AB120135

Nifedipine, L-type Ca2+ channel blocker

Name: Nifedipine, L-type Ca2+ channel blocker (CAS 21829-25-4) | Abcam
Brand: Abcam Limited
SKU: AB120135
Price: 55 USD
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(14 Publications)

MW 346.3 Da, Purity >99%. L-type Ca2+ channel blocker. Potent, long-acting vasodilator. Also shown to inhibit vascular inflammation.

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Functional Studies - Nifedipine, L-type Ca2+ channel blocker (AB120135)

FuncS

Unknown

Functional Studies - Nifedipine, L-type Ca2+ channel blocker (AB120135)

ab2770 staining aryl hydrocarbon receptor in MDA-MB-231 cells treated with nifedipine (ab120135), by ICC/IF. Increase in aryl hydrocarbon receptor expression correlates with increased concentration of nifedipine, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120135 (nifedipine) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab2770 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight^® 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Nifedipine, L-type Ca2+ channel blocker (AB120135)

Chemical Structure

Lab

Chemical Structure - Nifedipine, L-type Ca2+ channel blocker (AB120135)

2D chemical structure image of ab120135, Nifedipine, L-type Ca2+ channel blocker

Key facts

CAS number

21829-25-4

Purity

>99%

Form

Solid

form

Molecular weight

346.3 Da

Molecular formula

C17H18N2O6

PubChem

4485

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Nifedipine

Biological description

L-type Ca2+ channel blocker. Potent, long-acting vasodilator. Also shown to inhibit vascular inflammation.

Canonical smiles

CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC

InChi

InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3

InChiKey

HYIMSNHJOBLJNT-UHFFFAOYSA-N

IUPAC Name

dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Store under desiccating conditions|The product can be stored for up to 12 months

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Product protocols

Visit the General protocols
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Publications (14)

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ACS pharmacology & translational science 7:236-248 PubMed38230281

2024

Optogenetic Activation of Peripheral Somatosensory Neurons in Transgenic Mice as a Neuropathic Pain Model for Assessing the Therapeutic Efficacy of Analgesics.

Applications

Unspecified application

Species

Unspecified reactive species

Hao-Hao Chen,Muhammad Mohsin,Jia-Yi Ge,Yu-Ting Feng,Jing-Ge Wang,Yu-Sen Ou,Zuo-Jie Jiang,Bo-Ya Hu,Xing-Jun Liu

Cell stem cell 30:86-95.e4 PubMed36563695

2022

A deep learning platform to assess drug proarrhythmia risk.

Applications

Unspecified application

Species

Unspecified reactive species

Ricardo Serrano,Dries A M Feyen,Arne A N Bruyneel,Anna P Hnatiuk,Michelle M Vu,Prashila L Amatya,Isaac Perea-Gil,Maricela Prado,Timon Seeger,Joseph C Wu,Ioannis Karakikes,Mark Mercola

iScience 25:104436 PubMed35707725

2022

Phototransduction in a marine sponge provides insights into the origin of animal vision.

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Unspecified application

Species

Unspecified reactive species

Eunice Wong,Victor Anggono,Stephen R Williams,Sandie M Degnan,Bernard M Degnan

Frontiers in cellular neuroscience 13:569 PubMed31998078

2020

Allopregnanolone Modulates GABAAR-Dependent CaMKIIδ3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage.

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Unspecified application

Species

Unspecified reactive species

Tongtong Wang,Xin Ye,Wei Bian,Zhichi Chen,Juanjuan Du,Mengyi Li,Peng Zhou,Huairui Cui,Yu-Qiang Ding,Shuangshuang Qi,Min Liao,Chenyou Sun

Scientific reports 7:9357 PubMed28839233

2017

Optogenetic regulation of insulin secretion in pancreatic β-cells.

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Unspecified application

Species

Unspecified reactive species

Fan Zhang,Emmanuel S Tzanakakis

Neuron 95:639-655.e10 PubMed28712654

2017

Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican.

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Unspecified application

Species

Unspecified reactive species

Emilia Favuzzi,André Marques-Smith,Rubén Deogracias,Christian M Winterflood,Alberto Sánchez-Aguilera,Laura Mantoan,Patricia Maeso,Cathy Fernandes,Helge Ewers,Beatriz Rico

Molecular biology of the cell 27:3329-3341 PubMed27605709

2016

Regulation of Ca2+ channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clusters.

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Unspecified application

Species

Unspecified reactive species

Trine Lisberg Toft-Bertelsen,Iwona Ziomkiewicz,Sébastien Houy,Paulo S Pinheiro,Jakob B Sørensen

Neurobiology of aging 36:730-9 PubMed25443285

2014

Rescue of impaired late-phase long-term depression in a tau transgenic mouse model.

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Unspecified application

Species

Unspecified reactive species

Tariq Ahmed,David Blum,Sylvie Burnouf,Dominique Demeyer,Valérie Buée-Scherrer,Rudi D'Hooge,Luc Buée,Detlef Balschun

The Journal of physiology 592:3537-57 PubMed24907304

2014

Depression biased non-Hebbian spike-timing-dependent synaptic plasticity in the rat subiculum.

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Unspecified application

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Unspecified reactive species

Anurag Pandey,Sujit Kumar Sikdar

Proceedings of the National Academy of Sciences of 111:4303-8 PubMed24550458

2014

Mossy fiber-evoked subthreshold responses induce timing-dependent plasticity at hippocampal CA3 recurrent synapses.

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Unspecified application

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Unspecified reactive species

Federico Brandalise,Urs Gerber

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Nifedipine, L-type Ca2+ channel blocker

Functional Studies - Nifedipine, L-type Ca2+ channel blocker (AB120135)

Chemical Structure - Nifedipine, L-type Ca2+ channel blocker (AB120135)

Key facts

CAS number

Purity

Form

Molecular weight

Molecular formula

PubChem

Nature

Solubility

Biochemical name

Biological description

Canonical smiles

InChi

InChiKey

IUPAC Name

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Publications (14)

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Biochemicals

Biochemicals

Biochemicals

Primary Antibodies

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