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AB146147

NKY 80, adenylyl cyclase 5 inhibitor

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MW 229.23 Da. Selective adenylyl cyclase 5 inhibitor (IC50 values are 8, 132 and 1700 μM for AC5, AC3 and AC2 respectively). Cell-permeable. Non-competitive with ATP and forskolin. Regulates AC catalytic activity in heart and lung tissues ex vivo. .
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Chemical Structure - NKY 80, adenylyl cyclase 5 inhibitor (AB146147)
  • Chemical Structure

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Chemical Structure - NKY 80, adenylyl cyclase 5 inhibitor (AB146147)

2D chemical structure image of ab146147, NKY 80, adenylyl cyclase 5 inhibitor

Key facts

CAS number

299442-43-6

Form

Solid

form

Molecular weight

229.23 Da

Molecular formula

C<sub>1</sub><sub>2</sub>H<sub>1</sub><sub>1</sub>N<sub>3</sub>O<sub>2</sub>

PubChem

2772368

Nature

Synthetic

Solubility

Soluble in ethanol to 10 mM (with warming)

Soluble in DMSO to 100 mM

Biochemical name

2-Amino-7-furan-2-yl-7,8-dihydro-6H-quinazolin-5-one

Biological description

Selective adenylyl cyclase 5 inhibitor (IC50 values are 8, 132 and 1700 μM for AC5, AC3 and AC2 respectively). Cell-permeable. Non-competitive with ATP and forskolin. Regulates AC catalytic activity in heart and lung tissues ex vivo.

Canonical smiles

C1C(CC(=O)C2=CN=C(N=C21)N)C3=CC=CO3

InChi

InChI=1S/C12H11N3O2/c13-12-14-6-8-9(15-12)4-7(5-10(8)16)11-2-1-3-17-11/h1-3,6-7H,4-5H2,(H2,13,14,15)

InChiKey

SOJUSNIBPPMLCC-UHFFFAOYSA-N

IUPAC Name

2-amino-7-(furan-2-yl)-7,8-dihydro-6H-quinazolin-5-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Toxic, refer to SDS for further information.

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Product protocols

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Product promise

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