MW 346.3 Da, Purity >99%. L-type Ca2+ channel blocker. Potent, long-acting vasodilator. Also shown to inhibit vascular inflammation.
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- iScience 25:1044362022Phototransduction in a marine sponge provides insights into the origin of animal vision.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEunice Wong,Victor Anggono,Stephen R Williams,Sandie M Degnan,Bernard M DegnanPubMed 35707725
- Frontiers in cellular neuroscience 13:5692020Allopregnanolone Modulates GABAAR-Dependent CaMKIIδ3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTongtong Wang,Xin Ye,Wei Bian,Zhichi Chen,Juanjuan Du,Mengyi Li,Peng Zhou,Huairui Cui,Yu-Qiang Ding,Shuangshuang Qi,Min Liao,Chenyou SunPubMed 31998078
- Scientific reports 7:93572017Optogenetic regulation of insulin secretion in pancreatic β-cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFan Zhang,Emmanuel S TzanakakisPubMed 28839233
- Neuron 95:639-655.e102017Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEmilia Favuzzi et. al.PubMed 28712654
- Molecular biology of the cell 27:3329-33412016Regulation of Ca2+ channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clusters.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTrine Lisberg Toft-Bertelsen et. al.PubMed 27605709
- Neurobiology of aging 36:730-92014Rescue of impaired late-phase long-term depression in a tau transgenic mouse model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTariq Ahmed,David Blum,Sylvie Burnouf,Dominique Demeyer,Valérie Buée-Scherrer,Rudi D'Hooge,Luc Buée,Detlef BalschunPubMed 25443285
- The Journal of physiology 592:3537-572014Depression biased non-Hebbian spike-timing-dependent synaptic plasticity in the rat subiculum.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnurag Pandey,Sujit Kumar SikdarPubMed 24907304
- Proceedings of the National Academy of Sciences of 111:4303-82014Mossy fiber-evoked subthreshold responses induce timing-dependent plasticity at hippocampal CA3 recurrent synapses.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFederico Brandalise et. al.PubMed 24550458
- Journal of neurophysiology 110:1535-432013Identification of CaV channel types expressed in muscle afferent neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRenuka Ramachandra et. al.PubMed 23843437
- The Journal of general physiology 141:165-782013Ca2+ oscillations, Ca2+ sensitization, and contraction activated by protein kinase C in small airway smooth muscle.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSeema Mukherjee,Jacquelyn Trice,Paurvi Shinde,Ray E Willis,Thomas A Pressley,Jose F Perez-ZoghbiPubMed 23359281
Key facts
- CAS number
- 21829-25-4
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 346.3 Da
- Molecular formula
- C17H18N2O6
- PubChem identifier
- 4485
- Nature
- Synthetic
Target data
Recommended products
MW 346.3 Da, Purity >99%. L-type Ca2+ channel blocker. Potent, long-acting vasodilator. Also shown to inhibit vascular inflammation.
Key facts
- CAS number
- 21829-25-4
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 346.3 Da
- Molecular formula
- C17H18N2O6
- PubChem identifier
- 4485
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biochemical name
- Nifedipine
- Biological description
L-type Ca2+ channel blocker. Potent, long-acting vasodilator. Also shown to inhibit vascular inflammation.
- Canonical SMILES
- CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
- InChI
- InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
- InChIKey
- HYIMSNHJOBLJNT-UHFFFAOYSA-N
- IUPAC name
- dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - Nifedipine, L-type Ca2+ channel blocker (ab120135)
2D chemical structure image of ab120135, Nifedipine, L-type Ca2+ channel blocker
Functional Studies - Nifedipine, L-type Ca2+ channel blocker (ab120135)
ab2770 staining aryl hydrocarbon receptor in MDA-MB-231 cells treated with nifedipine (ab120135), by ICC/IF. Increase in aryl hydrocarbon receptor expression correlates with increased concentration of nifedipine, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120135 (nifedipine) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab2770 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (Goat Anti-Mouse IgG H&L (DyLight® 488) preadsorbed ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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