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AB142131

Necrostatin-5, Necroptosis inhibitor

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MW 383.5 Da, Purity >98%. Inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase.
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Chemical Structure - Necrostatin-5, Necroptosis inhibitor (AB142131)
  • Chemical Structure

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Chemical Structure - Necrostatin-5, Necroptosis inhibitor (AB142131)

2D chemical structure image of ab142131, Necrostatin-5, Necroptosis inhibitor

Key facts

CAS number

337349-54-9

Purity

>98%

Form

Solid

form

Molecular weight

383.5 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>1</sub><sub>7</sub>N<sub>3</sub>O<sub>2</sub>S<sub>2</sub>

PubChem

1913406

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biochemical name

Necrostatin-5

Biological description

Inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase.

Canonical smiles

COC1=CC=C(C=C1)N2C(=O)C3=C(N=C2SCC#N)SC4=C3CCCC4

InChi

InChI=1S/C19H17N3O2S2/c1-24-13-8-6-12(7-9-13)22-18(23)16-14-4-2-3-5-15(14)26-17(16)21-19(22)25-11-10-20/h6-9H,2-5,11H2,1H3

InChiKey

VGONMECBFMCKBS-UHFFFAOYSA-N

IUPAC Name

2-[[3-(4-methoxyphenyl)-4-oxo-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]sulfanyl]acetonitrile

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Complementary Products

Biochemicals

AB141053

Necrostatin-1, necroptosis inhibitor

Functional Studies - Necrostatin-1, necroptosis inhibitor (AB141053)

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Biochemicals

AB143839

Necrosulfonamide, necroptosis inhibitor

Chemical Structure - Necrosulfonamide, necroptosis inhibitor (AB143839)

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Biochemicals

AB254395

GSK872, Necroptosis inhibitor

Chemical Structure - GSK872, Necroptosis inhibitor (AB254395)

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Proteins & Peptides

AB140545

Recombinant Human NRIP3 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human NRIP3 protein (His tag N-Terminus) (AB140545)

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1865 Necrostatin-5. 1865-25 is the same size as the 25 mg size of ab142131.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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Product protocols

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Product promise

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