MW 365.5 Da, Purity >99%. Potent, selective D3 antagonist (Ki values are 0.52 nM (D3), 269 nM (D4) and 5 nM (D2)).
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- Behavioural pharmacology 23:89-972011Comparison of nafadotride, CNQX, and haloperidol on acquisition versus expression of amphetamine-conditioned place preference in rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTomek J Banasikowski,Lindsey S MacLeod,Richard J BeningerPubMed 22157177
- Journal of neurophysiology 107:692-7032011D(2)-like dopamine receptors differentially regulate unitary IPSCs depending on presynaptic GABAergic neuron subtypes in rat nucleus accumbens shell.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShuntaro Kohnomi,Noriaki Koshikawa,Masayuki KobayashiPubMed 22049335
- The Journal of pharmacology and experimental therapeutics 275:1239-461995Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents.Applications:Unspecified applicationReactive species:Unspecified reactive speciesF Sautel,N Griffon,P Sokoloff,J C Schwartz,C Launay,P Simon,J Costentin,A Schoenfelder,F Garrido,A MannPubMed 8531087
Key facts
- CAS number
- 149649-22-9
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 365.5 Da
- Molecular formula
- C22H27N3O2
- PubChem identifier
- 3408722
- Nature
- Synthetic
Target data
Alternative names
2700049B16Rik, 3110031N04Rik, BK channel, BK channel beta subunit, BK channel subunit beta-1, BK channel subunit beta-2, BK channel subunit beta-4, BKCA alpha, BKCA alpha subunit, BKTM, BKbeta, BKbeta1, BKbeta2, BKbeta4, CAPC, Calcium activated potassium channel beta 4 subunit, Calcium activated potassium channel subfamily M subunit beta 1, Calcium activated potassium channel subfamily M subunit beta 2, Calcium activated potassium channel subfamily M subunit beta 4, Calcium-activated potassium channel, Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel subunit beta, Calcium-activated potassium channel subunit beta-1, Calcium-activated potassium channel subunit beta-2, Calcium-activated potassium channel subunit beta-4, Charybdotoxin receptor subunit beta-1, Charybdotoxin receptor subunit beta-2, Charybdotoxin receptor subunit beta-4, Cytokeratin-associated protein in cancer, D(2) dopamine receptor, D(3) dopamine receptor, Dopamine D2 receptor, Dopamine D3 receptor, Drosophila slowpoke like, Hbeta1, Hbeta2, Hbeta3, Hbeta4, K(VCA)alpha, K(VCA)beta, K(VCA)beta-1, K(VCA)beta-2, K(VCA)beta-4, KCMA1_HUMAN, KCMB1_HUMAN, KCMB2_HUMAN, KCMB4_HUMAN, KCNMA, KCNMA1, KCNMB 1, KCNMB 2, KCa1.1, LRC26_HUMAN, Large conductance Ca2+ activated K+ channel beta 1 subunit, Large conductance Ca2+ activated K+ channel beta2 subunit, Large conductance calcium activated potassium channel beta 2 subunit, Large conductance calcium dependent potassium ion channel beta 4 subunit, Leucine-rich repeat-containing protein 26, Lrrc26, MGC22431, MGC57945, Maxi K channel, Maxi K channel beta subunit, Maxi K channel subunit beta-1, Maxi K channel subunit beta-2, Maxi K channel subunit beta-4, Maxi Potassium channel alpha, MaxiK, MaxiK channel beta 2 subunit, Potassium large conductance calcium activated channel subfamily M beta member 1, Potassium large conductance calcium activated channel subfamily M beta member 2, Potassium large conductance calcium activated channel subfamily M beta member 4, SAKCA, SLO, Slo homolog, Slo-alpha, Slo-beta, Slo-beta-1, Slo-beta-2, Slo-beta-4, Slo1, Slowpoke homolog, bA350O14.10, cytokeratin-associated protein, hSlo, hslo beta, subfamily M subunit alpha-1, subfamily M subunit beta-1, subfamily M subunit beta-2, subfamily M subunit beta-4
Recommended products
MW 365.5 Da, Purity >99%. Potent, selective D3 antagonist (Ki values are 0.52 nM (D3), 269 nM (D4) and 5 nM (D2)).
Key facts
- CAS number
- 149649-22-9
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 365.5 Da
- Molecular formula
- C22H27N3O2
- PubChem identifier
- 3408722
- Nature
- Synthetic
- Solubility
Soluble in 1eq. HCl to 50 mM.
- Biochemical name
- Nafadotride
- Biological description
Potent, selective D3 antagonist (Ki values are 0.52 nM (D3), 269 nM (D4) and 5 nM (D2)).
- Canonical SMILES
- CCCCN1CCCC1CNC(=O)C2=C(C3=CC=CC=C3C(=C2)C#N)OC
- InChI
- InChI=1S/C22H27N3O2/c1-3-4-11-25-12-7-8-17(25)15-24-22(26)20-13-16(14-23)18-9-5-6-10-19(18)21(20)27-2/h5-6,9-10,13,17H,3-4,7-8,11-12,15H2,1-2H3,(H,24,26)
- InChIKey
- IDZASIQMRGPBCQ-UHFFFAOYSA-N
- IUPAC name
- N-[(1-butylpyrrolidin-2-yl)methyl]-4-cyano-1-methoxynaphthalene-2-carboxamide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - Nafadotride, D3 antagonist (ab120742)
2D chemical structure image of ab120742, Nafadotride, D3 antagonist
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