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AB144489

NBQX disodium salt (mM/ml), AMPA / kainate antagonist

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(7 Publications)

MW 380.25 Da, Purity >98%. Water soluble, potent, selective and competitive AMPA/kainate receptor antagonist. Neuroprotective and anticonvulsant in vivo.
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Chemical Structure - NBQX disodium salt (mM/ml), AMPA / kainate antagonist (AB144489)
  • Chemical Structure

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Chemical Structure - NBQX disodium salt (mM/ml), AMPA / kainate antagonist (AB144489)

2D chemical structure image of ab144489, NBQX disodium salt (mM/ml), AMPA / kainate antagonist

Key facts

CAS number

479347-86-9

Purity

>98%

Form

Solid

form

Molecular weight

380.25 Da

Molecular formula

C<sub>1</sub><sub>2</sub>H<sub>6</sub>N<sub>4</sub>Na<sub>2</sub>O<sub>6</sub>S

PubChem

3272523

Nature

Synthetic

Biochemical name

6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione, Disodium Salt

Biological description

Water soluble, potent, selective and competitive AMPA/kainate receptor antagonist. Neuroprotective and anticonvulsant in vivo.

Canonical smiles

C1=CC2=C3C(=CC(=C2C(=C1)S(=O)(=O)N)[N+](=O)[O-])N=C(C(=N3)[O-])[O-].[Na+].[Na+]

InChi

InChI=1S/C12H8N4O6S.2Na/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;;/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22);;/q;2*+1/p-2

InChiKey

SVJKYIUJRJEABK-UHFFFAOYSA-L

IUPAC Name

disodium;6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-diolate

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Complementary Products

Biochemicals

AB120042

SR95531 (Gabazine), GABAA antagonist

Chemical Structure - SR95531 (Gabazine), GABAA antagonist (AB120042)

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  • 0
Biochemicals

AB120045

NBQX, AMPA / kainate antagonist

Functional Studies - NBQX, AMPA / kainate antagonist (AB120045)

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  • 0
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

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Primary Antibodies

AB32454

Anti-MAP2 antibody - Neuronal Marker

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-MAP2 antibody - Neuronal Marker (AB32454)

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  • 35
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:9259-72 PubMed23719795

2013

Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis.

Applications

Unspecified application

Species

Unspecified reactive species

Tamara Perez-Rosello,Charles T Anderson,Francisco J Schopfer,Yanjun Zhao,David Gilad,Sonia R Salvatore,Bruce A Freeman,Michal Hershfinkel,Elias Aizenman,Thanos Tzounopoulos

The Journal of neuroscience : the official journal of the Society for Neuroscience 32:6183-96 PubMed22553025

2012

Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Nicolas Narboux-Nême,Alexis Evrard,Isabelle Ferezou,Reha S Erzurumlu,Pascal S Kaeser,Jeanne Lainé,Jean Rossier,Nicole Ropert,Thomas C Südhof,Patricia Gaspar

Molecular pharmacology 78:1036-45 PubMed20837679

2010

Mapping the ligand binding sites of kainate receptors: molecular determinants of subunit-selective binding of the antagonist [3H]UBP310.

Applications

Unspecified application

Species

Unspecified reactive species

Palmi T Atlason,Caroline L Scholefield,Richard J Eaves,M Belen Mayo-Martin,David E Jane,Elek Molnár

Psychopharmacology 212:523-35 PubMed20703449

2010

On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039.

Applications

Unspecified application

Species

Unspecified reactive species

Agnieszka Pałucha-Poniewiera,Joanna M Wierońska,Piotr Brański,Katarzyna Stachowicz,Shigeyuki Chaki,Andrzej Pilc

Cerebellum (London, England) 11:121-31 PubMed20049574

2010

Calcium influx measured at single presynaptic boutons of cerebellar granule cell ascending axons and parallel fibers.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Zhang,David J Linden

The Journal of neuroscience : the official journal of the Society for Neuroscience 29:15586-94 PubMed20007482

2009

Neuromodulation at single presynaptic boutons of cerebellar parallel fibers is determined by bouton size and basal action potential-evoked Ca transient amplitude.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Zhang,David J Linden

The Journal of neuroscience : the official journal of the Society for Neuroscience 29:9930-40 PubMed19657043

2009

Early development of the thalamic inhibitory feedback loop in the primary somatosensory system of the newborn mice.

Applications

Unspecified application

Species

Unspecified reactive species

Alexis Evrard,Nicole Ropert
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