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AB120185

Neurokinin A, Tachykinin peptide

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(1 Publication)

MW 1133.3 Da, Purity >95%. Achieve your results faster with highly validated, pure and trusted compounds.
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Functional Studies - Neurokinin A, Tachykinin peptide (AB120185)
  • FuncS

Unknown

Functional Studies - Neurokinin A, Tachykinin peptide (AB120185)

K562 cells were incubated at 37°C for 4h with vehicle control (0 μM) and 15 nM of neurokinin A (ab120185). Increased expression of p53 (ab26) correlates with an increase in neurokinin A concentration, as described in literature.

Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 20 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 3% milk before being incubated with ab26 at 5 μg/ml and ab8227 at 1 μg/ml overnight at 4°C. Antibody binding was detected using an anti-mouse antibody conjugated to HRP (ab97040) at 1/10000 dilution and visualised using ECL development solution.

Chemical Structure - Neurokinin A, Tachykinin peptide (AB120185)
  • Chemical Structure

Lab

Chemical Structure - Neurokinin A, Tachykinin peptide (AB120185)

2D chemical structure image of ab120185, Neurokinin A, Tachykinin peptide

Key facts

CAS number

86933-74-6

Purity

>95%

Form

Solid

form

Molecular weight

1133.3 Da

Molecular formula

C<sub>5</sub><sub>0</sub>H<sub>8</sub><sub>0</sub>N<sub>1</sub><sub>4</sub>O<sub>1</sub><sub>4</sub>S

PubChem

55582

Nature

Synthetic

Solubility

Soluble in water

Biochemical name

alpha-Neurokinin;Neuromedin L;Substance K

Canonical smiles

CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N

InChi

InChI=1S/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69)

InChiKey

HEAUFJZALFKPBA-UHFFFAOYSA-N

IUPAC Name

3-[[2-[[6-amino-2-[[2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]-3-hydroxybutanoyl]amino]-4-[[1-[[1-[[1-[[2-[[1-[(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of pharmacology and experimental thera 375:28-39 PubMed32764152

2020

Gender-Related Differences of Tachykinin NK Receptor Expression and Activity in Human Colonic Smooth Muscle.

Applications

Unspecified application

Species

Unspecified reactive species

Stelina Drimousis,Irit Markus,Tim V Murphy,D Shevy Perera,Kim-Chi Phan-Thien,Li Zhang,Lu Liu
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