Skip to main content

MW 520.7 Da, Purity >=98%. Potent and selective VCP ATPase inhibitor (IC50 = 30 nM). Selective against a range of AAA ATPases, HSP90 and kinases (IC50 >10 μM). Activator of unfolded protein response. Modulates maturatiion of autophagosomes. In vitro antiproliferative activity in cancer cell lines. Anti-viral activity towards influenza A and B.

Be the first to review this product! Submit a review

Images

Chemical Structure - NMS-873 (AB270807), expandable thumbnail

Key facts

CAS number
1418013-75-8
Purity
>= 98%
Form
Solid
Molecular weight
520.7 Da
Molecular formula
C27H28N4O3S2
PubChem identifier
71521142
Nature
Synthetic

Target data

Recommended products

MW 520.7 Da, Purity >=98%. Potent and selective VCP ATPase inhibitor (IC50 = 30 nM). Selective against a range of AAA ATPases, HSP90 and kinases (IC50 >10 μM). Activator of unfolded protein response. Modulates maturatiion of autophagosomes. In vitro antiproliferative activity in cancer cell lines. Anti-viral activity towards influenza A and B.

Key facts

Purity
>= 98%
PubChem identifier
71521142
Solubility

Soluble in DMSO to 100 mM.

Biochemical name
3-(3-(Cyclopentylthio)-5-(((2-methyl-4'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)oxy)methyl)-4h-1,2,4-triazol-4-yl)pyridine
Biological description

Potent and selective VCP ATPase inhibitor (IC50 = 30 nM). Selective against a range of AAA ATPases, HSP90 and kinases (IC50 >10 μM). Activator of unfolded protein response. Modulates maturatiion of autophagosomes. In vitro antiproliferative activity in cancer cell lines. Anti-viral activity towards influenza A and B.

Canonical SMILES
CC1=C(C=CC(=C1)OCC2=NN=C(N2C3=CN=CC=C3)SC4CCCC4)C5=CC=C(C=C5)S(=O)(=O)C
InChI
InChI=1S/C27H28N4O3S2/c1-19-16-22(11-14-25(19)20-9-12-24(13-10-20)36(2,32)33)34-18-26-29-30-27(35-23-7-3-4-8-23)31(26)21-6-5-15-28-17-21/h5-6,9-17,23H,3-4,7-8,18H2,1-2H3
InChIKey
UJGTUKMAJVCBIS-UHFFFAOYSA-N
IUPAC name
3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
-20°C

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Chemical Structure - NMS-873 (ab270807), expandable thumbnail

    Chemical Structure - NMS-873 (ab270807)

    Chemical structure of NMS-873, 1418013-75-8

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com