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AB120742

Nafadotride, D3 antagonist

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(3 Publications)

MW 365.5 Da, Purity >99%. Potent, selective D3 antagonist (Ki values are 0.52 nM (D3), 269 nM (D4) and 5 nM (D2)).

View Alternative Names

2700049B16Rik, 3110031N04Rik, BK channel, BK channel beta subunit, BK channel subunit beta-1, BK channel subunit beta-2, BK channel subunit beta-4, BKCA alpha, BKCA alpha subunit, BKTM, BKbeta, BKbeta1, BKbeta2, BKbeta4, CAPC, Calcium activated potassium channel beta 4 subunit, Calcium activated potassium channel subfamily M subunit beta 1, Calcium activated potassium channel subfamily M subunit beta 2, Calcium activated potassium channel subfamily M subunit beta 4, Calcium-activated potassium channel, Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel subunit beta, Calcium-activated potassium channel subunit beta-1, Calcium-activated potassium channel subunit beta-2, Calcium-activated potassium channel subunit beta-4, Charybdotoxin receptor subunit beta-1, Charybdotoxin receptor subunit beta-2, Charybdotoxin receptor subunit beta-4, Cytokeratin-associated protein in cancer, D(2) dopamine receptor, D(3) dopamine receptor, Dopamine D2 receptor, Dopamine D3 receptor, Drosophila slowpoke like, Hbeta1, Hbeta2, Hbeta3, Hbeta4, K(VCA)alpha, K(VCA)beta, K(VCA)beta-1, K(VCA)beta-2, K(VCA)beta-4, KCMA1_HUMAN, KCMB1_HUMAN, KCMB2_HUMAN, KCMB4_HUMAN, KCNMA, KCNMA1, KCNMB 1, KCNMB 2, KCa1.1, LRC26_HUMAN, Large conductance Ca2+ activated K+ channel beta 1 subunit, Large conductance Ca2+ activated K+ channel beta2 subunit, Large conductance calcium activated potassium channel beta 2 subunit, Large conductance calcium dependent potassium ion channel beta 4 subunit, Leucine-rich repeat-containing protein 26, Lrrc26, MGC22431, MGC57945, Maxi K channel, Maxi K channel beta subunit, Maxi K channel subunit beta-1, Maxi K channel subunit beta-2, Maxi K channel subunit beta-4, Maxi Potassium channel alpha, MaxiK, MaxiK channel beta 2 subunit, Potassium large conductance calcium activated channel subfamily M beta member 1, Potassium large conductance calcium activated channel subfamily M beta member 2, Potassium large conductance calcium activated channel subfamily M beta member 4, SAKCA, SLO, Slo homolog, Slo-alpha, Slo-beta, Slo-beta-1, Slo-beta-2, Slo-beta-4, Slo1, Slowpoke homolog, bA350O14.10, cytokeratin-associated protein, hSlo, hslo beta, subfamily M subunit alpha-1, subfamily M subunit beta-1, subfamily M subunit beta-2, subfamily M subunit beta-4

1 Images
Chemical Structure - Nafadotride, D3 antagonist (AB120742)
  • Chemical Structure

Lab

Chemical Structure - Nafadotride, D3 antagonist (AB120742)

2D chemical structure image of ab120742, Nafadotride, D3 antagonist

Key facts

CAS number

149649-22-9

Purity

>99%

Form

Solid

form

Molecular weight

365.5 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>2</sub><sub>7</sub>N<sub>3</sub>O<sub>2</sub>

PubChem

3408722

Nature

Synthetic

Solubility

Soluble in 1eq. HCl to 50 mM

Biochemical name

Nafadotride

Biological description

Potent, selective D3 antagonist (Ki values are 0.52 nM (D3), 269 nM (D4) and 5 nM (D2)).

Canonical smiles

CCCCN1CCCC1CNC(=O)C2=C(C3=CC=CC=C3C(=C2)C#N)OC

InChi

InChI=1S/C22H27N3O2/c1-3-4-11-25-12-7-8-17(25)15-24-22(26)20-13-16(14-23)18-9-5-6-10-19(18)21(20)27-2/h5-6,9-10,13,17H,3-4,7-8,11-12,15H2,1-2H3,(H,24,26)

InChiKey

IDZASIQMRGPBCQ-UHFFFAOYSA-N

IUPAC Name

N-[(1-butylpyrrolidin-2-yl)methyl]-4-cyano-1-methoxynaphthalene-2-carboxamide

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Product protocols

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Behavioural pharmacology 23:89-97 PubMed22157177

2011

Comparison of nafadotride, CNQX, and haloperidol on acquisition versus expression of amphetamine-conditioned place preference in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Tomek J Banasikowski,Lindsey S MacLeod,Richard J Beninger

Journal of neurophysiology 107:692-703 PubMed22049335

2011

D(2)-like dopamine receptors differentially regulate unitary IPSCs depending on presynaptic GABAergic neuron subtypes in rat nucleus accumbens shell.

Applications

Unspecified application

Species

Unspecified reactive species

Shuntaro Kohnomi,Noriaki Koshikawa,Masayuki Kobayashi

The Journal of pharmacology and experimental therapeutics 275:1239-46 PubMed8531087

1995

Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents.

Applications

Unspecified application

Species

Unspecified reactive species

F Sautel,N Griffon,P Sokoloff,J C Schwartz,C Launay,P Simon,J Costentin,A Schoenfelder,F Garrido,A Mann
View all publications

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