at 1/500 dilution and Anti-CaMKII antibody [EP1829Y] ab52476 at 1/500 dilution overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (Goat Anti-Rabbit IgG H&L (HRP) ab97051) at 1/10000 dilution and visualised using ECL development solution.
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