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AB145219

N-Palmitoyl phosphatidylethanolamine, Endogenous lipid anorectic hormone

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MW 930.4 g/mol, Purity >98%. Endogenous lipid which significantly reduced food intake in a dose-dependent fashion when administered to rats and mice without causing taste aversion. Found to enter the brain (concentrating in the hypothalamus) when administered systemically and also reduced food intake when infused intracerebroventricularly (nanomolar concentrations), suggesting that mediation of effects is via the CNS. Chronic infusion resulted in a reduction of both food intake and body weight, suggesting that NAPE and long-acting NAPE analogs may be novel therapeutic targets for the treatment of obesity.
1 Images
Chemical Structure - N-Palmitoyl phosphatidylethanolamine, Endogenous lipid anorectic hormone (AB145219)
  • Chemical Structure

Lab

Chemical Structure - N-Palmitoyl phosphatidylethanolamine, Endogenous lipid anorectic hormone (AB145219)

2D chemical structure image of ab145219, N-Palmitoyl phosphatidylethanolamine, Endogenous lipid anorectic hormone

Key facts

CAS number

108321-22-8

Purity

>98%

Molecular weight

930.4 g/mol

Molecular formula

C<sub>5</sub><sub>3</sub>H<sub>1</sub><sub>0</sub><sub>4</sub>NO<sub>9</sub>P

Nature

Synthetic

Biological description

Endogenous lipid which significantly reduced food intake in a dose-dependent fashion when administered to rats and mice without causing taste aversion. Found to enter the brain (concentrating in the hypothalamus) when administered systemically and also reduced food intake when infused intracerebroventricularly (nanomolar concentrations), suggesting that mediation of effects is via the CNS. Chronic infusion resulted in a reduction of both food intake and body weight, suggesting that NAPE and long-acting NAPE analogs may be novel therapeutic targets for the treatment of obesity.

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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