Mz1, selectively degrades BRD4

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(1 Publication)

MW 1002.6 Da, Purity >98%. Cell penetrant PROTAC (Proteolysis Targeting Chimera) compound based on (+)-JQ1 (ab141498) tethered to a von Hippel-Lindau (VHL) ligand. Retains high affinity for BRD2, BRD3 and BRD4 bromodomains. Induces preferential degradation of BRD4 over BRD2 and BRD3 in HeLa cells.

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2610203G15Rik, 2900045O07Rik, AF229032, AW108261, BRD4-NUT FUSION, BRD4-NUT fusion oncoprotein, BRD4_HUMAN, Bromodomain containing 4, Bromodomain-containing protein 4, CAP, CRBN_HUMAN, Cereblon, DDB p127 subunit, DDB1_HUMAN, DDBa, DKFZp781K0715, DNA damage-binding protein 1, DNA damage-binding protein a, Damage-specific DNA-binding protein 1, ELOB_HUMAN, ELOC_HUMAN, Elongin 15 kDa subunit, Elongin 18 kDa subunit, Elongin binding protein, Elongin-B, Elongin-C, G7 protein, HBV X-associated protein 1, HRCA 1, HUNK1, HUNKI, MCAP, MGC27358, MRT2A, Mitotic chromosome-associated protein, OTTHUMP00000209555, Protein G7, Protein HUNK1, Protein cereblon, Protein x 0001, RCA 1, RNA polymerase II transcription factor SIII p18 subunit, RNA polymerase II transcription factor SIII subunit B, RNA polymerase II transcription factor SIII subunit C, SIII, SIII p15, SIII p18, TCEB 1, TCEB 2, Transcription elongation factor B (SIII) polypeptide 1, Transcription elongation factor B (SIII) polypeptide 2, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, UV-DDB 1, UV-damaged DNA-binding factor, UV-damaged DNA-binding protein 1, VHL 1, VHLH, VHL_HUMAN, Von Hippel Lindau, Von Hippel Lindau tumor suppressor, E3 ubiquitin protein ligase, Von Hippel-Lindau disease tumor suppressor, X associated protein 1, XAP-1, XPCe, XPE, XPE-BF, XPE-binding factor, Xeroderma pigmentosum group E-complementing protein, chromosome associated protein, pVHL, piL, von Hippel Lindau syndrome, von Hippel Lindau tumor suppressor