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AB120026

N-Desmethyl clozapine (Normethylclozapine), Clozapine metabolite. M1 agonist. D2/D3 agonist.

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MW 312.8 Da, Purity >99%. Brain penetrant metabolite of the atypical antipsychotic clozapine. Broad range of actions. Potent allosteric M1 partial agonist (IC50 = 55 nM for inhibition of [3H]-NMS binding). D2/D3 partial agonist. Also displays affinity at 5-HT1 and 5-HT2.
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Chemical Structure - N-Desmethyl clozapine (Normethylclozapine), Clozapine metabolite. M1 agonist. D2/D3 agonist. (AB120026)
  • Chemical Structure

Lab

Chemical Structure - N-Desmethyl clozapine (Normethylclozapine), Clozapine metabolite. M1 agonist. D2/D3 agonist. (AB120026)

2D chemical structure image of ab120026, N-Desmethyl clozapine (Normethylclozapine), Clozapine metabolite. M1 agonist. D2/D3 agonist.

Key facts

Purity

>99%

Form

Solid

form

Molecular weight

312.8 Da

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>7</sub>ClN<sub>4</sub>

PubChem

2820

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

CID 2820

Biological description

Brain penetrant metabolite of the atypical antipsychotic clozapine. Broad range of actions. Potent allosteric M1 partial agonist (IC50 = 55 nM for inhibition of [3H]-NMS binding). D2/D3 partial agonist. Also displays affinity at 5-HT1 and 5-HT2.

Canonical smiles

C1CN(CCN1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl

Isomeric smiles

C1CN(CCN1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl

InChi

InChI=1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19,21H,7-10H2

InChiKey

HESZUPIXRNZIOI-UHFFFAOYSA-N

IUPAC Name

3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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