AB145715

N6-Methyladenosine (m6A), Modified adenosine analog

Name: N6-Methyladenosine (m6A), Modified adenosine analog (CAS 1867-73-8) | Abcam
Brand: Abcam Limited
SKU: AB145715
Price: 165 USD
Availability: InStock

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(7 Publications)

MW 281.27 g/mol, Purity >97%. Modified base. Adenosine analog methylated at the nitrogen-6 position. Abundant modification in mRNA, found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. Also found in tRNA, rRNA, and small nuclear RNA (snRNA).

1 Images

Chemical Structure - N6-Methyladenosine (m6A), Modified adenosine analog (AB145715)

Chemical Structure

Lab

Chemical Structure - N6-Methyladenosine (m6A), Modified adenosine analog (AB145715)

2D chemical structure image of ab145715, N6-Methyladenosine (m6A), Modified adenosine analog

Key facts

CAS number

1867-73-8

Purity

>97%

Form

Solid

form

Molecular weight

281.27 g/mol

Molecular formula

C11H15N5O4

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM,

Soluble in water to 25 mM

Soluble in ethanol to 5 mM

Biological description

Modified base. Adenosine analog methylated at the nitrogen-6 position. Abundant modification in mRNA, found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. Also found in tRNA, rRNA, and small nuclear RNA (snRNA).

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions|The product can be stored for up to 12 months

Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Refer to SDS for further information.

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Product protocols

Visit the General protocols
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

STAR protocols 3:101067 PubMed34901888

2021

Detection of N6-methyladenosine in SARS-CoV-2 RNA by methylated RNA immunoprecipitation sequencing.

Applications

Unspecified application

Species

Unspecified reactive species

Na Li,Tariq M Rana

STAR protocols 2:100848 PubMed34622220

2021

Protocol for preparation and measurement of intracellular and extracellular modified RNA using liquid chromatography-mass spectrometry.

Applications

Unspecified application

Species

Unspecified reactive species

Akiko Ogawa,Fan-Yan Wei

Cell reports 35:109091 PubMed33961823

2021

METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection.

Applications

Unspecified application

Species

Unspecified reactive species

Na Li,Hui Hui,Bill Bray,Gwendolyn Michelle Gonzalez,Mark Zeller,Kristian G Anderson,Rob Knight,Davey Smith,Yinsheng Wang,Aaron F Carlin,Tariq M Rana

eLife 10: PubMed33904405

2021

Widespread premature transcription termination of NLR genes by the spen protein FPA.

Applications

Unspecified application

Species

Unspecified reactive species

Matthew T Parker,Katarzyna Knop,Vasiliki Zacharaki,Anna V Sherwood,Daniel Tomé,Xuhong Yu,Pascal Gp Martin,Jim Beynon,Scott D Michaels,Geoffrey J Barton,Gordon G Simpson

Developmental cell 56:1118-1130.e6 PubMed33761320

2021

RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Hyunjoon Kim,Young-Suk Lee,Seok-Min Kim,Soohyun Jang,Hyunji Choi,Jae-Won Lee,Tae-Don Kim,V Narry Kim

Epigenetics & chromatin 13:33 PubMed32867812

2020

N-Adenosine methylation on mRNA is recognized by YTH2 domain protein of human malaria parasite Plasmodium falciparum.

Applications

Unspecified application

Species

Unspecified reactive species

Gayathri Govindaraju,Rajashekar Varma Kadumuri,Devadathan Valiyamangalath Sethumadhavan,C A Jabeena,Sreenivas Chavali,Arumugam Rajavelu

Molecular cell 75:620-630.e9 PubMed31279659

2019

PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Erdem Sendinc,David Valle-Garcia,Abhinav Dhall,Hao Chen,Telmo Henriques,Jose Navarrete-Perea,Wanqiang Sheng,Steven P Gygi,Karen Adelman,Yang Shi

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N6-Methyladenosine (m6A), Modified adenosine analog

Chemical Structure - N6-Methyladenosine (m6A), Modified adenosine analog (AB145715)

Key facts

CAS number

Purity

Form

Molecular weight

Molecular formula

Nature

Solubility

Biological description

Complementary Products

Biochemicals

Primary Antibodies

Primary Antibodies

Primary Antibodies

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Handling instructions

Product protocols

Publications (7)

Product promise