MW 380.25 Da, Purity >98%. Water soluble, potent, selective and competitive AMPA/kainate receptor antagonist. Neuroprotective and anticonvulsant in vivo.
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- The Journal of neuroscience : the official journal of the Society for Neuroscience 33:9259-722013Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTamara Perez-Rosello,Charles T Anderson,Francisco J Schopfer,Yanjun Zhao,David Gilad,Sonia R Salvatore,Bruce A Freeman,Michal Hershfinkel,Elias Aizenman,Thanos TzounopoulosPubMed 23719795
- The Journal of neuroscience : the official journal of the Society for Neuroscience 32:6183-962012Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNicolas Narboux-Nême,Alexis Evrard,Isabelle Ferezou,Reha S Erzurumlu,Pascal S Kaeser,Jeanne Lainé,Jean Rossier,Nicole Ropert,Thomas C Südhof,Patricia GasparPubMed 22553025
- Molecular pharmacology 78:1036-452010Mapping the ligand binding sites of kainate receptors: molecular determinants of subunit-selective binding of the antagonist [3H]UBP310.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPalmi T Atlason et. al.PubMed 20837679
- Psychopharmacology 212:523-352010On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAgnieszka Pałucha-Poniewiera et. al.PubMed 20703449
- Cerebellum (London, England) 11:121-312010Calcium influx measured at single presynaptic boutons of cerebellar granule cell ascending axons and parallel fibers.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWei Zhang,David J LindenPubMed 20049574
- The Journal of neuroscience : the official journal of the Society for Neuroscience 29:15586-942009Neuromodulation at single presynaptic boutons of cerebellar parallel fibers is determined by bouton size and basal action potential-evoked Ca transient amplitude.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWei Zhang,David J LindenPubMed 20007482
- The Journal of neuroscience : the official journal of the Society for Neuroscience 29:9930-402009Early development of the thalamic inhibitory feedback loop in the primary somatosensory system of the newborn mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlexis Evrard,Nicole RopertPubMed 19657043
Key facts
- CAS number
- 479347-86-9
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 380.25 Da
- Molecular formula
- C12H6N4Na2O6S
- PubChem identifier
- 3272523
- Nature
- Synthetic
Alternative names
AMPA 1, AMPA-selective glutamate receptor 1, GLUH1, GRIA1_HUMAN, GluA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor 1, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, HBGR1, MGC133252, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243
Recommended products
MW 380.25 Da, Purity >98%. Water soluble, potent, selective and competitive AMPA/kainate receptor antagonist. Neuroprotective and anticonvulsant in vivo.
Key facts
- CAS number
- 479347-86-9
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 380.25 Da
- Molecular formula
- C12H6N4Na2O6S
- PubChem identifier
- 3272523
- Nature
- Synthetic
- Biochemical name
- 6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione, Disodium Salt
- Biological description
Water soluble, potent, selective and competitive AMPA/kainate receptor antagonist. Neuroprotective and anticonvulsant in vivo.
- Canonical SMILES
- C1=CC2=C3C(=CC(=C2C(=C1)S(=O)(=O)N)[N+](=O)[O-])N=C(C(=N3)[O-])[O-].[Na+].[Na+]
- InChI
- InChI=1S/C12H8N4O6S.2Na/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;;/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22);;/q;2*+1/p-2
- InChIKey
- SVJKYIUJRJEABK-UHFFFAOYSA-L
- IUPAC name
- disodium;6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-diolate
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - NBQX disodium salt (mM/ml), AMPA / kainate antagonist (ab144489)
2D chemical structure image of ab144489, NBQX disodium salt (mM/ml), AMPA / kainate antagonist
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