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AB145954

NF-kappaB Activation Inhibitor VI, benzoxathiole compound

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(7 Publications)

MW 273.4 Da, Purity >95%. Cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser177 and/or Ser181 residues in the kinase's activation loop domain. Shown to inhibit LPS-induced NF-κB activation (IC50 = 1.0 μM) and nitrite production (IC50 = 0.7 μM) in RAW 264.7 cells in vitro and effectively prevent LPS-induced septic death in mice in vivo.
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Chemical Structure - NF-kappaB Activation Inhibitor VI, benzoxathiole compound (AB145954)
  • Chemical Structure

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Chemical Structure - NF-kappaB Activation Inhibitor VI, benzoxathiole compound (AB145954)

2D chemical structure image of ab145954, NF-kappaB Activation Inhibitor VI, benzoxathiole compound

Key facts

CAS number

113760-29-5

Purity

>95%

Form

Solid

form

Molecular weight

273.4 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>5</sub>NO<sub>2</sub>S

PubChem

13925917

Nature

Synthetic

Solubility

Soluble in DMSO

Soluble in ethanol

Biochemical name

1,3-Benzoxathiol-4(5H)-one, 6,7-dihydro-6,6-dimethyl-2-(phenylimino)-

Biological description

Cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser177 and/or Ser181 residues in the kinase's activation loop domain. Shown to inhibit LPS-induced NF-κB activation (IC50 = 1.0 μM) and nitrite production (IC50 = 0.7 μM) in RAW 264.7 cells in vitro and effectively prevent LPS-induced septic death in mice in vivo.

Canonical smiles

CC1(CC2=C(C(=O)C1)SC(=NC3=CC=CC=C3)O2)C

InChi

InChI=1S/C15H15NO2S/c1-15(2)8-11(17)13-12(9-15)18-14(19-13)16-10-6-4-3-5-7-10/h3-7H,8-9H2,1-2H3

InChiKey

XFSSJIQCIPSBHJ-UHFFFAOYSA-N

IUPAC Name

6,6-dimethyl-2-phenylimino-5,7-dihydro-1,3-benzoxathiol-4-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine (Cambridge, Mass.) 30:106 PubMed39039432

2024

Modulating the RPS27A/PSMD12/NF-κB pathway to control immune response in mouse brain ischemia-reperfusion injury.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaocheng Li,Ming Qiao,Yan Zhou,Yan Peng,Gang Wen,Chenchen Xie,Yamei Zhang

Cancer letters 587:216724 PubMed38373689

2024

CD24 negativity reprograms mitochondrial metabolism to PPARα and NF-κB-driven fatty acid β-oxidation in triple-negative breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Divya Murthy,Debasmita Dutta,Kuldeep S Attri,Tagari Samanta,Sukjin Yang,Kwang Hwa Jung,Sarah G Latario,Vasanta Putluri,Shixia Huang,Nagireddy Putluri,Jun Hyoung Park,Benny Abraham Kaipparettu

Science advances 8:eabo4662 PubMed36170369

2022

Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Gwyneth M Welch,Carles A Boix,Eloi Schmauch,Jose Davila-Velderrain,Matheus B Victor,Vishnu Dileep,P Lorenzo Bozzelli,Qiao Su,Jemmie D Cheng,Audrey Lee,Noelle S Leary,Andreas R Pfenning,Manolis Kellis,Li-Huei Tsai

Nature immunology 23:386-398 PubMed35190717

2022

Tcf1 preprograms the mobilization of glycolysis in central memory CD8 T cells during recall responses.

Applications

Unspecified application

Species

Unspecified reactive species

Qiang Shan,Shengen Shawn Hu,Shaoqi Zhu,Xia Chen,Vladimir P Badovinac,Weiqun Peng,Chongzhi Zang,Hai-Hui Xue

Chemical biology & drug design 97:1151-1157 PubMed33638265

2021

Toll-like receptor 4 antagonist FP7 alleviates lipopolysaccharide-induced septic shock via NF-kB signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Li,Junhui Wang,Mailiang Zhao,Sheng Zhang,Yanwei Zhang

Aging 12: PubMed33495418

2021

Resveratrol alleviates bleomycin-induced pulmonary fibrosis via suppressing HIF-1α and NF-κB expression.

Applications

Unspecified application

Species

Unspecified reactive species

Zaiyan Wang,Xiaoning Li,Hao Chen,Li Han,Xiaobin Ji,Qiubo Wang,Li Wei,Yafang Miu,Jing Wang,Jianfeng Mao,Zeming Zhang

International journal of molecular sciences 21: PubMed32575834

2020

Secretome of Hypoxic Endothelial Cells Stimulates Bone Marrow-Derived Mesenchymal Stem Cells to Enhance Alternative Activation of Macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Kang-Ju Chou,Chih-Yang Hsu,Chien-Wei Huang,Hsin-Yu Chen,Shih-Hsiang Ou,Chien-Liang Chen,Po-Tsang Lee,Hua-Chang Fang
View all publications
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