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MW 275.22 g/mol, Purity >98%. JAK/STAT signaling inhibitor. Nitrofuran antibiotic. Inhibits JAK2 and Tyk2 phosphorylation and subsequent downstream STAT3 inhibition (EC50 = 3 μM). Antidiarrheal. Shows little effect on Akt, NF-κB, JAK1, MAPK and Src signaling.

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Images

Chemical Structure - Nifuroxazide, JAK/STAT signaling inhibitor (AB120951), expandable thumbnail
  • Functional Studies - Nifuroxazide, JAK/STAT signaling inhibitor (AB120951), expandable thumbnail

Key facts

CAS number
965-52-6
Purity
> 98%
Form
Solid
Molecular weight
275.22 g/mol
Molecular formula
C12H9N3O5
Nature
Synthetic

Target data

Recommended products

MW 275.22 g/mol, Purity >98%. JAK/STAT signaling inhibitor. Nitrofuran antibiotic. Inhibits JAK2 and Tyk2 phosphorylation and subsequent downstream STAT3 inhibition (EC50 = 3 μM). Antidiarrheal. Shows little effect on Akt, NF-κB, JAK1, MAPK and Src signaling.

Key facts

Purity
> 98%
Solubility

Soluble in DMSO to 100 mM.

Biological description

JAK/STAT signaling inhibitor. Nitrofuran antibiotic. Inhibits JAK2 and Tyk2 phosphorylation and subsequent downstream STAT3 inhibition (EC50 = 3 μM). Antidiarrheal. Shows little effect on Akt, NF-κB, JAK1, MAPK and Src signaling.

IUPAC name
4-Hydroxybenzoic acid 2-[(5-nitro-2-furanyl)methylene]hydrazide

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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2 product images

  • Chemical Structure - Nifuroxazide, JAK/STAT signaling inhibitor (ab120951), expandable thumbnail

    Chemical Structure - Nifuroxazide, JAK/STAT signaling inhibitor (ab120951)

    2D chemical structure image of ab120951, Nifuroxazide, JAK/STAT signaling inhibitor

  • Functional Studies - Nifuroxazide, JAK/STAT signaling inhibitor (ab120951), expandable thumbnail

    Functional Studies - Nifuroxazide, JAK/STAT signaling inhibitor (ab120951)

    FOX-NY cells were incubated at 37°C for 30 minutes with vehicle control (0 μM) and different concentrations of nifuroxazide (ab120951). Decreased expression of Stat3 (phospho Y705) (Anti-STAT3 (phospho Y705) antibody [EP2147Y] ab76315) in FOX-NY cells correlates with an increase in nifuroxazide concentration, as described in literature.

    Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 20 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with Anti-STAT3 (phospho Y705) antibody [EP2147Y] ab76315 at 1/20000 dilution and Anti-beta Actin antibody ab8227 at 1 μg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (Goat Anti-Rabbit IgG H&L (HRP) ab97051) at 1/10000 dilution and visualised using ECL development solution.

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