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AB270807

NMS-873

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MW 520.7 Da, Purity >98%. Potent and selective VCP ATPase inhibitor (IC50 = 30 nM). Selective against a range of AAA ATPases, HSP90 and kinases (IC50 >10 μM). Activator of unfolded protein response. Modulates maturatiion of autophagosomes. In vitro antiproliferative activity in cancer cell lines. Anti-viral activity towards influenza A and B.
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Chemical Structure - NMS-873 (AB270807)
  • Chemical Structure

Lab

Chemical Structure - NMS-873 (AB270807)

Chemical structure of NMS-873, 1418013-75-8

Key facts

CAS number

1418013-75-8

Purity

>98%

Form

Solid

form

Molecular weight

520.7 Da

Molecular formula

C<sub>2</sub><sub>7</sub>H<sub>2</sub><sub>8</sub>N<sub>4</sub>O<sub>3</sub>S<sub>2</sub>

PubChem

71521142

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

3-(3-(Cyclopentylthio)-5-(((2-methyl-4'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)oxy)methyl)-4h-1,2,4-triazol-4-yl)pyridine

Biological description

Potent and selective VCP ATPase inhibitor (IC50 = 30 nM). Selective against a range of AAA ATPases, HSP90 and kinases (IC50 >10 μM). Activator of unfolded protein response. Modulates maturatiion of autophagosomes. In vitro antiproliferative activity in cancer cell lines. Anti-viral activity towards influenza A and B.

Canonical smiles

CC1=C(C=CC(=C1)OCC2=NN=C(N2C3=CN=CC=C3)SC4CCCC4)C5=CC=C(C=C5)S(=O)(=O)C

InChi

InChI=1S/C27H28N4O3S2/c1-19-16-22(11-14-25(19)20-9-12-24(13-10-20)36(2,32)33)34-18-26-29-30-27(35-23-7-3-4-8-23)31(26)21-6-5-15-28-17-21/h5-6,9-17,23H,3-4,7-8,18H2,1-2H3

InChiKey

UJGTUKMAJVCBIS-UHFFFAOYSA-N

IUPAC Name

3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
-20°C
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Product protocols

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