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AB120137

NG-Monomethyl-L-arginine, monoacetate salt (L-NMMA), NOS inhibitor

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(8 Publications)

NG-Monomethyl-L-arginine, monoacetate salt (L-NMMA) (CAS: 53308-83-1)(ab120137) is a cell-permeable competitive NOS inhibitor. (Ki values are 700 nM, 3.9 µM and 650 nM for eNOS, iNOS and nNOS, respectively). MW 248.28, Purity >98%.

- Available in different formats to fit your experimental needs. Larger volume format available upon request.
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Chemical Structure - NG-Monomethyl-L-arginine, monoacetate salt (L-NMMA), NOS inhibitor (AB120137)
  • Chemical Structure

Lab

Chemical Structure - NG-Monomethyl-L-arginine, monoacetate salt (L-NMMA), NOS inhibitor (AB120137)

2D chemical structure image of ab120137, NG-Monomethyl-L-arginine, monoacetate salt (L-NMMA), NOS inhibitor

Key facts

CAS number

53308-83-1

Purity

>98%

Form

Solid

form

Molecular weight

248.28 Da

Molecular formula

C<sub>9</sub>H<sub>2</sub><sub>0</sub>N<sub>4</sub>O<sub>4</sub>

PubChem

135242

Nature

Synthetic

Solubility

Soluble in water to 50 mM

Biochemical name

Tilarginine Acetate

Biological description

Cell-permeable competitive NOS inhibitor. (Ki values are 700 nM, 3.9 μM and 650 nM for eNOS, iNOS and nNOS, respectively).

Canonical smiles

CC(=O)O.CN=C(N)NCCCC(C(=O)O)N

Isomeric smiles

CC(=O)O.CN=C(N)NCCC[C@@H](C(=O)O)N

InChi

InChI=1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1

InChiKey

IKPNWIGTWUZCKM-JEDNCBNOSA-N

IUPAC Name

acetic acid;(2S)-2-amino-5-[(N'-methylcarbamimidoyl)amino]pentanoic acid

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Complementary Products

Biochemicals

AB120136

N omega-Nitro-L-arginine methyl ester hydrochloride (L-NAME), NOS inhibitor

Chemical Structure - N omega-Nitro-L-arginine methyl ester hydrochloride (L-NAME), NOS inhibitor (AB120136)

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Assay Kits

AB65328

Nitric Oxide Assay Kit (Colorimetric)

Functional Studies - Nitric Oxide Assay Kit (Colorimetric) (AB65328)

  • 4
  • 2
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Assay Kits

AB65327

Nitric Oxide Assay Kit (Fluorometric)

Functional Studies - Nitric Oxide Assay Kit (Fluorometric) (AB65327)

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  • 0
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 42:6211-6220 PubMed35790402

2022

Induction of Activity-Dependent Plasticity at Auditory Nerve Synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Nicole F Wong,Matthew A Xu-Friedman

Frontiers in molecular neuroscience 13:56 PubMed32317932

2020

Nystatin Regulates Axonal Extension and Regeneration by Modifying the Levels of Nitric Oxide.

Applications

Unspecified application

Species

Unspecified reactive species

Cristina Roselló-Busquets,Marc Hernaiz-Llorens,Eduardo Soriano,Ramon Martínez-Mármol

Pflugers Archiv : European journal of physiology 472:61-74 PubMed31822999

2019

Neuronal nitric oxide synthase regulation of calcium cycling in ventricular cardiomyocytes is independent of Ca1.2 channel modulation under basal conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Janine Ebner,Michal Cagalinec,Helmut Kubista,Hannes Todt,Petra L Szabo,Attila Kiss,Bruno K Podesser,Henrietta Cserne Szappanos,Livia C Hool,Karlheinz Hilber,Xaver Koenig

Atherosclerosis 287:70-80 PubMed31229835

2019

CD13 deficiency leads to increased oxidative stress and larger atherosclerotic lesions.

Applications

Unspecified application

Species

Unspecified reactive species

Charan V Devarakonda,Flavia E Pereira,Jonathan D Smith,Linda H Shapiro,Mallika Ghosh

Biomolecules & therapeutics 25:519-527 PubMed28554197

2017

A New Neolignan Derivative, Balanophonin Isolated from Delays the Progress of Neuronal Cell Death by Inhibiting Microglial Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Soo Young Lim,Lalita Subedi,Dongyun Shin,Chung Sub Kim,Kang Ro Lee,Sun Yeou Kim

Nature medicine 22:146-53 PubMed26779811

2016

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease.

Applications

Unspecified application

Species

Unspecified reactive species

Christian Lood,Luz P Blanco,Monica M Purmalek,Carmelo Carmona-Rivera,Suk S De Ravin,Carolyne K Smith,Harry L Malech,Jeffrey A Ledbetter,Keith B Elkon,Mariana J Kaplan

Journal of immunology (Baltimore, Md. : 1950) 192:3068-79 PubMed24567529

2014

Targeting S1P1 receptor protects against murine immunological hepatic injury through myeloid-derived suppressor cells.

Applications

Unspecified application

Species

Unspecified reactive species

Guangwei Liu,Yujing Bi,Ruoning Wang,Hui Yang,Yan Zhang,Xiao Wang,Huanrong Liu,Yun Lu,Zhengguo Zhang,Wanna Chen,Yiwei Chu,Ruifu Yang

The Journal of physiology 591:3309-24 PubMed23613534

2013

Calcium channels in rat horizontal cells regulate feedback inhibition of photoreceptors through an unconventional GABA- and pH-sensitive mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Xue Liu,Arlene A Hirano,Xiaoping Sun,Nicholas C Brecha,Steven Barnes
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