N-tert-Butyl-alpha-phenylnitrone (PBN)

Key facts

CAS number

3376-24-7

Purity

>98%

Form

Solid

form

Molecular weight

177.24 Da

Molecular formula

C₁₁H₁₅NO

PubChem

638877

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

n-Tert-butyl-alpha-phenylnitrone

Biological description

Cell permeable free radicle trap. Inhibits LPS-induced NF-κB DNA binding activity, inhibits COX-2 catalytic activity and inhibits lipid peroxidation in rat liver microsomes. Blocks indiction of iNOS by reactive oxygen species.

Canonical smiles

CC(C)(C)[N+](=CC1=CC=CC=C1)[O-]

Isomeric smiles

CC(C)(C)/[N+](=C/C1=CC=CC=C1)/[O-]

InChi

InChI=1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9-

InChiKey

IYSYLWYGCWTJSG-XFXZXTDPSA-N

IUPAC Name

N-tert-butyl-1-phenylmethanimine oxide