MW 147.13 Da, Purity >99%. Excitotoxic amino acid. Prototypic agonist at the ionotropic NMDA glutamate receptor which is involved in long-term potentiation, ischemia, and epilepsy.
AMPA 1, AMPA-selective glutamate receptor 1, AW490526, CHNG1, EB11, EC 3.4.21., EIEE27, EPND, FESD, GLUH1, GRIA1_HUMAN, GRIN 2A, GRIN 2B, GRIN3A, GRIN3B, GluA1, GluN1, GluN2A, GluN2C, GluN2D, GluR-1, GluR-A, GluR-K1, Glutamate Receptor Ionotropic N Methyl D Aspartate 2B, Glutamate Receptor Ionotropic N Methyl D Aspartate 2C, Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B, Glutamate Receptor Ionotropic N methyl D aspartate 3A, Glutamate [NMDA] receptor subunit epsilon-1, Glutamate [NMDA] receptor subunit epsilon-2, Glutamate [NMDA] receptor subunit epsilon-3, Glutamate [NMDA] receptor subunit epsilon-4, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor, Glutamate receptor 1, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, Glutamate receptor ionotropic N methyl D aspartate 1, Glutamate receptor ionotropic N methyl D aspartate 2A, Glutamate receptor ionotropic N methyl D aspartate 3B, Glutamate receptor ionotropic NMDA2B, Glutamate receptor ionotropic, N-methyl-D aspartate, subunit 1, Glutamate receptor ionotropic, NMDA 2C, Glutamate receptor subunit epsilon 2, Glutamate receptor, ionotropic, N-methyl D-aspartate 2D, Glutamate receptor, ionotropic, NMDA2B (epsilon 2), Grin2c, Grin2d, HBGR1, HEPS_HUMAN, Hepsin, Hpn, LGR 3, LKS, MGC133252, MGC142178, MGC142180, MGC75129, MRD6, MRD8, N Methly D Aspartate Receptor Channel Subunit Epsilon 3, N methyl D asparate receptor channel subunit epsilon 2, N methyl D aspartate receptor channel subunit zeta 1, N methyl D aspartate receptor channel, subunit epsilon 1, N methyl D aspartate receptor subunit 2A, N methyl D aspartate receptor subunit 2B, N methyl D aspartate receptor subunit 2C, N methyl d aspartate receptor subunit 2D, N-methyl D-aspartate receptor subtype 2A, N-methyl D-aspartate receptor subtype 2B, N-methyl D-aspartate receptor subtype 2C, N-methyl D-aspartate receptor subtype 2D, N-methyl-D-aspartate receptor, N-methyl-D-aspartate receptor subunit 3, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, NMDA 1, NMDA 2D, NMDA NR2B, NMDA receptor 1, NMDA receptor subtype 2A, NMDA receptor subunit 3A, NMDA receptor subunit 3B, NMDAR, NMDAR2C, NMDAR2D, NMDE1_HUMAN, NMDE2_HUMAN, NMDE3_HUMAN, NMDE4_HUMAN, NMDZ1_HUMAN, NR1, NR2A, NR2B, NR2C, NR2D, NR3, OTTHUMP00000041930, OTTHUMP00000160135, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000174531, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243, Serine protease hepsin, Serine protease hepsin catalytic chain, Serine protease hepsin non catalytic chain, Seven transmembrane helix receptor, TMPRSS 1, TSH Receptor, TSHR_HUMAN, Thyroid adenoma hyperfunctioning, Thyroid carcinoma with thyrotoxicosis, Thyroid stimulating hormone receptor, isoform 2, Thyroid-stimulating hormone receptor, Thyrotropin receptor, Thyrotropin receptor I, Thyrotropin receptor I, hTSHR I, Transmembrane protease serine 1, estrogen receptor binding CpG island, glutamate receptor ionotropic NMDA 2D, glutamate receptor ionotropic, NMDA 1, hNR 3, hNR2A, hTSHR I
MW 147.13 Da, Purity >99%. Excitotoxic amino acid. Prototypic agonist at the ionotropic NMDA glutamate receptor which is involved in long-term potentiation, ischemia, and epilepsy.
Excitotoxic amino acid. Prototypic agonist at the ionotropic NMDA glutamate receptor which is involved in long-term potentiation, ischemia, and epilepsy.
The NMDAR family including subunits like NMDAR2A NMDAR2B (also known as GluN2B) GluN2C and GluN2D forms parts of the NMDA receptor complex critical for synaptic transmission and plasticity in the central nervous system. NMDAR1 (or GluN1) provides the obligatory subunit for functional receptor formation. NMDAR3A and 3B lesser-known components also contribute differentially to receptor composition and function. These receptors are expressed widely across the brain impacting processes like learning and memory. The thyroid-stimulating hormone receptor (TSH-R) with a mass around 84 kDa is important for thyroid gland function and is expressed in thyroid tissues. Hepsin (HPN) a serine protease found abundantly in liver and kidney tissues plays roles in cell growth and tissue homeostasis.
The NMDA receptors integrated into a complex modify neuroplasticity and excitatory synaptic transmission. The receptor requires both ligand binding and voltage change for activation ensuring precise calcium ion flux modulation. The TSH receptor engages in the regulation of thyroid hormones influencing metabolism. Hepsin facilitates cellular processes such as proteolysis during tissue remodeling. These proteins by modulating neurotransmission or endocrine signaling have roles in maintaining cellular function and systemic balance.
NMDA receptors participate critical roles in the glutamatergic signaling pathway impacting synapse formation and synaptic plasticity. Their interaction with other synaptic proteins like PSD-95 illustrates their involvement in neurodevelopment. The TSH receptor activates the cAMP signaling pathway which manages metabolic activities linking to the G protein-coupled receptor family. The overlap between Hepsin's enzymatic function and extracellular matrix components highlights its participation in cell proliferation pathways.
Malfunctioning NMDA receptors associate with neurodegenerative diseases like Alzheimer's disease and mood disorders such as depression. Alterations in receptor subunits could lead to abnormal synaptic plasticity. Hepsin's expression has dysregulation ties to certain cancers where its proteolytic activity influences cancer progression. Furthermore aberrations in the TSH receptor associate with thyroid disorders such as Graves' disease affecting hormone regulation and metabolism.
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