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AB145188

NH 125, CaMK III inhibitor

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MW 524.6 Da, Purity >99%. Potent, selective CaMK III inhibitor (IC50 = 60 nM). Histidine protein kinase inhibitor (IC50 = 6.6 μM). Induces G1/S cell cycle arrest and apoptosis. Shows anticancer effects. Antibacterial agent in vivo. .
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Chemical Structure - NH 125, CaMK III inhibitor (AB145188)
  • Chemical Structure

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Chemical Structure - NH 125, CaMK III inhibitor (AB145188)

2D chemical structure image of ab145188, NH 125, CaMK III inhibitor

Key facts

CAS number

278603-08-0

Purity

>99%

Form

Solid

form

Molecular weight

524.6 Da

Molecular formula

C<sub>2</sub><sub>7</sub>H<sub>4</sub><sub>5</sub>IN<sub>2</sub>

PubChem

10436839

Nature

Synthetic

Solubility

Soluble in ethanol to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

1-Benzyl-3-cetyl-2-methylimidazolium iodide

Biological description

Potent, selective CaMK III inhibitor (IC50 = 60 nM). Histidine protein kinase inhibitor (IC50 = 6.6 μM). Induces G1/S cell cycle arrest and apoptosis. Shows anticancer effects. Antibacterial agent in vivo.

Canonical smiles

CCCCCCCCCCCCCCCCN1C=C[N+](=C1C)CC2=CC=CC=C2.[I-]

InChi

InChI=1S/C27H45N2.HI/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-28-23-24-29(26(28)2)25-27-20-17-16-18-21-27;/h16-18,20-21,23-24H,3-15,19,22,25H2,1-2H3;1H/q+1;/p-1

InChiKey

RVWOHCBHAGBLLT-UHFFFAOYSA-M

IUPAC Name

1-benzyl-3-hexadecyl-2-methylimidazol-1-ium;iodide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
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Product protocols

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Complementary Products

Biochemicals

AB120421

KN-62, CaM kinase II inhibitor. P2X7 antagonist.

Immunocytochemistry/ Immunofluorescence - KN-62, CaM kinase II inhibitor. P2X7 antagonist. (AB120421)

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Biochemicals

AB120980

KN-93 (water soluble), CaMK II inhibitor

Immunocytochemistry/ Immunofluorescence - KN-93 (water soluble), CaMK II inhibitor (AB120980)

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Primary Antibodies

AB124880

Anti-CaMKII alpha (phospho T286) antibody [EPR1830]

BOND RX™ Validated|RabMAb|Recombinant|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CaMKII alpha (phospho T286) antibody [EPR1830] (AB124880)

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Primary Antibodies

AB181052

Anti-CaMKII delta antibody [EPR13095]

KO Validated|RabMAb|Recombinant

Western blot - Anti-CaMKII delta antibody [EPR13095] (AB181052)

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