N-Methyl-4-phenylpyridinium Iodide (MPP+), Dopaminergic selective neurotoxin

Key facts

CAS number

36913-39-0

Purity

>98%

Form

Solid

form

Molecular weight

297.13 Da

Molecular formula

C₁₂H₁₂IN

PubChem

10924457

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

1-Methyl-4-phenylpyridinium iodide

Biological description

Dopaminergic selective neurotoxin. Active MPTP metabolite. Interferes with oxidative phosphorylation and induces mitochondrial dysfunction. Deplete cellular ATP. Shows Parkinson effects in vivo.

Canonical smiles

C[N+]1=CC=C(C=C1)C2=CC=CC=C2.[I-]

InChi

InChI=1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1

InChiKey

RFDFRDXIIKROAI-UHFFFAOYSA-M

IUPAC Name

1-methyl-4-phenylpyridin-1-ium;iodide